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排序方式: 共有453条查询结果,搜索用时 31 毫秒
1.
Dr. Hajo Dirk Weitmann Tomas Hendrik Knocke Claudia Waldhäusl Richard Pötter 《Strahlentherapie und Onkologie》2006,182(2):86-95
BACKGROUND: In advanced vaginal recurrences of cervical and endometrial carcinomas therapeutic options are rare because of preceding therapy. PATIENTS AND METHODS: 23 patients developing advanced vaginal recurrences of cervical and endometrial carcinomas were included. 15 patients started with external-beam therapy to the pelvis and eight patients after preceding radiotherapy underwent brachytherapy alone. All patients had ultrasound-guided implantation of transvaginal or transperineal interstitial needles for brachytherapy. Median prescribed total dose was 64 Gy. RESULTS: 18 patients (78%) achieved complete remission. Six patients are alive without tumor and one with tumor after a median follow-up of 64 months. 14 patients died of tumor and two of intercurrent disease. 5-year disease-specific survival and local control rate were 43% and 47%, respectively, in patients with complete remission. Univariate analysis found time to relapse > 2 years, initial diameter < or = 4 cm, initial volume < 15 cm(3), no extension to the pelvic side wall, volume before brachytherapy < 7.5 cm(3), brachytherapy coverage index > 0.8, and prescribed total dose > 64 Gy being positive predictors for local control and survival. CONCLUSION: The use of ultrasound guidance for placement of interstitial needles in template-based brachytherapy of advanced recurrent gynecologic malignancies is a feasible, safe, and cheap method with encouraging results. Today, ultrasound imaging can be also used to some extent for treatment planning which requires further development. Patient- and treatment-related prognostic factors can be defined. 相似文献
2.
Rooijens PP de Krijger RR Bonjer HJ van der Ham F Nigg AL Bruining HA Lamberts SW van der Harst E 《Endocrine pathology》2004,15(1):39-45
The purpose of this study was to investigate tumor angiogenesis in a series of benign and malignant pheochromocytomas and
to determine whether there is a correlation between angiogenesis and the presence of distant metastases. In this study, the
CD31 monoclonal antibody was selected to measure intratumoral microvessel density. Nineteen patients with malignant pheochromocytomas
and nineteen patients with benign pheochromocytomas who underwent operation were studied. In order to quantify intratumoral
microvessel density, the total number of pixels of CD31-positive reactivity was assessed and expressed as a percentage of
the total tissue area in the analyzed field. Analysis of variance revealed a statistically significant correlation between
malignancy and intratumoral microvessel density (p=0.0009). Although there was a considerable variability in the intratumoral microvessel density from tumor to tumor within
both the benign and the malignant group, a percentage of more than 28.5% anti-CD31 stained area was found only in malignant
tumors. In conclusion, this study shows that the mean intratumoral microvessel density in malignant pheochromocytomas is increased
approximately two-fold as compared with benign tumors. However, the clinical significance of this prognostic marker is rather
weak, because only 4 of the 19 malignant pheochromocytomas had microvesel density higher than this threshold of 28.5%. 相似文献
3.
Hans-Jürgen Rode Joachim Jakob Bugert Michaela Handermann Paul Schnitzler Roland Kehm Waltraud Janssen Hajo Delius Gholamreza Darai 《Virus genes》1994,9(1):61-75
The complete DNA nucleotide sequence of theEcoRI DNA fragment N (0.235 to 0.258 viral map units) of equine herpes virus type 2 (EHV-2) strain T400/3 was determined. This DNA fragment comprises 4237 bp with a base composition of 55.23% G+C and 44.77% A+T. Nineteen open reading frames (ORFs) of 50-287 amino acid (aa) residues were detected. ORF number 10 is located between the nucleotide position 2220 and 2756 coding for a protein of 179 amino acid residues. This protein shows significant homology to the cytokine synthesis inhibitory factor (CSIF; interleukin 10) of human (76.4%) and mouse (68.5%), and to the Epstein-Barr virus (EBV) protein BCRF1 (70.6%). The existence of an interleukin 10 (IL-10) analogous gene within the genome of the EHV-2 was confirmed by screening the genome of nine EHV-2 strains using specific oligonucleotide primers corresponding to the 5 and 3 region of this particular gene by polymerase chain reaction. In all experiments an 870 bp DNA product was amplified. The specifity of the amplified DNA fragments obtained from individual EHV-2 strains was confirmed by DNA-DNA hybridization experiments. The DNA sequence analysis of the amplified DNA products of the EHV-2 strain LK was carried out. This analysis revealed the identity of the corresponding IL-10 gene (540 bp) of this strain to the IL-10 gene of EHV-2 strain T400/3. The presented data indicate that the EHV-2 genome harbors a viral interleukin 10-like gene. This is further evidence that the IL-10 gene can be present in the genomes of members of the Herpesviridae family. 相似文献
4.
Zeeb Hajo Ahrens Wolfgang Haug Ulrike Grabenhenrich Linus Pigeot Iris 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2021,64(9):1076-1083
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Die Epidemiologie als wissenschaftliche Disziplin ist prädestiniert dafür, Kernfragen der COVID-19-Pandemie zu... 相似文献
5.
