Sequential treatment by polidocanol and radiofrequency ablation of large benign partially cystic thyroid nodules with solid components: Efficacy and safety

PurposeThe purpose of this study was to retrospectively evaluate the efficacy and safety of a sequential treatment including percutaneous polidocanol sclerotherapy and radiofrequency ablation (RFA) in terms of volume reduction and complication rate in large, benign, partially cystic thyroid nodules with solid components.Materials and methodFrom April 2017 to April 2019, 46 patients with 47 large benign partially cystic thyroid nodules underwent sequential treatment. There were 14 men and 32 women with a mean age of 49.9 ± 11.5 (SD) years (range: 18–75 years). The volume of initial nodules was 12.7 ± 12.3 (SD) mL (range: 2.16–75.62 mL). Volume reduction after percutaneous polidocanol sclerotherapy and further RFA was evaluated respectively. Patients had clinical and ultrasound evaluations at a follow-up time of 12.1 ± 5.3 (SD) months (range: 1.5–23.9 months). Technical success and complications were accessed retrospectively.ResultsAfter unsatisfying results with polidocanol sclerotherapy alone the 46 patients with 47 large benign partially cystic thyroid nodules had further RFA. Mean volume reduction of 47 nodules was 90.5 ± 11.3 (SD) % (range: 43.9–99.3%) one month after RFA, 94.9 ± 6.2 (SD) % (range: 66.9–99.5%) three months after RFA, and 95.8 ± 5.5 (SD) % (range: 71.0–99.8%) six months after RFA. No recurrence or nodule enlargement after RFA was observed at the last follow-up. The complication rate of RFA was 12.5% (8/46 patients), with minor complications only.ConclusionsThe sequential treatment regimen, including percutaneous polidocanol sclerotherapy and RFA, is an appropriate and safe treatment strategy for large benign partially cystic thyroid nodules with solid components.     

聚多卡醇治疗红斑毛细血管扩张型玫瑰痤疮12例疗效观察

目的探讨聚多卡醇治疗红斑毛细血管扩张型玫瑰痤疮的临床疗效和安全性。方法采用局部注射聚多卡醇治疗12例红斑毛细血管扩张型玫瑰痤疮患者,并观察临床疗效。结果 12例患者均达痊愈标准,治疗后局部无再出血、渗出、破溃、色素沉着及瘢痕。随访6个月,未见复发。结论聚多卡醇局部注射治疗红斑毛细血管扩张型玫瑰痤疮疗效显著,美容效果好,具有很好的临床应用前景。     

Sclerosing injections to treat midportion Achilles tendinosis: a randomised controlled study evaluating two different concentrations of Polidocanol

Two to three ultrasound (US) and colour Doppler (CD)-guided injections of the sclerosing substance Polidocanol (5 mg/ml) have been demonstrated to give good clinical results in patients with chronic midportion Achilles tendinopathy. This study aimed to investigate if a higher concentration of Polidocanol (10 mg/ml) would lead to a less number of treatments, and lower volumes, needed for good clinical results. Fifty-two consecutive Achilles tendons (48 patients, mean age 49.6 years) with chronic painful midportion Achilles tendinopathy, were randomised to treatment with Polidocanol 5 mg/ml (group A) or 10 mg/ml (group B). The patients and treating physician were blinded to the concentration of Polidocanol injected. All patients had structural tendon changes and neovascularisation in the Achilles midportion. Treatment was US + CD-guided injections targeting the region with neovascularisation (outside ventral tendon). A maximum of three treatments (6-8 weeks in between) were given before evaluation. Patients not satisfied after three treatments were given additional treatment with Polidocanol 10 mg/ml, up to five treatments. For evaluation, the patients recorded the severity of Achilles tendon pain during activity on a visual analogue scale (VAS), before and after treatment. Patient satisfaction with treatment was also assessed. At follow-up (mean 14 months) after three treatments, 18/26 patients in group A and 19/26 patients in group B were satisfied with the treatment and had a significantly reduced level of tendon pain (P < 0.05). After completion of the study, additional treatments with Polidocanol 10 mg/ml in the not satisfied patients resulted in 26/26 satisfied patients in both groups A and B. In summary, we found no significant differences in the number of satisfied patients, number of injections or volumes given, between patients treated with 5 or 10 mg/ml Polidocanol.     

Sclerotherapy for hydrocele revisited: a prospective randomised study

Purpose  

A prospective randomised trial to study the efficacy and safety of hydrocele sclerotherapy with phenol and polidocanol.     

