全文获取类型
收费全文 | 4018篇 |
免费 | 190篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 78篇 |
妇产科学 | 59篇 |
基础医学 | 480篇 |
口腔科学 | 114篇 |
临床医学 | 271篇 |
内科学 | 1016篇 |
皮肤病学 | 73篇 |
神经病学 | 300篇 |
特种医学 | 171篇 |
外科学 | 611篇 |
综合类 | 22篇 |
预防医学 | 106篇 |
眼科学 | 53篇 |
药学 | 321篇 |
中国医学 | 6篇 |
肿瘤学 | 517篇 |
出版年
2023年 | 28篇 |
2022年 | 49篇 |
2021年 | 93篇 |
2020年 | 38篇 |
2019年 | 50篇 |
2018年 | 99篇 |
2017年 | 58篇 |
2016年 | 53篇 |
2015年 | 74篇 |
2014年 | 108篇 |
2013年 | 127篇 |
2012年 | 193篇 |
2011年 | 176篇 |
2010年 | 93篇 |
2009年 | 84篇 |
2008年 | 172篇 |
2007年 | 171篇 |
2006年 | 171篇 |
2005年 | 190篇 |
2004年 | 177篇 |
2003年 | 185篇 |
2002年 | 190篇 |
2001年 | 105篇 |
2000年 | 130篇 |
1999年 | 111篇 |
1998年 | 59篇 |
1997年 | 44篇 |
1996年 | 44篇 |
1995年 | 43篇 |
1994年 | 45篇 |
1993年 | 29篇 |
1992年 | 100篇 |
1991年 | 98篇 |
1990年 | 81篇 |
1989年 | 81篇 |
1988年 | 93篇 |
1987年 | 64篇 |
1986年 | 70篇 |
1985年 | 72篇 |
1984年 | 39篇 |
1983年 | 54篇 |
1982年 | 15篇 |
1981年 | 19篇 |
1979年 | 29篇 |
1977年 | 20篇 |
1973年 | 17篇 |
1972年 | 20篇 |
1971年 | 15篇 |
1967年 | 17篇 |
1966年 | 14篇 |
排序方式: 共有4217条查询结果,搜索用时 0 毫秒
1.
Yosuke Homma Takashi Shiga Hiraku Funakoshi Dai Miyazaki Atsushi Sakurai Yoshio Tahara Ken Nagao Naohiro Yonemoto Arino Yaguchi Naoto Morimura 《The American journal of emergency medicine》2019,37(2):241-248
Objective
This study assessed the association between the timing of first epinephrine administration (EA) and the neurological outcomes following out-of-hospital cardiac arrests (OHCAs) with both initial shockable and non-shockable rhythms.Methods
This was a post-hoc analysis of a multicenter prospective cohort study (SOS-KANTO 2012), which registered OHCA patients in the Kanto region of Japan from January 2012 to March 2013. We included consecutive adult OHCA patients who received epinephrine. The primary result included 1-month favorable neurological outcomes defined as cerebral performance category (CPC) 1 or 2. Secondary results included 1-month survival and return of spontaneous circulation (ROSC) after arrival at the hospital. Multivariable logistic regression analysis determined the association between delay per minute of the time from call to first EA in both pre- or in-hospital settings and outcomes.Results
Of the 16,452 patients, 9344 were eligible for our analyses. In univariable analysis, the delay in EA was associated with decreased favorable neurological outcomes only when the initial rhythm was a non-shockable rhythm. In multivariable analyses, delay in EA was associated with decreased ROSC (adjusted odds ratio [OR] for one minute delay, 0.97; 95% confidence interval [CI], 0.96–0.98) and 1-month survival (adjusted OR, 0.95; 95% CI, 0.92–0.97) when the initial rhythm was a non-shockable rhythm, whereas during a shockable rhythm, delay in EA was not associated with decreased ROSC and 1-month survival.Conclusions
While assessing the effectiveness of epinephrine for OHCA, we should consider the time-limited effects of epinephrine. Additionally, consideration of early EA based on the pathophysiology is needed. 相似文献2.
Kazuyoshi Kataoka Katsuo Furukawa Kohichi Nagao Nobuhisa Ishii Hiromichi Tsuru 《International journal of urology》2007,14(8):764-768
AIM: To investigate the participation of adenosine receptors in the adenosine 5'-triphosphate (ATP)-induced relaxation in the corpus cavernosum penis (CCP) of rabbits. METHODS: The ATP-induced relaxation was assessed on the noradrenaline precontracted CCP of rabbits in the presence and absence of 8-(3-chlorostyryl)caffeine (CSC); an adenosine A(2A) receptor antagonist; alloxazine and MRS1754; adenosine A(2B) receptor antagonists; and ARL67156, an inhibitor of ecto-nucleoside triphosphate diphosphohydrolases. RESULTS: Adenosine and ATP relaxed the noradrenaline precontracted CCP of rabbits in a concentration-dependent manner. The adenosine- and ATP-induced relaxations were suppressed by alloxazine and MRS1754, but not by 8-(3-chlorostyryl)caffeine. ARL67156 potentiated the ATP-induced relaxation but not the adenosine-induced one. MRS1754 suppressed the ATP-induced relaxation potentiated by ARL67156. CONCLUSIONS: The above results suggest that, in the CCP of rabbits, the adenosine receptor mediating adenosine-induced relaxation is of the A(2B) receptor and the ATP directly causes relaxation through the A(2B) receptor on the CCP. 相似文献
3.
