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1.
目的 粒细胞缺乏性小肠结肠炎在临床上以粒细胞缺乏、腹痛和高热为三大主症.本文回顾了粒细胞缺乏性小肠结肠炎患儿17例,对其临床特征、治疗和预后进行分析.方法 总结复旦大学附属儿科医院2004至2009年5年间粒细胞缺乏性盲肠炎息儿的临床资料,并进行文献复习.结果 17例患儿,男11例,女6例,平均年龄7.2岁.2例淋巴瘤,11例白血病,1例再生障碍性贫血,1例神经母细胞瘤,2例单纯性粒细胞缺乏而无明显的基础性疾病证据.所有患儿均有典型的临床表现,4例有弥漫性腹膜炎,中毒性休克,其中3例需要呼吸机辅助通气治疗.体检发现有右下腹压痛和肌紧张.伴有CRP的升高和电解质的紊乱.血培养阳性率47%.CT、B超提示肠壁增厚,盲肠或右侧结肠充气减少,气腹等.13例患儿接受内科保守治疗,4例手术干预.2例死亡.结论 粒细胞缺乏性小肠结肠炎是由粒细胞缺乏所引起的危及生命的消化道并发症,临床及CT表现可明确诊断.早期发现和积极的内科治疗可减少病死率.大多数的患儿可通过保守治疗,避免外科手术而获得良好的预后.Abstract: Objective To summarize our experience with disgnosis and treatment of neutropenic enterocolitis in children. Methods From 2004 to 2009, 17 patients were diagnosed with neutropenic enterocolitis, and treated at this center. Their clinical data were retrospectively analyzed to summarize the clinical features, managment experience and evaluate the outcome of neutropenic enterocolitis. Results Among the 17 patients, 11 were males and 6 were females. Their avergae age at diagnosis was 7. 2 years old. The primary diseases that caused neutropenia in these patients were lyphoma in 2 patients, leukemia in 11 patients,aplastic anemia in 1, neuroblastoma in 1, and primary neutropenia in 2. All the patients presented enterocolitis symptoms like fever, vomitting, and diarrhea. Physical examination found lower right abdominal pain and abdominal rigidity. C-reactive protein (CRP) and electrolyte disorder were also noted in these patients. The postive culture rate of blood bacterial was 47%.Computered tomography and ultrasonography revealed intestinal wall thickening, decreased air content in cecum and right colon, and peumoperitoneum. Four patients had diffused peritonitis and sepsis shock. Three of them need mechical ventilation. Among the 17 patients, 4 had surgery. Two patients died. Conclusions Neutropenic enterocolitis is a life-threatening gastrointestinal complication of neutropenia. Early diagnosis and intervention can reduce mortality and improve the prognose of these patients. 相似文献
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Anthony F. Massoll Stanlyn C. Powers David P. Betten 《The American journal of emergency medicine》2017,35(5):803.e5-803.e6
Infectious mononucleosis secondary to Epstein-Barr virus typically follows a relatively benign and self-limited course. A small subset of individuals may develop further progression of disease including hematologic, neurologic, and cardiac abnormalities. A mild transient neutropenia occurring during the first weeks of acute infection is a common finding however in rare cases a more profound neutropenia and agranulocytosis may occur up to 6 weeks following the onset of initial symptoms. We describe the case of an 18-year-old woman who presented 26 days following an acute infectious mononucleosis diagnosis with agranulocytosis and fever. No source of infection was identified and the patient had rapid improvement in her symptoms and resolution of her neutropenia. The presence of fever recurrence and other non-specific symptoms in individuals 2–6 weeks following acute infectious mononucleosis symptom onset may warrant further assessment for this uncommon event. 相似文献
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Istomin V Sade E Grossman Z Rudich H Sofer O Hassin D 《European Journal of Internal Medicine》2004,15(8):531-533
In the course of 6 years, 23 otherwise healthy patients with acute febrile illness and leukopenia were diagnosed as having acute parvovirus B19 infection. Five of these patients had agranulocytosis associated with acute parvovirus B19 infection and one had chronic agranulocytosis due to persistent parvovirus B19 infection. The diagnosis was made after positive anti-parvovirus B19 IgM antibodies were found in all of the patients and viral DNA was detected by PCR in four patients. Neutropenia and agranulocytosis appear to be much more frequently associated with parvovirus B19 infection than previously reported. 相似文献
