全文获取类型
收费全文 | 10331篇 |
免费 | 587篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 120篇 |
儿科学 | 445篇 |
妇产科学 | 215篇 |
基础医学 | 1463篇 |
口腔科学 | 244篇 |
临床医学 | 810篇 |
内科学 | 2194篇 |
皮肤病学 | 256篇 |
神经病学 | 1114篇 |
特种医学 | 198篇 |
外科学 | 829篇 |
综合类 | 150篇 |
一般理论 | 3篇 |
预防医学 | 792篇 |
眼科学 | 319篇 |
药学 | 997篇 |
中国医学 | 22篇 |
肿瘤学 | 791篇 |
出版年
2023年 | 65篇 |
2022年 | 226篇 |
2021年 | 400篇 |
2020年 | 235篇 |
2019年 | 249篇 |
2018年 | 333篇 |
2017年 | 219篇 |
2016年 | 304篇 |
2015年 | 310篇 |
2014年 | 362篇 |
2013年 | 516篇 |
2012年 | 777篇 |
2011年 | 764篇 |
2010年 | 405篇 |
2009年 | 344篇 |
2008年 | 568篇 |
2007年 | 601篇 |
2006年 | 591篇 |
2005年 | 532篇 |
2004年 | 540篇 |
2003年 | 480篇 |
2002年 | 444篇 |
2001年 | 99篇 |
2000年 | 109篇 |
1999年 | 115篇 |
1998年 | 75篇 |
1997年 | 70篇 |
1996年 | 61篇 |
1995年 | 35篇 |
1994年 | 40篇 |
1993年 | 41篇 |
1992年 | 78篇 |
1991年 | 95篇 |
1990年 | 47篇 |
1989年 | 85篇 |
1988年 | 66篇 |
1987年 | 66篇 |
1986年 | 67篇 |
1985年 | 44篇 |
1984年 | 34篇 |
1983年 | 30篇 |
1982年 | 29篇 |
1981年 | 23篇 |
1979年 | 37篇 |
1977年 | 31篇 |
1975年 | 23篇 |
1974年 | 45篇 |
1973年 | 37篇 |
1972年 | 29篇 |
1971年 | 25篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
Background
Traumatic perforation of the distal oesophagus due to blunt trauma is a very rare condition and is still associated with a significant morbidity and mortality. This is further exacerbated by delayed diagnosis and management as symptoms and signs are often masked by or ascribed to more common blunt thoracic injuries. 相似文献8.
Anneloes Dirks Lucianne Groenink Koen G C Westphal Jocelien D A Olivier P Monika Verdouw Jan van der Gugten Mark A Geyer Berend Olivier 《Neuropsychopharmacology》2003,28(10):1790-1798
Chronically elevated levels of corticotropin-releasing factor (CRF) in transgenic mice overexpressing CRF in the brain (CRF-OE) appear to be associated with alterations commonly associated with major depressive disorder, as well as with sensorimotor gating deficits commonly associated with schizophrenia. In the present study, we tested the hypothesis that antipsychotics may be effective in normalizing prepulse inhibition (PPI) of acoustic startle in CRF-OE mice, which display impaired sensorimotor gating compared to wild-type (WT) mice. The typical antipsychotic haloperidol and atypical antipsychotic risperidone improved PPI in the CRF-OE mice, but were ineffective in WT mice. The atypical antipsychotic clozapine did not influence PPI in CRF-OE mice, but reduced gating in WT mice. This effect of clozapine in the CRF-OE mice may thus be regarded as a relative improvement, consistent with the observed effect of haloperidol and risperidone. As expected, the anxiolytic, nonantipsychotic chlordiazepoxide was devoid of any effect. All four compounds dose-dependently reduced the acoustic startle response irrespective of genotype. These results indicate that antipsychotic drugs are effective in improving startle gating deficits in the CRF-OE mice. Hence, the CRF-OE mouse model may represent an animal model for certain aspects of psychotic depression, and could be a valuable tool for research addressing the impact of chronically elevated levels of CRF on information processing. 相似文献
9.
10.
Y K Murali P Anand V Tandon R Singh R Chandra P S Murthy 《Experimental and clinical endocrinology & diabetes》2007,115(10):641-646
The aqueous extract of the fruits of Terminalia chebula Retz. has been evaluated for its antidiabetic activity in streptozotocin (STZ) induced mild diabetic rats and compared with a known drug, tolbutamide. The oral effective dose (ED) of the extract was observed to be 200 mg/kg body weight, which produced a fall of 55.6% (p<0.01) in the oral glucose tolerance test. Oral administration of ED of aqueous extract of T.chebula (AETC) daily once for two months reduced the elevated blood glucose by 43.2% (p<0.01) and significantly reduced the increase in glycosylated hemoglobin (HbA1c) (p<0.01). The same dose also showed a marked improvement in controlling the elevated blood lipids as well as decreased serum insulin levels in contrast to the untreated diabetic animals. Hepatic and skeletal muscle glycogen content decreased by 75% and 62.9% respectively in diabetic controls, these alterations were partly prevented (34.9% and 21.17%) in AETC treated group when compared to the healthy controls. The in vitro studies with pancreatic islets showed that the insulin release was nearly two times more than that in untreated diabetic animals. The treatment did not have any unfavorable effect on other blood parameters of liver and kidney function tests. LD 50 was found to be above 3 g/kg bw i.e. 15 times of ED, because there were no deaths of animals even at this dose indicating high margin of safety. These findings suggest further investigations for the possible use of the aqueous extract of fruits of T.chebula for the treatment of diabetes. 相似文献