全文获取类型
收费全文 | 1457篇 |
免费 | 124篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 34篇 |
妇产科学 | 1篇 |
基础医学 | 374篇 |
口腔科学 | 1篇 |
临床医学 | 103篇 |
内科学 | 180篇 |
皮肤病学 | 52篇 |
神经病学 | 8篇 |
特种医学 | 15篇 |
外科学 | 73篇 |
综合类 | 94篇 |
预防医学 | 78篇 |
眼科学 | 59篇 |
药学 | 220篇 |
中国医学 | 60篇 |
肿瘤学 | 236篇 |
出版年
2024年 | 4篇 |
2023年 | 15篇 |
2022年 | 62篇 |
2021年 | 60篇 |
2020年 | 39篇 |
2019年 | 43篇 |
2018年 | 34篇 |
2017年 | 49篇 |
2016年 | 57篇 |
2015年 | 57篇 |
2014年 | 57篇 |
2013年 | 120篇 |
2012年 | 72篇 |
2011年 | 90篇 |
2010年 | 65篇 |
2009年 | 61篇 |
2008年 | 75篇 |
2007年 | 58篇 |
2006年 | 54篇 |
2005年 | 40篇 |
2004年 | 50篇 |
2003年 | 35篇 |
2002年 | 34篇 |
2001年 | 25篇 |
2000年 | 37篇 |
1999年 | 28篇 |
1998年 | 19篇 |
1997年 | 29篇 |
1996年 | 36篇 |
1995年 | 12篇 |
1994年 | 18篇 |
1993年 | 16篇 |
1992年 | 15篇 |
1991年 | 15篇 |
1990年 | 16篇 |
1989年 | 19篇 |
1988年 | 17篇 |
1987年 | 15篇 |
1986年 | 12篇 |
1985年 | 8篇 |
1984年 | 7篇 |
1983年 | 5篇 |
1982年 | 9篇 |
1981年 | 8篇 |
1980年 | 6篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1976年 | 4篇 |
排序方式: 共有1613条查询结果,搜索用时 15 毫秒
1.
Davies S. P.; Webb W. J. S.; Patou G.; Murray W. K.; Denning D. W. 《Nephrology, dialysis, transplantation》1987,2(6):568-572
The second documented case of renal aspergilloma due to Aspergillusflavus is presented. The merits of the medical therapy thatfailed are discussed. Pathological examination showed a nidusof aspergillus around suture material persisting from a pyelolithotomyoperation 2 years before in India. We argue that this was thereason for the failure of the medical therapy. This is the firstcase of its kind reported. 相似文献
2.
Vandana Jain Supriya Dabir Debraj Shome Tina Dadu Sundaram Natarajan 《Survey of ophthalmology》2009,54(2):286
We report the case of a 25-year-old male patient who presented with complaints of redness, photophobia, and decreased vision in the right eye of a week's duration. Slit-lamp biomicroscopic examination revealed a cream-colored, irregular elevated inferior iris mass, extending on to the anterior lens surface. Differential diagnoses of a fungal granuloma, a medulloepithelioma, and an amelanotic melanoma were considered. An excisional biopsy of the mass was performed through a superior clear corneal incision. Polymerase chain reaction analysis of the aqueous humor showed a positive pan fungal genome. Histopathology of the biopsied mass showed a giant cell granuloma with surrounding numerous branching, septate hyphae. Culture growth revealed Aspergillus fumigatus We report this case because of the rarity of Aspergillus iris granuloma as a primary presentation of endogenous Aspergillosis and review the relevant literature. Absence of a significant systemic history compounded the diagnostic dilemma in our patient. Definitive differentiation of this rare entity from a foreign body, amelanotic melanoma, and other inflammatory conditions such as sarcoidosis and tuberculosis, may be possible only on microbiological and histo-pathological evaluation. 相似文献
3.
4.
1976~1991年我院收治慢性重症病毒性肝炎并发曲霉菌感染15例,感染于住院后3~112天,<30天9例。以血性痰液、胸水、腹水、脑脊液为特点。多数周围血象白细胞不增高,中性粒细胞增高,IgG增高,曲霉菌( );感染后2~10天均死亡。感染前咽部检出白色念珠菌6例,滥用抗生素者占80%。 相似文献
5.
