全文获取类型
收费全文 | 9341篇 |
免费 | 617篇 |
国内免费 | 131篇 |
专业分类
耳鼻咽喉 | 181篇 |
儿科学 | 310篇 |
妇产科学 | 147篇 |
基础医学 | 1286篇 |
口腔科学 | 319篇 |
临床医学 | 891篇 |
内科学 | 1660篇 |
皮肤病学 | 234篇 |
神经病学 | 971篇 |
特种医学 | 331篇 |
外国民族医学 | 2篇 |
外科学 | 1237篇 |
综合类 | 445篇 |
现状与发展 | 1篇 |
一般理论 | 3篇 |
预防医学 | 560篇 |
眼科学 | 196篇 |
药学 | 661篇 |
4篇 | |
中国医学 | 144篇 |
肿瘤学 | 506篇 |
出版年
2024年 | 7篇 |
2023年 | 79篇 |
2022年 | 150篇 |
2021年 | 320篇 |
2020年 | 191篇 |
2019年 | 243篇 |
2018年 | 262篇 |
2017年 | 263篇 |
2016年 | 303篇 |
2015年 | 356篇 |
2014年 | 465篇 |
2013年 | 530篇 |
2012年 | 703篇 |
2011年 | 629篇 |
2010年 | 383篇 |
2009年 | 328篇 |
2008年 | 479篇 |
2007年 | 536篇 |
2006年 | 544篇 |
2005年 | 463篇 |
2004年 | 556篇 |
2003年 | 555篇 |
2002年 | 434篇 |
2001年 | 295篇 |
2000年 | 208篇 |
1999年 | 153篇 |
1998年 | 106篇 |
1997年 | 79篇 |
1996年 | 45篇 |
1995年 | 33篇 |
1994年 | 24篇 |
1993年 | 27篇 |
1992年 | 35篇 |
1991年 | 19篇 |
1990年 | 15篇 |
1989年 | 29篇 |
1988年 | 29篇 |
1987年 | 17篇 |
1986年 | 30篇 |
1985年 | 11篇 |
1984年 | 17篇 |
1983年 | 12篇 |
1982年 | 9篇 |
1980年 | 10篇 |
1979年 | 11篇 |
1978年 | 8篇 |
1974年 | 9篇 |
1972年 | 9篇 |
1969年 | 5篇 |
1967年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
AbstractWe have investigated communication preferences of mammography results in 90 patients through a structured interview approach. About 81% of patients expressed that they wanted to get the results, and 18% expressed that getting the results does not help if they are incomprehensible. In patients who want to get the results, 80% preferred face-to-face interaction with physicians, whereas the others preferred other modes of communication to prevent loss of time. Majority of patients infavor of face-to-face interaction (57%) preferred both the referring physician and the radiologist. Comprehensibility and fast delivery of reports, plus direct communication with radiologists are the requirements in mammography patients while implementing patient-centered radiology. 相似文献
4.
Very preterm children are at increased risk of reduced processing speed at 5 years of age,predicted by typical complications of prematurity and prenatal smoking 下载免费PDF全文
5.
6.
Jenny U. Johansson Nathaniel S. Woodling Qian Wang Maharshi Panchal Xibin Liang Angel Trueba-Saiz Holden D. Brown Siddhita D. Mhatre Taylor Loui Katrin I. Andreasson 《The Journal of clinical investigation》2015,125(1):350-364
Microglia, the innate immune cells of the CNS, perform critical inflammatory and noninflammatory functions that maintain normal neural function. For example, microglia clear misfolded proteins, elaborate trophic factors, and regulate and terminate toxic inflammation. In Alzheimer’s disease (AD), however, beneficial microglial functions become impaired, accelerating synaptic and neuronal loss. Better understanding of the molecular mechanisms that contribute to microglial dysfunction is an important objective for identifying potential strategies to delay progression to AD. The inflammatory cyclooxygenase/prostaglandin E2 (COX/PGE2) pathway has been implicated in preclinical AD development, both in human epidemiology studies and in transgenic rodent models of AD. Here, we evaluated murine models that recapitulate microglial responses to Aβ peptides and determined that microglia-specific deletion of the gene encoding the PGE2 receptor EP2 restores microglial chemotaxis and Aβ clearance, suppresses toxic inflammation, increases cytoprotective insulin-like growth factor 1 (IGF1) signaling, and prevents synaptic injury and memory deficits. Our findings indicate that EP2 signaling suppresses beneficial microglia functions that falter during AD development and suggest that inhibition of the COX/PGE2/EP2 immune pathway has potential as a strategy to restore healthy microglial function and prevent progression to AD. 相似文献
7.