聚桂醇硬化剂治疗口腔颌面部血管瘤和脉管畸形专家共识

[提要] 血管瘤和脉管畸形是一组复杂的来源于脉管系统的疾病。婴幼儿血管瘤以内皮细胞增殖为特征,是最常见的婴幼儿良性肿瘤。脉管畸形是胚胎发育时期脉管系统发育异常所致,超过60%的脉管畸形发生于头颈部。血管瘤和脉管畸形可能引起严重的面部畸形和功能障碍,硬化治疗是其常用的治疗方法。过去常用的硬化剂有平阳霉素、博来霉素、无水乙醇、十四烷基硫酸钠、OK-432、强力霉素、鱼肝油酸钠等。近年来,国产硬化剂聚桂醇被广泛用于血管瘤和脉管畸形的治疗,泡沫化硬化治疗技术的发展推动了其临床应用,其治疗有效性和安全性已被大量研究所证实。为了进一步规范该技术的应用,我们组织专家制定了该专家共识。今后将依据最新出版的文献和临床治疗经验及时更新,为该领域的临床医师提供指导。     

The efficacy of sclerosing injections in the treatment of painful tendinopathy

Abstract

Background: Based on the assumption that neovascularization is a cause of tendon pain, sclerosing injections have increasingly been used to treat chronic tendon conditions. A number of clinical studies have investigated the efficacy of this intervention.

Objective: The aim of this study was to review the literature relating to the use of sclerosing injections for the management of painful tendinopathy.

Method: Medline, CINAHL, PEDro, Cochrane Database, PubMed, EMBASE, AMED, Scopus, and Web of Science were searched. Of 4632 abstracts identified, 24 were retained for further analysis. Each abstract was assessed by three reviewers; nine studies (four randomized controlled trials, four pilot studies, and one comparative study) met our inclusion criteria. Quality was assessed using the Downs and Black Scale.

Results: Two outcome measures were utilized: visual analogue score (VAS) for pain and estimated assessment of neovascularization. Seven trials reported some improvement in pain. Results from the three highest quality trials were inconclusive. Five trials reported a change in neovascularization pre- and post-intervention. One trial additionally used the Victoria Institute of Sports Assessment (VISA) to record pain outcomes.

Conclusions: The clinical significance of neovascularization as a cause of pain is contentious. Currently, there is insufficient robust evidence to support the use of sclerosing injections in the treatment of painful tendinopathy with concomitant neovascularity. Further clinical, imaging and laboratory studies investigating the relationship between neovascularity, tendon pain and its management are required.     

Polidocanol sclerotherapy for multiple gastrointestinal hemangiomas: A case report

BACKGROUNDGastrointestinal (GI) hemangioma has a low incidence among systemic hemangiomas, and some GI hemangiomas occur in the intestine, stomach, and esophagus. Polidocanol has been increasingly used in sclerotherapy. However, this paper reports that minimally invasive treatment of multiple hemangiomas with large diameters can achieve satisfactory results by multipoint injection.CASE SUMMARYA 46-year-old female patient was hospitalized in another hospital for cough. We accidentally found thickening of the lower esophagus by chest computed tomography. The patient was eventually diagnosed with multiple GI hemangiomas and underwent a series of examinations including esophagogastroduodenoscopy (EGD), endoscopic ultrasound, and magnetic resonance imaging. We calculated the dose of polidocanol according to the volumes of the hemangiomas, fixed the target vein with the help of a transparent cap, and then administered polidocanol via multipoint injection into the hemangiomas under endoscopic guidance. EGD and endoscopic ultrasound showed that the hemangiomas disappeared. The color of the esophageal mucosa returned to normal 1 mo after sclerotherapy.CONCLUSIONSclerotherapy may be a safe and effective method for treating multiple hemangiomas of the alimentary canal.     

聚多卡醇联合弹簧圈栓塞治疗精索静脉曲张的临床疗效

目的 分析聚多卡醇联合弹簧圈栓塞治疗精索静脉曲张的临床疗效.方法 对2017年2月至2020年2月潍坊医学院附属医院收治的28例精索静脉曲张患者进行经聚多卡醇联合弹簧圈栓塞治疗,观察患者术前及术后静脉反流、精液改善质量情况并随访12个月,评估栓塞治疗效果.结果 28例精索静脉曲张患者均接受栓塞治疗.术后经精索静脉超声检...     

DSA引导下泡沫硬化术与大隐静脉高位结扎联合血管腔内激光术治疗下肢静脉曲张的疗效观察

目的探讨DSA引导下聚多卡醇泡沫硬化术与大隐静脉高位结扎术联合血管腔内激光术治疗下肢静脉曲张的临床疗效。 方法选取60例下肢静脉曲张患者（共66条腿）,随机分为DSA引导下聚多卡醇泡沫硬化术组（A组,30例共33条腿）及大隐静脉高位结扎术联合血管腔内激光术组（B组,30例共33条腿）。分别对两组患者手术时间、住院费用、术后并发症、治疗效果进行对比评价。 结果A组患者手术时间、住院费用明显低于B组（均P<0.01）;A组患者术后皮下瘀血、感觉麻木、皮下脂肪液化感染、皮肤灼伤的发生率均显著低于B组（均P<0.01）;两组患者静脉炎的发生率差异无统计学意义（P>0.05）;两组患者出院时及术后3个月、6个月、1年治疗效果比较差异均无统计学意义（均P>0.05）。 结论DSA引导下聚多卡醇泡沫硬化剂治疗下肢静脉曲张是一项创伤小、并发症少、安全、有效的治疗方法。