加减暖肝煎胶囊治疗冠心病不稳定性心绞痛33例临床研究

目的：观察加减暖肝煎胶囊对冠心病不稳定性心绞痛的治疗作用。方法：66例冠心病患者随机分为治疗组33例和对照组各33例，连续用药3周。结果：治疗后治疗组在减少心绞痛发作、改善异常心电图方面优于对照组(P＜0．05)，心肌耗氧量也明显减少(P＜0．05)，且能降低血浆TXB2水平，升高6—K—PGFlα水平(P＜0．01)。结论：加减暖肝煎胶囊对不稳定性心绞痛具有较好的治疗作用。提示可从肝入手治疗不稳定性心绞痛。     

Treatment of Unstable Angina Pectoris with Modified Nuan Gan Jian-A Report of 33 Cases

Objective: To observe the effectiveness of Modified Nuan Gan Jian Jiao Nang (MNGJ 加减暖肝煎胶囊Modified Liver-Warming Capsule) in treating unstable angina pectoris. Method: Sixty-six eligible cases were assigned randomly into a treatment group and a control group and treated for 3 weeks. Results:MNGJ produced an effect in reducing episodes, improving the abnormal findings in electro-cardiogram (ECG) (P＜0.05) significantly, and decreasing myocardial oxygen consumption (P＜0.05). In addition, it could decrease the plasma TXB2 level and increase 6-keto-prostaglandin F1α (6-Keto-PGF1α) level (P＜0.01). Conclusion: MNGJ was quite effective in treating unstable angina pectoris, suggesting that the treatment of the disease could start from the liver.     

加减暖肝煎胶囊治疗不稳定性心绞痛的临床研究及理论探讨

目的 :探讨中药复方加减暖肝煎胶囊对冠心病不稳定性心绞痛的治疗作用及其作用机制。方法 :6 6例冠心病不稳定性心绞痛患者随机分为加减暖肝煎胶囊组 33例和对照组 33例 ,连续用药 3周。结果 :治疗后加减暖肝煎胶囊组在减少心绞痛发作 ,改善异常心电图 ,降低心肌耗氧量方面优于对照组 (P <0 0 5 ) ,两组治疗后症状综合评分下降 (P <0 0 1) ,但治疗组下降幅度大于对照组 (P <0 0 1)。结论 :合用加减暖肝煎胶囊治疗不稳定性心绞痛比单用西药效果好 ,加减暖肝煎胶囊对不稳定性心绞痛具有较好的治疗作用。提示可从肝入手治疗不稳定性心绞痛 ,结果为中医隔治法提供了有益的探讨。