全文获取类型
收费全文 | 5988篇 |
免费 | 371篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 102篇 |
妇产科学 | 136篇 |
基础医学 | 942篇 |
口腔科学 | 292篇 |
临床医学 | 444篇 |
内科学 | 1435篇 |
皮肤病学 | 177篇 |
神经病学 | 435篇 |
特种医学 | 208篇 |
外科学 | 783篇 |
综合类 | 54篇 |
预防医学 | 287篇 |
眼科学 | 66篇 |
药学 | 421篇 |
中国医学 | 12篇 |
肿瘤学 | 550篇 |
出版年
2023年 | 37篇 |
2022年 | 59篇 |
2021年 | 148篇 |
2020年 | 72篇 |
2019年 | 107篇 |
2018年 | 120篇 |
2017年 | 98篇 |
2016年 | 125篇 |
2015年 | 120篇 |
2014年 | 152篇 |
2013年 | 214篇 |
2012年 | 374篇 |
2011年 | 336篇 |
2010年 | 174篇 |
2009年 | 176篇 |
2008年 | 335篇 |
2007年 | 344篇 |
2006年 | 325篇 |
2005年 | 335篇 |
2004年 | 289篇 |
2003年 | 276篇 |
2002年 | 281篇 |
2001年 | 162篇 |
2000年 | 141篇 |
1999年 | 154篇 |
1998年 | 69篇 |
1997年 | 37篇 |
1996年 | 37篇 |
1995年 | 26篇 |
1994年 | 34篇 |
1993年 | 32篇 |
1992年 | 84篇 |
1991年 | 92篇 |
1990年 | 87篇 |
1989年 | 111篇 |
1988年 | 100篇 |
1987年 | 87篇 |
1986年 | 84篇 |
1985年 | 67篇 |
1984年 | 33篇 |
1983年 | 45篇 |
1981年 | 28篇 |
1980年 | 22篇 |
1979年 | 55篇 |
1978年 | 23篇 |
1977年 | 25篇 |
1972年 | 20篇 |
1969年 | 25篇 |
1968年 | 32篇 |
1966年 | 25篇 |
排序方式: 共有6384条查询结果,搜索用时 15 毫秒
1.
2.
3.
Concurrent presence of metabolic syndrome in obstructive sleep apnea syndrome exacerbates the cardiovascular risk: a sleep clinic cohort study. 总被引:2,自引:0,他引:2
Kazuki Shiina Hirofumi Tomiyama Yoshifumi Takata Yasuhiro Usui Kihiro Asano Yoji Hirayama Takeshi Nakamura Akira Yamashina 《Hypertension research》2006,29(6):433-441
This cross-sectional study was conducted to examine whether the obstructive sleep apnea syndrome (OSAS) is associated with elevation of the pulse wave velocity (PWV) and increase in the plasma levels of C-reactive protein (CRP), both of which are known markers of cardiovascular risk, and also to determine if the concurrent presence of the metabolic syndrome might exacerbate this elevation in the levels of these cardiovascular risk markers in subjects with OSAS. With these objectives, the PWV and serum CRP were measured in 184 subjects attending a sleep clinic. It was found that the PWV and CRP were higher in the subjects with OSAS (n=94) than in those without OSAS (n=90). Furthermore, among the subjects with OSAS, the PWV and CRP were higher in those with the concurrent presence of the metabolic syndrome (n= 41; PWV=1,562+/-19 cm/s; CRP=1.8+/-0.2 mg/l) than in those without metabolic syndrome (n=53; PWV=1,432+/-21 cm/s; CRP=1.2+/-0.1 mg/l) (p<0.05). A general linear model analysis demonstrated that OSAS and metabolic syndrome were independently associated with elevated PWV and increase of the plasma levels of CRP. OSAS appears to be associated with increased cardiovascular risk, as reflected by both elevated PWV and increase of the plasma CRP. The concurrent presence of metabolic syndrome may exacerbate this increase in cardiovascular risk in subjects with OSAS. Therefore, the concurrent presence of metabolic syndrome may constitute an additive cardiovascular risk factor in subjects with OSAS. 相似文献
4.