A strain of Aspergillus fumigatus has been isolated from sediments of a mussel bed. When cultured in hyper saline conditions (with sea-water), it produces a cytotoxic and immunosuppressive toxin, gliotoxin, which is excreted in an exudate. In order to know if this toxin could represent a risk for shellfish consumers, an experiment of bioaccumulation of gliotoxin in mussel has been carried out. After 6 days of contamination, toxin was accumulated in the meat of the mussels, at a level up to 2.9 microg/mg of extract weight, with a mode of contamination different to the classical digestive process described for a majority of marine toxins, but similar to the contamination mode of domoic acid. 相似文献
6.
Aspergillus osteomyelitis is a rare condition and is a recognized infection of the immunosuppressed. The pediatric cases that were documented suggest that in children, chronic granulomatous disease is the major underlying disease [Tack et al.1982 73(2):295–300, Baez-Escudero et al. 2000 Case report—primary sternal Aspergillus osteomyelitis. Infect Med 17(7):505–516]. We report an interesting case of Aspergillus osteomyelitis of the thumb in a 5-year-old boy with aplastic anemia. The infection progressed despite a combination of antifungal therapy with Voriconazole and surgical debridement. The thumb was amputated and the child recovered. This case highlights the difficulty in diagnosing Aspergillus osteomyelitis and also the failure of conventional management in this child, which resulted in the amputation of the thumb as a life-saving measure. We believe this to be the first case report of Aspergillus osteomyelitis in the thumb. 相似文献
7.
The susceptibilities of 40 clinical isolates of Aspergillus spp. (Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Aspergillus terreus) were determined for posaconazole and voriconazole by the CLSI M38-A and EUCAST-AFST broth dilution methods. Where a discrepancy was observed between the methods, the EUCAST method tended to give higher MIC values. Overall, the level of agreement was 92.5% and the intra-class correlation coefficient was > 0.90. 相似文献
8.
Hiroyoshi Tsubochi Shunsuke Endo Kohzo Suhara Yasunori Sohara 《European journal of cardio-thoracic surgery》2007,31(6):1144-1146
Endobronchial aspergillosis or actinomycosis associated with broncholithiasis is extremely rare. Here, we describe two cases of endobronchial aspergillosis and actinomycosis associated with broncholithiasis. The patients underwent pulmonary resection due to massive hemoptysis. These cases reveal that a bronchiolith can potentially induce endobronchial fungal or bacterial infection, even in immunocompetent patients. 相似文献
9.
The sD gene of Aspergillus nidulans has been cloned by heterologous screening of rationally selected cosmids. Co-transformation of the sD50 mutant JMP1 confirmed the presence of a functional gene. Sequence analysis determined this gene to be 680 bp in length, containing
a 59-bp intron and encoding a protein of 206 amino acids. A protein-sequence comparison revealed a similarity to the C-terminal
region of ATP sulphurylase, the sC gene product. Further sequence comparison revealed differences in a consensus sequence ATP-binding motif, indicating non-functionality
of the APS kinase-like domain of ATP sulphurylase, and confirms sD as the gene encoding APS kinase in A. nidulans.
Received: 17 April / 29 August 1997 相似文献
10.
Tanis B. C.; Verburgh C. A.; Van't Wout J. W.; Van Der Pijl J. W. 《Nephrology, dialysis, transplantation》1995,10(7):1240-1243
Aspergillus peritonitis is a rare complication of continuousambulatory peritoneal dialysis. The case is described of a 68-year-oldman in whom Aspergillus fumigatus was isolated from the peritonealdialysate after recurrent peritonitis with Gram-negative rodsin association with diverticulosis. Treatment consisting ofremoval of the catheter and intravenous administration of amphotericinB followed by oral itraconazole was successful. A review of the sparse literature (12 cases) displays uncertaintiesregarding diagnostic awareness, culture diagnosis, and therapeuticmanagement. Next to institution of appropriate antifungal therapy,early removal the peritoneal dialysis catheter is recommended,as delayed removal of the catheter appears to be associatedwith increased mortality and morbidity. 相似文献