Hajo Molter 《System Familie》1999,12(4):165-169
Zusammenfassung In diesem Beitrag wird der Unterschied zwischen Selbsterfahrung und Selbstreflexion anhand konstruktivistischer Überlegungen diskutiert. Weiter wird die Bedeutung und Entwicklung der Familienrekonstruktion im Rahmen der Ausbildung am Institut für Familientherapie, Ausbildung und Entwicklung e.V., Weinheim, beschrieben. Systemisches Denken und Handeln in und mit Gruppen sowie das Leitungsverständnis" des Lehrtherapeuten werden thematisiert. Summary In this article the author discusses the differences between self-encounter and self-reflection by using constructivist ideas. Further on, the significance and development of family reconstruction in the context of training at the "Institut für Familientherapie, Ausbildung und Entwicklung e.V., Weinheim," are described. Systemic thinking and acting in and with groups as well as the concept of leading a group are pointed out. 相似文献
6.
7.
Simone Van Der Geer Hajo Reijers Gertruud Krekels 《Journal der Deutschen Dermatologischen Gesellschaft》2010,8(1):15-18
The worldwide incidence of skin cancer (especially non‐melanoma skin cancer) has risen dramatically over the last decades. Skin cancer, including pre‐malignant lesions, is becoming a chronic disease. Adjustments in skin cancer health care need to be made. A disease management system for skin cancer is mandatory in order to avoid waiting lists and insure adequate treatment quality with ever growing numbers of patients requiring treatment. At the Catharina Hospital Eindhoven adjustments are being made on several levels of the dermato‐oncology unit in collaboration with Eindhoven University of Technology. The model combines technological improvements, training health care workers, training of general practitioners and prevention of skin cancer. We discuss our ideas and clinical experiences with managing a dermato‐oncology unit. 相似文献
8.
Hajo Müller M.D. Afksendyios Kalangos M.D. Ph.D. Amir‐Ali Fassa M.D. René Lerch M.D. 《Echocardiography (Mount Kisco, N.Y.)》2010,27(5):E50-E52
We report a case of isolated cleft mitral valve with two clefts in the posterior and one in the anterior leaflet. Our case adds to the few reports of posterior and multiple mitral valve clefts and to our knowledge is the first using real‐time transoesophageal three‐dimensional echocardiography (3DE) for assessment of isolated cleft mitral valve. (Echocardiography 2010;27:E50‐E52) 相似文献
9.
Tjallie van der Kooi Hugo Sax Didier Pittet Jaap van Dissel Birgit van Benthem Bernhard Walder Vanessa Cartier Lauren Clack Sabine de Greeff Martin Wolkewitz Stefanie Hieke Hendriek Boshuizen Jan van de Kassteele Annemie Van den Abeele Teck Wee Boo Magda Diab-Elschahawi Uga Dumpis Camelia Ghita Susan FitzGerald Tatjana Lejko Kris Leleu Mercedes Palomar Martinez Olga Paniara Márta Patyi Paweł Schab Annibale Raglio Emese Szilágyi Mirosław Ziętkiewicz Albert W. Wu Hajo Grundmann Walter Zingg On behalf of the PROHIBIT consortium 《Intensive care medicine》2018,44(1):48-60
Purpose
To test the effectiveness of a central venous catheter (CVC) insertion strategy and a hand hygiene (HH) improvement strategy to prevent central venous catheter-related bloodstream infections (CRBSI) in European intensive care units (ICUs), measuring both process and outcome indicators.Methods
Adult ICUs from 14 hospitals in 11 European countries participated in this stepped-wedge cluster randomised controlled multicentre intervention study. After a 6 month baseline, three hospitals were randomised to one of three interventions every quarter: (1) CVC insertion strategy (CVCi); (2) HH promotion strategy (HHi); and (3) both interventions combined (COMBi). Primary outcome was prospective CRBSI incidence density. Secondary outcomes were a CVC insertion score and HH compliance.Results
Overall 25,348 patients with 35,831 CVCs were included. CRBSI incidence density decreased from 2.4/1000 CVC-days at baseline to 0.9/1000 (p < 0.0001). When adjusted for patient and CVC characteristics all three interventions significantly reduced CRBSI incidence density. When additionally adjusted for the baseline decreasing trend, the HHi and COMBi arms were still effective. CVC insertion scores and HH compliance increased significantly with all three interventions.Conclusions
This study demonstrates that multimodal prevention strategies aiming at improving CVC insertion practice and HH reduce CRBSI in diverse European ICUs. Compliance explained CRBSI reduction and future quality improvement studies should encourage measuring process indicators.10.
Sanjay Cherian Hajo M��ller Afksendiyos Kalangos Mustafa Cikirikcioglu 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2012,39(5):676-679
Structural degeneration is an important long-term disadvantage of biologic prostheses. However, early failure of these prostheses is uncommon and is usually caused by rapid calcification. We report the successful management of a rare case of early failure of a stentless aortic bioprosthesis (within 4 months of implantation). The patient presented with severe noncalcific aortic regurgitation secondary to prolapse of the noncoronary leaflet. In consideration of the acute nature of failure in this new-generation bioprosthesis and its unclear cause, we believe that this report, albeit of a single case, warrants some attention.Key words: Aortic valve insufficiency/surgery, bioprosthesis/failure, complication, disease progression, heart valve prosthesis/failure, reoperationAortic valve replacement using stentless biological prostheses offers the benefits of good hemodynamics,1 without the requirement of prolonged anticoagulation.2 Although their major drawback—structural degeneration in the long term—is well documented,3 bioprostheses rarely fail early, and, when they do, rapid calcification of the valve leaflets is the usual cause.4
We report the successful management of a rare case of early failure of a stentless aortic bioprosthesis within 4 months of implantation. The patient presented with severe noncalcific aortic regurgitation secondary to prolapse of the noncoronary leaflet. 相似文献