Subarachnoid Haemorrhage as Initial Symptom of Multiple Brain Abscesses

The case of evolving multiple brain abscesses which became symptomatic with a sudden hemianopsia and the clinical and radiological signs of a subarachnoid haemorrhage, is reported. A common pathomechanism which could explain both the sudden focal neurological deficit and the subarachnoid bleeding is discussed.     

Moxifloxacin in experimental Streptococcus pneumoniae cerebritis and meningitis

Rifampin, a protein synthesis inhibitor, reduced mortality in a mouse model of meningitis compared to bacteriolytic cephalosporin standard therapy. To assess whether moxifloxacin (known to cause a less rapid bacteriolysis than cephalosporins) can similarly reduce mortality, mice infected with Streptococcus pneumoniae by deep intracerebral injection were treated subcutaneously with either 200 mg/kg of moxifloxacin or ceftriaxone every 8 hours for 5 days (n=49 each). They were then observed for an additional 8 days. Overall mortalities were 35 and 29 in moxifloxacin- and ceftriaxone-treated mice, respectively (p=0.29). Kaplan-Meier survival analysis also revealed no statistically significant differences (p=0.32). Moxifloxacin failed to reduce mortality compared to cephalosporin standard therapy.     

中西医结合治疗小儿急性病毒性脑炎临床观察

目的 探讨治疗急性病毒性脑炎的有效，安全的治疗方法。方法 采用广羚散，丙种球蛋白联合应用，观察小儿急性病毒性脑炎76例疗程及治疗效果，并与对照组50例比较。结果 治疗组在疗程及疗效方面明显优于对照组（P＜0．01），未见明显副作用。结论：广羚散，丙种球蛋白联合治疗小儿急性病毒性脑炎是一种安全有效疗程短的方法，能否减少后遗症的发生有待进一步观察。     

肺炎支原体脑炎10例临床分析

[目的]探讨小儿肺炎支原体(MP)脑炎的临床特点和诊断方法。[方法]回顾性分析10例支原体脑炎患儿的临床资料。[结果]2例以中枢神经系统症状为首发表现(20%),脑脊液MP-IgM阳性率为40%(4/10),头颅磁共振成像(MRI)阳性率为60%(6/10)。[结论]MP脑炎可直接以中枢神经系统损害起病,脑脊液MP-IgM阳性率低,MRI检查有助于诊断MP脑炎。     

Pathogenesis,clinical course and neuro-radiological signs of Proprionibacterium acnes cerebritis: Case report and literature review

The clinical and neuroimaging characteristics of brain infections related to Propionibacterium acnes are not well-characterized, making early diagnosis and treatment a challenge. More recently, life-threatening central nervous system infections with P. acnes are being reported with increasing frequency as complications of neurointerventional procedures. We present a rare case of P. acnes cerebritis that occurred as a sequela of bare platinum aneurysm coiling and a contaminant of percutaneous angiographic intervention. We include an extensive review of the literature describing the pathogenesis of P. acnes and neuro-radiological signs of brain infections related to this pathogen.     

Interleukin-27 and its relation to disease parameters in SLE patients

IntroductionIL-27 exerts profound anti-inflammatory effects in several experimental autoimmune models, suggesting that it may be therapeutically relevant in SLE.Aim of the workTo evaluate IL-27 level in SLE patients and its association to clinical manifestations, disease activity parameters and management strategy.Patients and methodsWe studied 80 SLE patients and 50 controls in a cross sectional study. Demographic, clinical and serological data were evaluated. Systemic lupus erythematosus disease activity index (SLEDAI) and Systemic Lupus International Collaboration Clinics/ACR damage index (SLICC) were assessed. Serum IL-27 was measured by ELISA.ResultsThere was statistically significant difference in IL-27 level in SLE patients and healthy controls (9.7 ± 21.9 pg/ml vs 20.2 ± 47.3 pg/ml in SLE vs controls, respectively) (p = 0.04), also it was found that IL-27 level was statistically significantly lower in SLE patients with lupus nephritis (p = 0.02) and cerebritis (p = 0.03). Interleukin 27 level had a statistically significant negative correlation with the cumulative dose of hydroxychloroquine and azathioprine (r = ?0.3, p = 0.03 and r = ?0.3 and p = 0.04, respectively).ConclusionIL-27 has anti-inflammatory effect in SLE patients especially those without nephritis or cerebritis and can be therapeutically relevant in SLE. To confirm our results we propose larger scale, multicentre studies with longer evaluation periods.     

流行性脑脊髓膜炎预报的人工神经网络模型

本文支用人工神经网络的一典型模型－“反向传播”模型，以江苏某市１９５０－１９８５年有关气候和流脑发病等级资料为对象，建立了该种流行性疾病预测的计算机智能专家系统。预测效率达１００％，结果表明，该方法性能良好，可望成为流行性疾病预测的有效的手段。     

散发性脑炎的病证属性

根据散脑的临床表现、发病特点,提出散脑虽有昏迷、抽搐,但不当属温病,而应属杂病。对其治疗,提出应重视化湿祛痰法的应用,不应滥用安宫牛黄丸一类寒凉药施治。     

中枢神经系统感染脑脊液肿瘤坏死因子及其意义

探讨化脓性脑膜炎、病毒性脑膜炎或脑炎患儿脑脊液肿瘤坏死因子（TNF）的临床意义。方法采用TNF放免药盒，测定化脑组21例、病毒脑28例、对照组20例的脑脊液TNF。结果化脑组脑脊液TNF阳性率显著高于病毒脑组，化脑组脑脊液肿瘤坏死因子升高的平均浓度显著高于病毒脑组，差异有高度统计学意义。结论对接受过抗生素治疗而诊断不明者，可行脑脊液TNF检测，高水平则提示化脓性脑膜炎。     

Cerebritis: An unusual complication of Klebsiella pneumoniae

Cerebritis is part of a continuum of brain infection and is difficult to diagnose. Cerebritis caused by Klebsiella in immunocompetent adults without predisposing factors such as neurosurgery or penetrating brain injury has not been reported before. We report a case of Klebsiella cerebritis in an adult patient with a proven extracranial focus of infection. We suggest considering cerebritis as a differential diagnosis for altered level of consciousness in patients of severe sepsis, even if an extracranial source of infection is proven.