Spinal antinociceptive effects of adenosine compounds in mice 总被引:1,自引:0,他引:1
The effects of injecting ATP, ADP, AMP, adenosine and adenine intrathecally on the pain response induced by the injection of substance P (10 ng/mouse) intrathecally were studied. All the compounds except adenine inhibited the pain response in a dose-related manner. The ED50 values of ATP, ADP, AMP and adenosine were 2.10, 0.93, 0.88 and 0.48 micrograms/mouse, respectively. Pretreatment with theophylline at a dose of 100 mg/kg p.o. markedly diminished all the antinociceptive effects. The effect of adenosine was not affected by s.c. injection of naloxone. These results suggest the existence of adenosine receptors which modulate spinal nociceptive sensory processing, independently of the endogenous opiate system. 相似文献
5.
6.
Tetsushi Tsujimoto Kazushi Daimon Kazuhide Izumi Maki Sawai Tatsuya Iwashige 《Seishin shinkeigaku zasshi》2007,109(4):313-320
Fifty two outpatients, who showed signs of school-refusal-withdrawal at the Shiga Prefectural Psychiatric Institution have been analyzed according to their age, gender, ICD-10 diagnosis, medical evolution, and total number of consultations. A total of 61.5% of the population were male, and they showed a higher average and a wider range of age than female patients. According to the ICD-10 diagnosis, 67.3% were in the group of F40-48 neurotic, stress-related and somatoform disorders, and 11.5% were in the group of F30-39 mood [affective] disorders. Twenty five % of the patients were assumed to have show medical improvement, and 42.3% of the patients continued to have further consultations. This article discusses the possible role of psychiatric medical institutions in supporting cases of school-refusal and social-withdrawal. 相似文献
7.
8.
Mitsuru Koizumi Yasuhiko Yamada Etsuji Nomura Maki Amano Yuji Okajima Hiromi Okizuka Keiko Yamada Seishi Sawano Takashi Kitahara Takashi Yamashita Minoru Nakane Toshio Ishikawa 《Annals of nuclear medicine》1995,9(2):101-104
A case of recurrent medullary thyroid cancer (MTC) was evaluated with123I-MIBG,99mTc(V)-dimercaptosuccinic acid (DMSA), and201Tl scintigraphy. This patient had been operated on for MTC in the right thyroid. Recently a left neck mass was noticed, and was suspected of being a. recurrence of MTC based on increased plasma calcitonin (CT) and carcinoembryonic antigen (CEA). He was operated on for the neck mass which revealed MTC, and papillary thyroid cancer was incidentally found in the left thyroid, but the CT and CEA levels remained high, and remaining MTC tumor was suspected. But the location of the tumor was unknown. Although99mTc(V)-DMSA scintigraphy is generally believed to be superior in sensitivity to123I-MIBG scintigraphy, it did not demonstrate the tumor site but201Tl and123I-MIBG did. Furthermore,123I-MEBG scintigraphy has greater specificity for tumors which arise in the neural crest. Judging from the results of this case and cases reported in the literatures, both123I-MIBG and99mTc(V)-DMSA should be performed in the detection of recurrent MTC. 相似文献
9.
B F Trump T W Jones K A Elliget M W Smith P C Phelps A Maki I K Berezesky 《Renal failure》1990,12(3):183-191
Cellular toxicity and cellular carcinogenesis are closely linked. In the kidney, this relationship has been emphasized by the recent discovery of a number of putatively non-mutagenic chemicals that result in acute and chronic toxicity and ultimately in carcinogenesis, especially in the male rat. Many, but not all such compounds, result in renal PTE phagolysosomal overload. At the same time, known metabolites of other carcinogens, e.g., HCBD and FBPA, result in acute renal injury and/or necrosis, followed by chronic tubular disease, interstitial nephritis, and ultimately carcinogenesis. A series of cell mechanisms have been suggested that lead from acute cell injury to altered control of cell division. These mechanisms appear to involve ion deregulation, (especially [Ca2+]i) resulting from a variety of continued injuries, (e.g., oxidative stress from inflammatory cells) and ultimately leading to altered gene expression. 相似文献
10.