甲状腺功能减退患者太渊穴伏安特性

目的观察甲状腺功能减退患者太渊穴伏安特性变化特征,为穴位功能特异性研究和穴位辅助诊断提供实验依据。方法应用智能型穴位伏安特性检测仪,检测35例甲状腺功能减退患者及40名健康志愿者双侧太渊穴和对照点的伏安曲线,并对其伏安面积和惯性面积进行对比分析。结果健康人双侧太渊增程伏安面积、减程伏安面积均显著小于对照点(P0.01,P0.05),右太渊的惯性面积显著小于对照点(P0.05);甲状腺功能减退患者双侧太渊穴的增程伏安面积、减程伏安面积均显著小于对照点(P0.05,P0.01),而惯性面积与对照点比较差异无统计学意义(P0.05);甲状腺功能减退患者双侧太渊穴的惯性面积均显著大于健康人(P0.05)。结论甲状腺功能减退患者太渊穴伏安特性发生了明显改变,太渊穴是治疗甲状腺机能减退的有效穴位;穴位与脏腑的联系比非穴对照点与脏腑的联系更为密切。     

温和灸对肾俞穴血流灌注量的影响

目的观察温和灸肾俞穴血流灌注量的动态变化规律。方法采用激光散斑血流成像系统,检测温和灸前后20名健康试验对象肾俞穴的血流灌注量变化,检测时间分别为艾灸前、艾灸5min、艾灸10min、艾灸15min、艾灸20min、艾灸后5min、艾灸后10min、艾灸后15min,共8个时间点。结果肾俞穴的基础血流灌注量小于对照点(P0.05);艾灸5min、艾灸10min、艾灸15min、艾灸20min、艾灸后5min、艾灸后10min、艾灸后15min肾俞穴血流灌注量高于艾灸前(P0.05);艾灸20 min肾俞穴血流灌注量高于艾灸5 min(P0.05)。结论艾灸肾俞穴可以引起局部血流量的增加,且存在后续效应,可以改善局部微循环。     

Effect of reward alteration following acupuncture for morphine withdrawal rats on neuronal discharges in the ventral medial prefrontal cortex

Objective

To observe the effect of reward alteration following acupuncture for morphine withdrawal rats on the behavior and neuronal discharges in the medial prefrontal cortex (mPFC).

Methods

The Sprague-Dawley (SD) rats were randomly allocated into a model group, a confinement group, an electroacupuncture (EA) group, and a control group. Rats with morphine addiction were made by intraperitoneal injection of naloxone (same dose injection of saline for rats in the control group), followed by a 2-week morphine withdrawal. Acupuncture and confinement were completed during the morphine withdrawal period. Upon withdrawal, the rats received conditioned place preference (CPP) training and open field test. The multi-channel neural signal processor was used in the electrophysiological experiment to measure the neuronal discharges in different subareas of prefrontal cortex in CPP box and aversion box.

Results

Rats in the model group and the confinement group spent longer period of time in CPP box than those in the EA group and the control group (all P<0.01); there was no statistically significant difference between the EA group and the control group. The total distances of movement by rats in the model group and the confinement group were longer than those in the EA group and the control group (all P<0.01). The mPFC neuronal discharge frequencies were compared between morphine preference box and aversion box. The mPFC neuronal discharge frequencies in the model group and the confinement group were higher than those in the EA group and the control group (all P<0.05); there was no statistically significant difference between the EA group and the control group.

Conclusion

Acupuncture can effectively interfere with the reward alteration following morphine withdrawal, possibly because of its involvement with the mPFC neuronal discharges.