平喘止咳贴辅助治疗婴幼儿喘型肺炎60例临床观察

目的观察经皮穴位给药联合西药治疗婴幼儿喘型肺炎的疗效。方法120例喘型肺炎随机分为对照组60例和治疗组60例,对照组相应给予抗病毒、抗菌及对症治疗;治疗组在此基础上,采用贵州康琦公司提供的平喘止咳贴(苗药巴布剂)经皮穴位敷贴。结果治疗组在平均退热时间、干啰音消失时间、湿啰音消失时间、临床症状全部消失时间、住院时间方面与对照组比较,差异有高度统计意义(P<0.01)。治疗组总有效率也优于对照组(P<0.05)。结论中药穴位外敷对婴幼儿喘型肺炎有较好的疗效。     

恶性肿瘤标记物─—~（131）碘－血卟啉衍生物的制备

利用１３１碘标记的血卟啉衍生物（ＨｐＤ）提高恶性肿瘤诊断的灵敏度，以明确肿瘤部位、大小及转移范围。本文介绍了１３１Ｉ─ＨｐＤ的制备方法，并对反应条件进行了讨论。标记品的比活度为６．７ＭＢｑ／ｍｇ，放化纯度＞９２％。可供动物药理等基础研究之用。     

孕期低水平铅暴露与婴儿的行为发育

目的 观察孕期低水平铅暴露对婴儿行为发育的影响。方法 检测孕中期、产母及脐血铅水平并与3月龄的Bayley婴儿行为记录量表得分进行相关分析,以产母血铅及脐血铅水平的第70百分位(0.254μml/L)为分界点、分为相对高铅组及低铅组、进行t检验。结果 3月龄的Bayley婴儿行为记录的30项行为评分中有6项与孕期的铅暴露水平呈负相关关系;产母血铅高、低血铅组间婴儿的社交能力、持久和协调性差异有显著性。结论 孕期铅暴露即使在较低的水平也可能对婴儿的行为发育产生不良影响。     

Repeated measurement sampling in genetic association analysis with genotyping errors

Genotype misclassification occurs frequently in human genetic association studies. When cases and controls are subject to the same misclassification model, Pearson's chi-square test has the correct type I error but may lose power. Most current methods adjusting for genotyping errors assume that the misclassification model is known a priori or can be assessed by a gold standard instrument. But in practical applications, the misclassification probabilities may not be completely known or the gold standard method can be too costly to be available. The repeated measurement design provides an alternative approach for identifying misclassification probabilities. With this design, a proportion of the subjects are measured repeatedly (five or more repeats) for the genotypes when the error model is completely unknown. We investigate the applications of the repeated measurement method in genetic association analysis. Cost-effectiveness study shows that if the phenotyping-to-genotyping cost ratio or the misclassification rates are relatively large, the repeat sampling can gain power over the regular case-control design. We also show that the power gain is not sensitive to the genetic model, genetic relative risk and the population high-risk allele frequency, all of which are typically important ingredients in association studies. An important implication of this result is that whatever the genetic factors are, the repeated measurement method can be applied if the genotyping errors must be accounted for or the phenotyping cost is high.     

上纵隔肿瘤的CT诊断

目的研究上纵隔区域肿瘤的CT征象,提高诊断准确性。方法回顾分析42例经病理证实的上纵隔常见肿瘤的CT表现,包括胸腺瘤、胸内甲状腺肿、恶性淋巴瘤、支气管囊肿及神经源肿瘤。所有患者均经CT平扫检查,35例增强扫描。结果定位正确者40例(95%),定性正确者37例(88%)。结论上纵隔内肿瘤种类较多,CT诊断定位定性的准确率均较高,可作为上纵隔肿瘤影像学检查的首选方法。     

脑静脉血栓螺旋CT的临床应用

目的探讨脑静脉螺旋CT(SCT)对脑静脉血栓(CVT)的诊断价值。资料与方法对20例l临床怀疑或随诊CVT的患者行脑静脉SCT检查，以原始图像为主结合各种重建图像，并与MRI、MRV、脑静脉DSA对照分析。结果脑静脉SCT对中至大的脑静脉(窦)显示率达90％-100％。20例中，确诊为CVT11例，急性期2例合并脑水肿1例，随诊亚急性和慢性血栓再通9例，另9例排除了CVT可能。结论脑静脉SCT是诊断脑静脉病变可靠、有效和快捷的检查方法，尤其对急性或慢性期CVT的诊断，CVT治疗后随诊，以及脑水肿、脑出血等脑实质并发症的显示更为准确。     

