王晞星辨治大肠癌肝转移经验

介绍王晞星教授辨治大肠癌肝转移的临床经验。认为大肠癌肝转移的根本病机为肝脾两虚、痰瘀毒结;临证以调和肝脾为重,减毒消癥为辅,标本兼顾,攻补兼施;研创特色方药补中调肝汤,和法抗癌,疗效显著。并附验案1则。     

基于TGF-β1/p38MAPK/FN信号通路的放射性食管炎发病机制的研究

Objective To investigate the pathogenesis mechanism of radiation esophagitis from the perspective of mucosal regeneration and to determine whether it is associated with TGF-β1/p38MAPKs/FN signaling pathway. Methods The pathological analysis of esophageal specimens was performed by HE staining method. The expression of FN and TGF-β1 genes were observed by real time-PCR method, and the expression of tissue proteins TGF-β1, p38 and FN were detected by Western blot. Results The weights, food intakes and water intakes at the first week after the occurrence of radiation esophagitis were significantly decreased (P<0.05) and recovered at the fourth week. The esophageal mucosa was destructed at the first and second weeks, and the regeneration occurred in the fourth weeks; TGF-β1 and p38MAPK protein expression increased first and then decreased, while FN protein expression decreased first and then increased. Conclusion The TGF-β1/p38MAPK/FN signaling pathway may be involved in the process of mucosal repair. © 2020, CHINA RESEARCH ON PREVENTION AND TREATMENT. All rights reserved.     

中药逆转胃癌多药耐药研究进展

胃癌是我国主要恶性肿瘤之一，发病率在恶性肿瘤中占首位。化疗是主要治疗方法。但是，肿瘤的多药耐药（muhidrug resistance，MDR）使胃癌化疗的疗效大受影响，近年来许多学者把目光转向天然药物。中药具有毒性小、安全有效的特点，能够从多途径、多机制逆转MDR，本身具有抗肿瘤的作用，能多靶位、多环节抑制肿瘤的发生、发展与转移。笔者就近年来中药逆转胃癌MDR的研究情况作简要概述。     

泰安地区7125例变态反应病人病历分析

为了探索泰安地区变态反应病的特点及其致敏原,现将我院近10年医治的,本地区资料较完整的7125例变态反应病人病历分析如下。1 资料与方法资料均来源于我院变态反应科,对1985年3月至1994年11月门诊诊治病人均按变态反应病要求作病案记录。项目包括:地址、姓名、性别、年龄、职业、初诊日期、病史特点。     

王晞星教授治疗胃癌经验

王晞星教授,山西省中医院院长,享受国务院政府津贴专家,博士生导师,全国第四批老中医药专家学术经验继承指导老师,国家中医肿瘤病学重点学科带头人。从事中医药治疗肿瘤的临床工作30余载,学养深厚,经验丰富,在治疗胃癌方面独有心得,临床疗效卓著。笔者有幸随师临证,略有体会,介绍如下。     

放射性直肠炎(肠澼)中医诊疗专家共识(2017版)

正放射性直肠炎(radiation proctitis,RP)是接受骨盆内脏器放疗患者的常见并发症。近年来,随着放射治疗在盆腔恶性肿瘤的普遍应用,放射性直肠炎的发病逐渐增多~([1])。大量临床研究显示,中医药治疗本病方法较多,疗效确切~([2-4])。然而放射     

王晞星方证对应治疗顽固性口腔溃疡经验

顽固性口腔溃疡病情迁延,缠绵难愈,不易治疗。临床上很多医生喜投清热解毒、苦寒清下之剂,常常不能奏效,反耗伤正气,贻误病情。王晞星教授根据患者不同的病因、病机及治疗过程中出现的病机转化分阶段治疗。准确辨证,方证对应,每每获得良效。