Solyakov Lev Dobrota Dušan Drany Oleg Vachova Milena Machač Stanislav Mezešova Viera Bachurin Sergey Lombardi Vincenzo 《Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid》1995,25(2-3):123-134
Molecular and chemical neuropathology - Changes in the functioning of the glutamatergic system in rabbit brain were studied after partial brain ischemia and reperfusion. In vitro studies were... 相似文献
8.
Stoma Adjustable Silicone Gastric Banding versus Vertical Banded Gastroplasty for the Treatment of Morbid Obesity 总被引:1,自引:0,他引:1
Background: Among gastric restrictive operations, the procedure of choice is still controversial. The aim of this study is
to compare the results of two different gastric restrictive procedures: vertical banded gastroplasty (VBG) and stoma adjustable
silicone gastric banding (ASGB). Methods: Between 1991 and 1996, 51 patients were treated surgically for morbid obesity: 27
underwent VBG and 24 underwent ASGB. Preoperative body weight (BW), body mass index (BMI) and percentage of ideal body weight
(% IBW) were (mean ± SD): 145.7 ± 45.3 kg; 53.9 ± 15.9 kg/m2; 249.1 ± 73.5% respectively in the VBG group. Corresponding figures for the ASBG group were 132.5 ± 22.7 kg; 46.9 ± 7.8 kg/m2 and 207.2 ± 35.0%. Results: In the VBG group, the median follow-up period was 26 months (range: 7-47). Eighteen months after
the operation BW, BMI, % IBW and percentage of excess weight loss (% EWL) were 85.5 ± 26.8 kg, 31.9 ± 9.8 kg/m2, 145.4 ± 43.9% and 74 ± 1% respectively. Complications included incisional hernia (n = 1), and bowel obstruction (n = 1).
One patient died of acute myocardial infarction on the third postoperative day. In the ASGB group, median follow-up time was
19.7 months (range: 18-26). At 18 months postoperation BW, BMI, % IBW and % EWL values were 86.6 ± 20.6 kg 30.6 ± 6.6 kg/m2
140.6 ± 29.3% and 64 ± 1% respectively. Gastric wall erosion occurred in two patients and the bands had to be removed. These
patients underwent VBG 6 months later. Complications encountered in this group were incisional hernia (n = 1), outlet stenosis
and reflux esophagitis (n = 1), reservoir leakage (n = 1) and gastrointestinal bleeding (n = 1). Two patients died of pulmonary
embolism and acute gastrointestinal bleeding. Conclusions: Weight reduction was not statistically significant between the
two groups. ASGB was easier to perform and less invasive than VBG. 相似文献
9.
体外培养中IFN-γ、L-Arg 及L-NNA对NO合成的影响及NO抗旋毛虫的作用 总被引:5,自引:1,他引:4
目的 探讨体外培养中IFN γ、L Arg及L NNA对NO合成的影响及NO抗旋毛虫的作用。 方法 分离、纯化长爪沙鼠腹腔巨噬细胞 ,置RPMI16 4 0培养液中培养。设IFN γ组、L Arg组、L NNA组和对照组 ,每个实验组又分 5个不同的浓度组。分别向含有巨噬细胞的培养瓶中加入不同浓度的IFN γ、L Arg及L NNA进行体外培养。培养 2 4h后 ,用硝酸还原酶法分别测定培养液中的NO含量。将旋毛虫幼虫分别加入上述培养体系中进行体外培养 ,观察旋毛虫幼虫的活动及损伤。结果 ①体外培养中 ,激活的巨噬细胞能产生NO ,IFN γ和L Arg能促进NO的合成 ,L NNA则能抑制NO的合成 ,这种促进或抑制NO合成的作用均具有剂量依赖性 ,剂量越高作用越明显。②加入旋毛虫幼虫后 ,在IFN γ和L Arg培养体系中 ,随着NO浓度的升高及作用时间的延长 ,对虫体的抑制及杀伤作用越来越明显 ,导致其活动度减弱 ,虫体破裂 ,最终死亡 ;在L NNA培养体系中 ,L NNA浓度越高 ,对虫体的影响越小。结论 ①体外培养中 ,通过激活的巨噬细胞 ,IFN γ和L Arg能促进NO的合成 ,给予L NNA则能抑制NO的合成。②NO对旋毛虫幼虫有抑制及杀伤作用 相似文献
10.
Serum digoxin-like factor was detected in infants of diabetic mothers who were insulin-dependent or diet controlled. No statistical difference was found between the serum digoxin-like factor levels of the infants of diabetic mothers and the controls. 相似文献