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摘 要1例30岁男性患者因皮肤软组织感染,给予头孢他啶2 g,ivd,bid,用药21 d后出现发热、咽痛症状,血常规示白细胞计数(WBC)1.3×109·L-1、中性粒细胞绝对数(NEUT)0.4×109·L-1,管床医师要求临床药师介入,临床药师建议停用头孢他啶,给予地榆升白片0.2 g,po,tid。停药第2 d复查血常规:WBC 2.5×109·L-1、NEUT 0.28×109·L-1,给予万古霉素0.5 g,ivd,q8h、重组人粒细胞刺激因子注射液300 μg,ih,qd。停药第3日,患者体温恢复正常,WBC 8.9×109·L-1、NEUT 5.71×109·L-1。患者出院后1年内随访血常规均正常。 相似文献
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1 例62 岁结肠癌男性患者,接受伊立替康80 mg 静脉滴注d1、d8 化疗.化疗后反复腹泻11 d,化疗第13 天腹泻加重伴发热,急诊入院.查血常规示WBC 0.34×109·L-1,NEUT 5.94%,L 85.34%,RBC 3.84×1012·L-1,Hb 114.0 g·L-1,PLT 33×109·L-1.BUN 13.71 mmol·L-1,Scr 291 μmol·L-1.给予头孢匹罗抗感染,重组人粒细胞集落刺激因子升白细胞,免疫调节,止泻、护肾、补液等对症治疗,入院第2 天出现感染性休克,给予抗休克等治疗.第3 天出现深度昏迷,血压难以维持.最终因循环、呼吸衰竭死亡. 相似文献
7.
Cihan A Menteş BB Sucak G Karamercan A Naznedar R Ferahköşe Z 《Diseases of the colon and rectum》1999,42(12):1644-1648
An unusual case of Fournier's gangrene after hemorrhoidectomy and drug-induced agranulocytosis, as the predisposing condition, is described. The patient had severe granulocytopenia that was attributed to the recent use of dipyrone. Together with hemodynamic resuscitation, broad-spectrum antibiotic and recombinant human granulocyte colony-stimulating factor were started. Wide surgical excision of all the gangrenous tissues, in addition to laparoscopic formation of a defunctioning sigmoid loop colostomy, was performed. The white blood cell count rose steadily and the patient experienced a rapid recovery. We emphasize that radical surgery must be accompanied by pharmacologic interventions for a successful outcome in such cases. 相似文献
8.
Agranulocytosis following infectious mononucleosis 总被引:1,自引:0,他引:1
S. Sumimoto Y. Kasajima T. Hamamoto T. Miyanomae Y. Iwai M. Mayumi H. Mikawa 《European journal of pediatrics》1990,149(10):691-694
A girl developed acute agranulocytosis (45/mm3), 37 days after the onset of infectious mononucleosis. The bone marrow showed myeloid hyperplasia with maturation arrest and erythroid hypoplasia. A normal amount of colony forming units of granulocytes and macrophages (CFU-GM) colonies with a relative high number of clusters was observed. Neither anti-neutrophil antibodies nor circulating inhibitors of colony growth were found in serum. Granulocyte and macrophage colony stimulating factor (GM-CSF) activity in the patient's serum rose at this time. The agranulocytosis lasted 5 days and her clinical state soon improved. These results suggested that agranulocytosis was presumably not due to serum factors, including auto-antibodies and/or suppressive substances, and that Epstein-Barr virus (EBV) had some direct or indirect effect on the marrow cells of the myeloid series. 相似文献
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Horwitz M Li FQ Albani D Duan Z Person RE Meade-White K Benson KF 《Cancer investigation》2003,21(4):579-587
Severe congenital neutropenia (SCN), a heterogeneous disorder that includes Kostmann syndrome, predisposes to myelodysplasia and acute myelogenous leukemia. Recently identified heterozygous mutations in the gene ELA2, encoding neutrophil elastase on human chromosome 19pter, account for the majority of autosomal dominant cases of SCN, including those demonstrating neoplastic progression. The involvement of the serine protease neutrophil elastase, localized to the granules of neutrophils and monocytes, implies an unexpected role for proteolytic regulation of hematopoiesis. Continued elucidation of the clinical features, molecular genetics, and biochemistry is likely to provide insight into novel pathways of leukemia induction with attendant prospects for new avenues of therapy. 相似文献