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1.
《Vaccine》2022,40(42):6048-6054
BackgroundLive vaccines potentially have non-specific effects that protect against other infections than those the vaccines are targeted against. The national vaccination program (NVP) in Finland was changed on September 1st, 2006: before BCG vaccine was given to all newborn babies and afterwards to babies in risk groups only. We used this natural experiment to study the non-specific effects of BCG in the frame of NVP using before-after design.MethodsWe compared the incidence of several outcomes obtained from Finnish health registers between children born between July 1st, 2004, and June 30th, 2006 (BCG-eligible) and an age- and season-matched reference cohort born between July 1st, 2007, and June 30th, 2009 (BCG-non-eligible) using Poisson regression. These cohorts were restricted to full-term children whose parents were born in Finland. Follow-up began at birth and lasted 3 months, which is the scheduled age for DTaP-IPV-Hib vaccination, and from 4 months until first birthday. The outcomes included all infections, pneumonia and injuries as a negative control outcome.ResultsThe incidence rate ratio (IRR) of the BCG-eligible cohort (N = 93,658) compared to BCG-non-eligible cohort (N = 94,712) for hospital-diagnosed infections was 0.89 (95 %Cl 0.86–0.93) for the 3-month follow-up. The decrease was mainly caused by respiratory infections. In 4–12 months follow-up the BCG-eligible had slightly more infections than BCG-non-eligible children (IRR 1.03, 1.01–1.06).ConclusionsBCG vaccination was associated with a lower incidence of all hospital-diagnosed infections during the first three months of life. The difference cannot be attributed to lung tuberculosis, since only few paediatric cases occurred in Finland during 2000s. The disappearance of non-specific effect after administration of an inactivated vaccine is compatible with previous studies. 相似文献
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The treatment of neoplasia with interleukin-2 (IL-2) can be complicated by neurological deficits resembling transient Ischemic attack and stroke. We investigated whether interleukin-2 contributes to the natural course of cerebrovascular ischemia and particularly to the pathogenesis of infection-associated stroke. Plasma levels of interleukin-2 were below the level of detectability in almost all measurements. Patients with and without previous infection (n = 11, 805 ±445 U/ml vs n = 19, 824 ± 501 U/ml) did not have significantly higher levels of soluble interleukin-2 receptors than control subjects with (n = 14, 667 ± 229 U/ml) or without vascular risk factors (n = 17, 567 ± 176 U/ml). Receptor levels increased in patients during the first week after stroke (n = 15, 1157 ± 1013, p < 0.02). Levels of soluble T8 antigen (sT8) were higher in patients (n – 26, 320 ± 112 U/ml) than in healthy control subjects (n = 15, 246 ± 92 U/ml; p < 0.05) and sT8 levels increased during the first week after stroke (p < 0.05). These results reflect an immunological response to the cerebral infarct; they do not indicate a general role of the IL-2 system in the pathogenesis of ischemic stroke with or without previous infection. 相似文献
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One hundred and one patients, nursed in an intensive care unit for at least 24h, were monitored for bacterial colonization
and infection. The infection rates were similar to those in other reports. Patients were not generally colonized with common
environmental strains in the unit. Bacterial dissemination between patients was uncommon. No gentamicin resistant gram negative
or Staphylococcus aureus strains were observed, nor methicillin resistant Staphylococcus aureus strains. the hypothesis that these favourable conditions are partly related to the excellent isolation and barrier nursing
facilities in the unit cannot be fully substantiated. 相似文献
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We evaluated retrospectively the varying radiographic appearances of 15 solitary lucent epiphyseal lesions occurring in children. Imaging modalities used included plain films, conventional tomography, nuclear scintigraphy, and computed tomography. Forty percent of the lesions (6) were due to osteomyelitis. The remaining lesions included tuberculosis (1), foreign body granuloma (1), chondroblastoma (2), chondromyxoid fibroma (1), enchondroma (1), osteoid osteoma (2), and eosinophilic granuloma (1). Although the radiographic appearances of such lesions may be particularly characteristic, pathologic correlation is frequently necessary. The high incidence of osteomyelitis in our cases emphasizes its importance as a cause for a lucent epiphyseal lesion. 相似文献
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Dr. A. J. G. Swaak R. M. Van Soesbergen J. K. Van Der Korst 《Clinical rheumatology》1982,1(4):275-279
Summary Six cases of arthritis caused by or associated with Salmonella infection are reported. It is stated that an arthritis associated with a Salmonella infection cannot be excluded on the negative results of the Widaltest. Consequent upon Salmonella infection two different types of arthritis might develop: a) monoarticular infectious arthritis or b) a subacute reactive oligo-articular arthritis. In this study a patient with a chronic destructive reactive oligoarthritis is described, resembling experimental Salmonella-associated arthritis in rats. This form of arthritis might be regarded as an immune complex mediated disease associated with a chronic infection. 相似文献
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国产与进口盐酸头孢吡肟治疗下呼吸道、泌尿道感染多中心临床试验 总被引:1,自引:0,他引:1
目的评价国产盐酸头孢吡肟和进口盐酸头孢吡肟治疗下呼吸道、泌尿道细菌染性疾病的疗效和安全性。方法前瞻性、多中心、随机、双盲、阳性药平行对照研究,共入组131例,其中国产盐酸头孢吡肟组66例,进口盐酸头孢吡肟组65例。两药剂量均为每日2.0g,q12h,静滴,疗程7~14d。结果国产和进口盐酸头孢吡肟治疗下呼吸道感染的临床痊愈率分别为53.1%和41.9%,有效率分别为90.6%和80.7%;治疗泌尿系感染痊愈率分别为85.3%和81.8%,有效率分别为94.1%和100.0%,细菌清除率国产盐酸头孢吡肟组91.8%;进口盐酸头孢吡肟组100.0%。国产和进口盐酸头孢吡肟组不良反应发生率分别为3.0%和6.2%。两组疗效和不良反应无统计学差异(P>0.05)。结论国产盐酸头孢吡肟治疗下呼吸道感染、泌尿道感染性疾病安全、有效,与进口头孢吡肟疗效相当。 相似文献