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Studies evaluating the relationship between microbes and human health at non-point source beaches are necessary for establishing criteria which would protect public health while minimizing economic burdens. The objective of this study was to evaluate water quality and daily cumulative health effects (gastrointestinal, skin, and respiratory illnesses) for bathers at a non-point source subtropical marine recreational beach in order to better understand the inter-relationships between these factors and hence improve monitoring and pollution prevention techniques. Daily composite samples were collected, during the Oceans and Human Health Beach Exposure Assessment and Characterization Health Epidemiologic Study conducted in Miami (Florida, USA) at a non-point source beach, and analyzed for several pathogens, microbial source tracking markers, indicator microbes, and environmental parameters. Analysis demonstrated that rainfall and tide were more influential, when compared to other environmental factors and source tracking markers, in determining the presence of both indicator microbes and pathogens. Antecedent rainfall and F+ coliphage detection in water should be further assessed to confirm their possible association with skin and gastrointestinal (GI) illness outcomes, respectively. The results of this research illustrate the potential complexity of beach systems characterized by non-point sources, and how more novel and comprehensive approaches are needed to assess beach water quality for the purpose of protecting bather health.  相似文献   
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Introduction

Susceptibility weighted (SW) magnetic resonance imaging (MRI) can visualize the vein/s around which multiple sclerosis (MS) plaques are centered. This study's purpose was to assess the ability of the central vein sign (CVS) to differentiate MS plaques from non MS white matter lesions (WMLs).

Methods

Out of 18 patients, 9 had MS, 3 had systemic lupus erythematosus, 4 had hypertensive microangiopathy and 2 had Behcet’s disease. 3?T MRI examination was performed to obtain fluid attenuated inversion recovery (FLAIR) and the SW images. Lesions more than 3?mm were identified and analyzed for location and existence of the CVS.

Results

Out of 572 MS lesions, 281 lesions were positive for the CVS, while only 66 out of 279 non MS lesions were CVS positive with a statistically significant difference between the two groups (p?<?0.001). As regards the percentage of perivenous lesions per patient; using a cutoff value of 30%, MRI accurately segregated all patients with MS and 8/9 non MS patients.

Conclusion

Though the CVS is not found solely in MS lesions it is more frequent in MS WMLs as compared to non MS WML and thus is reliable adjunctive tool in differentiation of MS plaques from WMLs of alternative etiologies.  相似文献   
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Aim of the work

To present the clinical and laboratory disease characteristics in Egyptian patients with progressive systemic sclerosis (SSc) and their nail fold capillaroscopy findings.

Patients and methods

50 SSc patients were included. For all patients detailed history taking and clinical and rheumatological examination were performed. The modified Rodnan skin score (mRSS) and nail fold capillaroscopy were assessed.

Results

The mean age was 41.4?±?12.7?years (range 16–67?years) and median disease duration was 5?years (range 1–40?years). Eight patients (16%) were males and 42 (84%) females (M:F 1:5.25). Skin tightness was present in all patients; mean mRSS was 17.5?±?10.4 (ranges 4–45). 44 (88%) patients had abnormal pulmonary function tests; 42 (84%) restrictive and 2 (4%) obstructive; 25 (50%) presented with interstitial lung disease. Pulmonary artery hypertension was recorded in 9 (18%) patients. Renal manifestations were the least common recorded system involvement (20%). Antinuclear antibodies were positive in 98%, rheumatoid factor in 4%, antitopoisomerase I in 36% and anticentromere in 8% of patients. 96% of patient had abnormal nail fold capillaroscopy. There was a significant negative correlation between mRSS with forced expiratory volume (r?=??0.46, p?=?0.001), forced volume capacity (r?=??0.47, p?=?0.001) and positively with the FEV1/FVC (r?=?0.3, p?=?0.035).

Conclusion

Almost all patients have ANA seropositivity, abnormal PFTs and abnormal nailfold capillaroscopy. Antitopoisomerase I antibody seropositivity, ILD, abnormal PFT, worsening skin score, late pattern of nailfold capillaroscopy are more common in dcSSc. Extensive clinical examination and investigations should be considered for early diagnosis and follow up of Egyptian SSc patients.  相似文献   
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Tumor Biology - Fibroblast growth factor 18 (FGF18) has been suggested to play important roles in promoting progression of ovarian high-grade serous carcinoma. Our aim was to investigate FGF18...  相似文献   
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International Ophthalmology - To evaluate differences in the subjective aniseikonia and stereoacuity in patients with axial anisometropia after full correction of the refractive error with...  相似文献   
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The hazards of plastic waste (PW) from polymers (e.g., polyethylene terephthalate (PET), high-density polyethylene (HDPE), low-density polyethylene (LDPE), polyvinyl chloride (PVC), nylon, polystyrene (PS), etc.), the mechanism of its spread in general, and its ubiquity in our daily lives as a continuously and/or frequently expelled product are a crisis of the twenty-first century, as reported by the United Nations in 2019, especially after the outbreak of the COVID-19 pandemic. This research included the process of modifying the rheological properties of asphalt to obtain asphalt suitable for use in a high-humidity atmosphere. The Iraqi climate is characterized by heat that reaches the point of harshness in the summer and coldness that falls below zero on some winter days. From this point of view, our recent study focuses mainly on making rheological and chemical modifications to asphalt using spent polymeric materials and used lubricating oils (ULO), thus achieving two important goals, namely obtaining asphalt with rheological properties resistant to the Iraqi atmosphere as well as eliminating both solid and liquid environmental pollutants. The microstructure and morphology of the designed patches were characterized using scanning electron microscopy (SEM) to indicate phase composition.  相似文献   
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