Histamine-type 2 antagonists (H2-blockers) as represented by cimentidine have been shown to adversely affect renal allograft function, particularly when coadministered
with cyclosporine, currently a major immunosuppressant. To determine whether or not a newer and more powerful H2-blocker, famotidine, would produce similar adverse effects, we assessed seven cyclosporine-treated renal allograft recipients
with regard to changes in their renal function on or off the H2-blocker over a one-week period. Neither the administration nor withdrawal of famotidine (20–40 mg/day) resulted in any significant
changes in serum creatine, BUN, urine output or cyclosporine trough levels, suggesting that famotidine can be safely administered
as an H2-blocker to cyclosporine-treated renal allograft recipients. 相似文献
4.
K. Arima Minako Nakamura Nobuhiko Sunohara Masafumi Ogawa Midori Anno Yoko Izumiyama Shigeo Hirai Kazuhiko Ikeda 《Acta neuropathologica》1997,93(6):558-566
Coiled bodies and interfascicular threads are conspicuous white matter abnormalities of brains of patients with progressive
supranuclear palsy (PSP). Both structures are argyrophilic and immunoreactive for the microtubule-binding protein tau. This
report concerns the ultrastructural localization of interfascicular threads and their relationship to coiled bodies in five
PSP patients. We showed for the first time that abnormal tubules with a 13- to 15-nm diameter and fuzzy outer contours were
the common structures of coiled bodies in the oligodendroglial perikarya and of interfascicular threads. Moreover, the tubules
were immunolabeled by anti-tau antibodies. The abnormal tau-positive tubules of interfascicular threads were located in the
inner loop of the myelin sheath. Our study further indicated that the thread-like structures in the white matter comprised,
at least in part, oligodendroglial processes, and that they were also present in gray matter. We consider that the formation
of coiled bodies in the perikarya and of interfascicular threads represents a common cytoskeletal abnormality of the oligodendroglia
of PSP patients. Moreover, even though the white matter alterations of PSP resemble those of corticobasal degeneration, there
are certain ultrastructural differences in the abnormal oligodendroglial tubules of the two diseases.
Received: 4 October 1996 / Accepted: 6 December 1996 相似文献
5.
6.
Tetsuhiko Nagao Seizo Sadoshima Takao Ishitsuka Kenji Kusuda Osamu Shiokawa Setsuro Lbayashi Masatoshi Fujishima 《Clinical and experimental pharmacology & physiology》1992,19(7):489-493
1. The effects of acute bilateral superior cervical ganglionectomy on cerebral blood flow and metabolism were investigated in stroke-prone spontaneously hypertensive rats (SHRsp), before and during cerebral ischaemia. 2. The resting cerebral blood flow was comparable between the control and denervated animals. 3. There was no significant difference in cerebral blood flow or concentration of tissue energy metabolites (adenosine triphosphate [ATP], lactate and pyruvate) between the sham-operated control and denervated animals during ischaemia. 4. The results suggest that sympathetic innervation of cerebral vessels originating from superior cervical ganglia may not play a major role in the progression of cerebral ischaemia in SHRsp. 相似文献
7.
A human monoclonal antibody (MCA), CLN-IgG, showed cytotoxic effect in vitro against the cervical carcinoma cell line, ME-180, by antibody dependent cell-mediated cytotoxicity (ADCC). To determine which fractions of cells in peripheral blood lymphocyte (PBL) mediate ADCC, PBL were separated with nylon wool column and sheep red blood cells (SRBC). Both adherent cells (monocyte) and non-T, non-B cells showed cytotoxicity by ADCC. Human non-T, non-B cells showed higher cytotoxic activity against ME-180 cells than monocytes. Furthermore murine effector cells were less effective in ADCC than human effector cells with human MCA. 相似文献
8.
9.
S Nagao 《Neuroreport》1992,3(1):13-16
Responses of Purkinje cells were compared in the monkey flocculus and ventral paraflocculus. During vestibuloocular reflex (VOR) eye movements, flocculus Purkinje cells exhibited simple spike modulation related to head velocity, while ventral paraflocculus Purkinje cells exhibited modulation with no such head velocity preference. During smooth tracking of a sinusoidally moving small target, ventral paraflocculus Purkinje cells exhibited simple spike modulation related to target velocity or position, while the flocculus Purkinje cells exhibited a smaller modulation with no such target preference. Visual suppression of the VOR enhanced the simple spike responses in the ventral paraflocculus, but not in the flocculus. These results suggest that the primate flocculus and the ventral paraflocculus control differentially VOR and smooth pursuit eye movements, respectively. 相似文献
10.