62例急性有机磷农药中毒病人的抢救护理

有机磷农药中毒一经确诊,应积极采取有效的急救措施及相应的护理对策,以提高抢救成功率.我院2000年6月-2004年12月收治口服有机磷农药中毒病人62例,现将护理介绍如下.……     

Immunogenicity and safety of a China-made monovalent pandemic (H1N1) 2009 influenza A vaccine in healthcare workers in Guangzhou, China

Because healthcare workers played an important role in the battle against novel pandemic (H1N1) 2009 influenza, a clinical study was conducted to examine the immunogenicity and safety of a single dose of a China-made monovalent, split-virus, pandemic (H1N1) 2009 influenza vaccine in this special high-risk population. Healthcare workers in the First Affiliated Hospital of Guangzhou Medical College who received the pandemic (H1N1) 2009 influenza vaccine were prospectively enrolled. Antibody titers were measured at enrollment and 14 days later using hemagglutination-inhibition (HI) and microneutralization assays. Adverse events were recorded within 7 days and 6 months after vaccination. Double sera were provided by 51 of 65 enrolled subjects. Postvaccination titers of 1:40 or more on HI assay were observed in 96% of recipients. Seroconversion or a significant increase in titer on HI assay occurred in 59% of subjects. The factor increase in GMTs was 4.3. The majority of complaints were mild to moderate in intensity. Although more than half of healthcare workers seemed immune to the pandemic (H1N1) influenza A virus before vaccination, most of the subjects still showed a fast, robust immune response to a single 15-μg dose of a monovalent, split-virus unadjuvanted pandemic H1N1 2009 influenza vaccine.     

脑干听觉诱发电位检查在后循环缺血诊断中的应用

目的探讨脑干听觉诱发电位（BAEP）检查在后循环缺血（PCI）患者中的应用价值。方法回顾分析驻马店市中心医院脑电图室2008～2012年PCI患者96例（PCI组）的BAEP检查结果,并与同期80例健康对照组进行对比。结果 PCI组患者Ⅰ、Ⅲ、Ⅴ波的平均潜伏期（PL）分别为（1.80±0.22）、（3.92±0.29）、（6.12±0.26）ms,Ⅰ～Ⅲ和Ⅲ～Ⅴ波平均峰间潜伏期（IPL）分别为（2.16±0.39）ms和（2.23±0.21）ms;健康对照组Ⅰ、Ⅲ、Ⅴ波平均PL分别为（1.75±0.20）、（3.79±0.25）、（5.98±0.23）ms,Ⅰ～Ⅲ和Ⅲ～Ⅴ波平均IPL分别为（2.19±0.30）ms和（1.67±0.19）ms。PCI组患者Ⅲ、Ⅴ波PL和Ⅲ～Ⅴ波IPL长于健康对照组,差异有统计学意义（P〈0.05）。PCI组Ⅲ、Ⅴ波PL和Ⅲ～Ⅴ波IPL大于健康对照组2.5个标准差;PCI组患者中,BAEP异常84例,异常率为87.5%,主要异常表现为Ⅲ、Ⅴ波PL和Ⅲ～Ⅴ波IPL延长,（Ⅲ～Ⅴ）/（Ⅰ～Ⅲ）的IPL比值〉1,表现以脑干型为主（45/96,46.8%）,高于内耳型（20/96,20.8%）和混合型（31/96,32.2%）。结论 BAEP检查能灵敏地检测出PCI患者的神经电生理异常,可对PCI的诊断提供重要的参考。     

Effect of oral administration of terephthalic acid on testicular functions of rats

To investigate the toxic effect of terephthalic acid (TPA) on testicular functions of rats, male Sprague-Dawley rats were orally administered TPA in diet at the levels 0 (control), 0.2, 1 and 5% for 90 days. Testicular functions were assessed by histopathology, testicular sperm head counts, daily sperm production, sperm motility (measured by computer-assisted sperm analysis, CASA), biochemical indices (marker testicular enzymes), and serum testosterone. Oral feeding with terephthalic acid did not cause body and testes weight loss in TPA-treated groups. Histopathologically, damages of spermatogenic cells and Sertoli cells were observed by electron microscope, testicular sperm head counts, daily sperm production, and activities of sorbitol dehydrogenase (SDH) were decreased significantly in the 5% TPA group. The motility of spermatozoa was reduced significantly in all treated groups, which was correlated with administration doses. Serum testosterone concentrations were not declined in treated groups. In conclusion, TPA can cause impairment of testicular functions. The primary sites of action may be spermatogenic cells and Sertoli cells. The results of the present study provide first information of TPA on testicular functions in male rats.