全文获取类型
收费全文 | 57453篇 |
免费 | 5509篇 |
国内免费 | 4416篇 |
专业分类
耳鼻咽喉 | 527篇 |
儿科学 | 662篇 |
妇产科学 | 662篇 |
基础医学 | 7154篇 |
口腔科学 | 1001篇 |
临床医学 | 7782篇 |
内科学 | 8860篇 |
皮肤病学 | 608篇 |
神经病学 | 2959篇 |
特种医学 | 2089篇 |
外国民族医学 | 35篇 |
外科学 | 5593篇 |
综合类 | 9354篇 |
现状与发展 | 16篇 |
一般理论 | 10篇 |
预防医学 | 3860篇 |
眼科学 | 1582篇 |
药学 | 6054篇 |
50篇 | |
中国医学 | 3233篇 |
肿瘤学 | 5287篇 |
出版年
2024年 | 197篇 |
2023年 | 941篇 |
2022年 | 2435篇 |
2021年 | 3125篇 |
2020年 | 2380篇 |
2019年 | 1992篇 |
2018年 | 2128篇 |
2017年 | 1981篇 |
2016年 | 1837篇 |
2015年 | 2679篇 |
2014年 | 3421篇 |
2013年 | 2928篇 |
2012年 | 4279篇 |
2011年 | 4688篇 |
2010年 | 2865篇 |
2009年 | 2287篇 |
2008年 | 3000篇 |
2007年 | 3028篇 |
2006年 | 2855篇 |
2005年 | 2954篇 |
2004年 | 1904篇 |
2003年 | 1762篇 |
2002年 | 1565篇 |
2001年 | 1280篇 |
2000年 | 1201篇 |
1999年 | 1269篇 |
1998年 | 904篇 |
1997年 | 825篇 |
1996年 | 664篇 |
1995年 | 641篇 |
1994年 | 532篇 |
1993年 | 339篇 |
1992年 | 424篇 |
1991年 | 354篇 |
1990年 | 282篇 |
1989年 | 270篇 |
1988年 | 283篇 |
1987年 | 201篇 |
1986年 | 175篇 |
1985年 | 132篇 |
1984年 | 69篇 |
1983年 | 76篇 |
1982年 | 34篇 |
1981年 | 38篇 |
1980年 | 23篇 |
1979年 | 33篇 |
1978年 | 12篇 |
1977年 | 10篇 |
1973年 | 11篇 |
1971年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
目的以基因表达数据集资料为研究对象,分析BCAN基因在肾透明细胞癌中的表达情况以及对患者预后的影响。方法在Oncomine数据库中挖掘BCAN在肾透明细胞癌(ccRCC)中的表达情况。从TCGA数据库中获取ccRCC患者临床资料和目的基因的表达信息并进行统计分析。利用GEO数据库中GSE73731数据集的ccRCC样本进行基因富集分析。利用String数据库分析与BCAN相关的蛋白。结果BCAN低表达组的ccRCC患者在病理分期及T分期方面低于高表达组(P<0.001;P=0.001);N分期及M分期差异无统计学意义(P>0.05)。BCAN低表达组患者的总生存期优于高表达组(P=0.033)。BCAN基因高表达组的样本主要富集在KRAS信号通路。结论BCAN可以通过多种途径来促进肿瘤细胞的侵袭能力,有望成为ccRCC不良预后的重要生物标志物之一。 相似文献
2.
3.
观察电针对缺血性脑卒中大鼠记忆功能及脑内突触囊泡蛋白(synaptic vesicular protein,SYN)的影响,探讨其可能的作用机制。方法 选取90 只SD大鼠随机分为模型组、电针组、假手术组,每组各30只。线拴法制作急性大脑中动脉缺血大鼠模型。电针组取“百会”“水沟”“内关”“三阴交”穴位,应用“醒脑开窍”法进行电针,每天电针30 min,连续电针6 d休1 d,7 d为一个疗程,首次电针干预在造模成功24 h后进行。模型组和假手术组不进行电针干预。大鼠分别按7、14、21 d 3个亚组进行运动及记忆功能评分,TTC染色测定脑梗死体积、Western blot检测脑内SYN的蛋白表达。结果 电针组运动功能评分较模型组显著降低(P<0.01),电针组进入隐藏区潜伏期时间较模型组显著缩短(P<0.01),电针组脑梗死率较模型组显著缩小(P<0.01),SYN的蛋白表达电针组较模型组明显增强(P<0.01)。假手术组无神经功能缺损及脑梗死灶,SYN表达最弱。结论 电针干预能减小脑梗死体积,上调脑内SYN的表达,进而促进缺血性脑卒中大鼠的记忆及运动等神经功能的恢复。 相似文献
4.
