热应激对人体血浆脂质过氧化和中分子物质浓度的影响

为探索人体热暴露过热时血浆脂质过氧化（ＬＰ）和中分子物质（ＭＭＳ）含量的变化及其相互关系，对１８名健康男子，于早餐后进行热暴露２ｈ导致体温升高，当时平均Ｔｒ：３８．６３±０．２４℃，ＨＲ：１２６．６±１７．１ｂｐｍ，ＳＶ：０．８７３±０．３０７ｋｇ，ＰＳＩ：２．２８８，经汗的失水量占体重的１．３１％，尿ＶＭＡ浓度增高２３．１％，２４ｈ尿ＶＭＡ排出量为４７．６±１０．８μｍｏｌ，超过正常范围。但血浆ＭＭＳ浓度几乎无变化，血浆ＭＤＡ浓度增高６．２％，而血浆ＧＳＨ－ｐｘ浓度增高４６．１％（Ｐ＜０．０１），ＧＳＨ－ｐｘ／ＭＤＡ比值增高３５．８％（Ｐ＜０．０５）。实验显示，早餐后的热暴露未能如晚餐后热暴露明显提高血浆ＭＭＳ浓度和防止过热组织过度的ＬＰ。     

氰戊菊酯对包装工人心血管功能的亚临床影响

目的探讨氰戊菊酯对包装工人心血管功能的亚临床影响。方法对２２名氰戊菊酯包装工和１５名无毒物接触史和无心血管疾病史的工人进行横断面调查，分析其心血管功能的改变。结果包装车间空气中氰戊菊酯时间加权平均浓度（ＴＷＡ）为０．０１７５±０．００５７ｍｇ／ｍ３（ｎ＝４），包装工皮肤平均污染量为０．５１３４±０．４２１６ｍｇ／ｃｍ２（ｎ＝６），工人接触以皮肤污染为主；症状以皮肤粘膜刺激症为主；与对照组比较收缩压升高、心率加快，收缩压与尿中ＶＭＡ明显相关，心电图检查示（Ｑ－Ｔ）ｒ值增大。结论低浓度氰戊菊酯接触对作业工人心血管功能有影响。     

不同民族冷适应水平的研究

冬季在乌鲁木齐市对维族(25名)、藏族(12名)和汉族(43名)战士及21名维族大学生的冷适应水平进行测试。以血浆CPK和FFA、尿中儿茶酚胺和VMA,以及左中指泡冰水20min的皮温作为指标。结果表明藏、维族战士的适应水平优于汉族战士及维族大学生。但进新疆2年以上的汉族战士与藏、维族问无明显差别,加强体力锻炼之后,可使某些生化指标得到改善。作者认为尿中儿茶酚胺和VMA由于测试方法简便,结果稳定,可考虑作为人群冷适应的评价指标。     

锰的接触—反应／效应关系研究

本文对60名接触高浓度和低浓度锰作业工人以及40名非锰作业者(对照组)进行了体格检查,尿锰和尿香草扁桃酸(VMA)测定,发现随着吸入锰烟尘浓度的增高,受检者的神经系统症状和体征以及尿锰和尿VMA 相应增高,经统计学检验有显著性差异。研究结果显示,尿锰和尿VMA 的增高对锰中毒的早期诊断有一定参考价值。     

尿香草扁桃酸测定对锰中毒早期诊断的意义

本文对440名锰作业工人进行了尿香草扁桃酸(VMA)测定,结果明显高于对照纽,差异非常显著(P<0.001)。本文还讨论了锰接触者尿VMA升高的机理。作者认为尿VMA可作为锰中毒早期诊断较为客观的指标。     

Long non-coding RNA LINC00665 promotes melanoma cell growth and migration via regulating the miR-224-5p/VMA21 axis

Melanoma is an aggressive malignant skin tumor endangering the health of patients. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been increasingly reported to be implicated in the carcinogenesis of melanoma. Long intergenic non-coding RNA 00665 (LINC00665) has been found to exert important regulatory roles in some cancers, yet its function in melanoma remains to be investigated. QRT-PCR analysis was conducted to evaluate the relative expression of RNAs. Functional experiments in vitro including colony formation, EdU, wound-healing and transwell assays, as well as in vivo xenograft assays, were utilized to study the role of LINC00665 in melanoma. Mechanical experiments were implemented to probe into the molecular linkage of LINC00665, miR-224-5p and VMA21. LINC00665 was abnormally highly expressed in melanoma cells. Silencing LINC00665 could inhibit the proliferation and migration of melanoma cells. LINC00665 sponged miR-224-5p to upregulate VMA21. VMA21 knockdown exerted similarly interfering effects on above biological processes in melanoma cells. However, VMA21 overexpression abolished the in vitro and in vivo outcomes of LINC00665 silencing. LINC00665 promotes proliferative and migrating abilities of melanoma cells via targeting miR-224-5p/VMA21 axis.     

Neurochemical effect of lead exposure: a study on catecholamine metabolism

In an attempt to examine the neurochemical changes of lead exposure, a study was conducted on 106 lead workers and a control group of 25 nonexposed workers. The urinary excretion of major catecholamine metabolites, homovanillic acid (HVA), and vanillylmandellic acid (VMA) were measured. Workers exposed to lead had a mean blood lead concentration of 43.2 micrograms/100 ml, whereas the concentration for workers not exposed to lead was 12.7 micrograms/100 ml. Urinary HVA was significantly elevated in the exposed group when compared with controls (p less than 0.01). HVA was also found to be associated with an increase of lead in blood. Although not statistically significant, the VMA excretion was also noted to be moderately elevated; however, it is recognized that the present study was unable to establish a highly significant dose-response relationship between lead exposure and HVA excretion, as has been reported earlier in lead-poisoned children.