Richard Kim Elaine Tan Emily Wang Amit Mahipal Dung-Tsa Chen Biwei Cao Fadzai Masawi Cindy Machado James Yu Dae Won Kim 《The oncologist》2020,25(12):e1893-e1899
Lessons Learned
- The combination of trametinib and sorafenib has an acceptable safety profile, albeit at doses lower than approved for monotherapy.
- Maximum tolerated dose is trametinib 1.5 mg daily and sorafenib 200 mg twice daily.
- The limited anticancer activity observed in this unselected patient population does not support further exploration of trametinib plus sorafenib in patients with hepatocellular carcinoma.
5.
6.
Shengxuan Cao Chen Wang Xin Ma Xu Wang Jiazhang Huang Chao Zhang Li Chen Xiang Geng Kan Wang 《Journal of orthopaedic research》2019,37(8):1860-1867
Patients with mechanic ankle instability experience increased tibiotalar and subtalar joint laxity. However, in vivo joint kinematics in functional ankle instability (FAI) patients and lateral ankle sprain (LAS) copers, especially during dynamic activities, are poorly understood. Ten FAI patients, 10 LAS copers, and 10 healthy controls were included in this study. A dual fluoroscopic imaging system was used to analyze the tibiotalar and subtalar joint kinematics during stair descent. Five key poses of stair descent were analyzed. Kinematic data from six degrees of freedom were calculated utilizing a solid modeling software. The range of motion and joint positions in each degree of freedom were compared among the three groups. The tibiotalar joints of FAI patients and LAS copers were significantly more inverted than those of healthy controls during the foot strike (p = 0.016, = 0.264). The subtalar joints of FAI patients were significantly more anteriorly translated (pose 2, p = 0.003, = 0.352; pose 3, p < 0.001, = 0.454; pose 4, p = 0.004, = 0.334), inverted (pose 4, p = 0.027, = 0.234; pose 5,p = 0.034, = 0.221), and externally rotated (pose 4, p = 0.037, = 0.217; pose 5; p = 0.004, = 0.331) than those of healthy controls during the mid‐stance and the heel off. The FAI patients showed excessive tibiotalar inversion and subtalar joint hypermobility during stair descent. Meanwhile, the LAS copers maintained subtalar joint stability, and only showed excessive tibiotalar inversion in foot strike. These data provide insight into the mechanisms behind the development of FAI after initial LAS. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1860–1867, 2019 相似文献
7.
8.
9.
Yuan Peng Yuman Li Haiyan Cao Liu Hong Yu Wang Mingxing Xie 《Journal of ultrasound in medicine》2019,38(2):539-544
A pulmonary artery (PA) sling is a very rare congenital cardiovascular anomaly, and only a few studies have reported PA slings in fetuses. The relationship of the PA, aorta, ductus arteriosus, and trachea can be evaluated in the 3‐vessel and 3‐vessel and trachea views during fetal echocardiography. A PA sling can be detected by abnormal positioning of the left PA in relation to the trachea when sweeping from the 3‐vessel view cranially to the 3‐vessel and trachea view. Here we report 3 cases of fetal PA slings and their follow‐ups. Two cases were confirmed by postnatal echocardiography, and the other case was confirmed by a cardiovascular cast after pregnancy termination. We emphasize that the 3‐vessel and 3‐vessel and trachea views are of crucial importance in the prenatal diagnosis of a PA sling. 相似文献
10.
Kui Li Jiawen Wang Shengxiong Liu Sen Su Chenjian Feng Xiaoxiang Fan Zhiyong Yin 《中华创伤杂志(英文版)》2015,18(2):65-73
Objective: To study the biomechanical mechanism of head injuries beaten with sticks, which is common in the battery or assaultive cases.
Methods: In this study, the Hybrid-III anthropomorphic test device and finite element model (FEM) of the total human model for safety (THUMS) head were used to determine the biomechanical response of head while being beaten with different sticks. Total eight Hybrid-III tests and four finite element simulations were conducted. The contact force, resultant acceleration of head center of gravity, intracranial pressure and von Mises stress were calculated to determine the different biomechanical behavior of head with beaten by different sticks.
Results: In Hybrid-III tests, the stick in each group demonstrated the similar kinematic behavior under the same loading condition. The peak values of the resultant acceleration for thick iron stick group, thin iron stick group, thick wooden stick group and thin wooden stick group were 203.4 g, 221.1 g, 170.5 g and 122.2 g respectively. In finite element simulations, positive intracranial pressure was initially observed in the frontal comparing with negative intracranial pressure in the contra-coup site. Subsequently the intracranial pressure in the coup site was decreasing toward negative value while the contra-coup intracranial pressure increasing toward positive values.
Conclusions: The results illustrated that the stiffer and larger the stick was, the higher the von Mises stress, contact force and intracranial pressure were. We believed that the results in the Hybrid-III tests and THUMS head simulations for brain injury beaten with sticks could be reliable and useful for better understanding the injury mechanism. 相似文献