全文获取类型
收费全文 | 1823327篇 |
免费 | 139774篇 |
国内免费 | 12871篇 |
专业分类
耳鼻咽喉 | 22731篇 |
儿科学 | 57458篇 |
妇产科学 | 47529篇 |
基础医学 | 253238篇 |
口腔科学 | 51257篇 |
临床医学 | 169803篇 |
内科学 | 348981篇 |
皮肤病学 | 40224篇 |
神经病学 | 135672篇 |
特种医学 | 68393篇 |
外国民族医学 | 286篇 |
外科学 | 267231篇 |
综合类 | 68075篇 |
现状与发展 | 44篇 |
一般理论 | 538篇 |
预防医学 | 136838篇 |
眼科学 | 43805篇 |
药学 | 138804篇 |
240篇 | |
中国医学 | 15193篇 |
肿瘤学 | 109632篇 |
出版年
2021年 | 19225篇 |
2020年 | 13362篇 |
2019年 | 17439篇 |
2018年 | 23931篇 |
2017年 | 19681篇 |
2016年 | 20341篇 |
2015年 | 25185篇 |
2014年 | 33857篇 |
2013年 | 45787篇 |
2012年 | 64427篇 |
2011年 | 67797篇 |
2010年 | 42342篇 |
2009年 | 38632篇 |
2008年 | 60181篇 |
2007年 | 63170篇 |
2006年 | 62636篇 |
2005年 | 59067篇 |
2004年 | 55068篇 |
2003年 | 52169篇 |
2002年 | 49625篇 |
2001年 | 94267篇 |
2000年 | 95661篇 |
1999年 | 78524篇 |
1998年 | 20655篇 |
1997年 | 18232篇 |
1996年 | 18120篇 |
1995年 | 17360篇 |
1994年 | 15861篇 |
1993年 | 14404篇 |
1992年 | 57673篇 |
1991年 | 55532篇 |
1990年 | 53205篇 |
1989年 | 50932篇 |
1988年 | 46303篇 |
1987年 | 45086篇 |
1986年 | 42317篇 |
1985年 | 40053篇 |
1984年 | 29387篇 |
1983年 | 24941篇 |
1982年 | 13912篇 |
1979年 | 25537篇 |
1978年 | 17575篇 |
1977年 | 14906篇 |
1976年 | 13875篇 |
1975年 | 14566篇 |
1974年 | 17632篇 |
1973年 | 16948篇 |
1972年 | 15673篇 |
1971年 | 14453篇 |
1970年 | 13431篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Molnár B. Aroca S. Dobos A. Orbán K. Szabó J. Windisch P. Stähli A. Sculean A. 《Clinical oral investigations》2022,26(12):7135-7142
Clinical Oral Investigations - To evaluate t he long-term outcomes following treatment of RT 1 multiple adjacent gingival recessions (MAGR) using the modified coronally advanced tunnel (MCAT) with... 相似文献
2.
3.
Kienbaum Peter Schaefer Maximilian S. Weibel Stephanie Schlesinger Tobias Meybohm Patrick Eberhart Leopold H. Kranke Peter 《Der Anaesthesist》2022,71(2):123-128
Die Anaesthesiologie - Auch wenn für Anästhesiologen über Jahrzehnte die Prophylaxe und Therapie postoperativer Schmerzen im Rahmen des postoperativen Patientenkomforts an vorderster... 相似文献
4.
5.
6.
目的 探究高密度多孔聚乙烯植入体在鼻整形中的应用价值方法 选取2019年5月-2021年8月我院接受综合鼻整形手术的106例患者为研究对象,采用照随机数字表法分为对照组和观察组,各53例。 对照组采用自体肋骨植入术,观察组采用高密度多孔聚乙烯植入体植入治疗,比较两组临床手术指标(手术时间、恢复时间)、整形优良率、鼻指标(鼻高度/鼻长度比例、鼻唇角)、并发症发生率以及疼痛评分结果 观察组手术时间、术后恢复时间均短于对照组(P<0.05);观察组整形优良率为94.34%,高于对照组的86.79%,差异有统计学意义(P<0.05);观察组鼻高度/鼻长度比例高于对照组,鼻唇角小于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为5.66%,低于对照组的15.09%,差异有统计学意义(P<0.05);观察组疼痛评分低于对照组,差异有统计学意义(P<0.05);观察组治疗满意度为 96.23%,高于对照组的84.91%,差异有统计学意义(P<0.05)结论 高密度多孔聚乙烯植入体在鼻整形中的应用效果理想,可减轻患者疼痛度,缩短手术和恢复时间,降低并发症发生率,改善鼻高度/鼻长度比例和鼻唇角,实现理想的整形效果。 相似文献
7.
Wuteng Cao Huabin Hu Jiao Li Qianyu Wu Lishuo Shi Biao Li Jie Zhou Xinhua Wang Junhong Chen Chao Wang Huaiming Wang Weihao Deng Yan Huang Yanhong Deng 《International journal of cancer. Journal international du cancer》2023,153(11):1894-1903
Neoadjuvant programmed cell death protein 1 (PD-1) blockade exhibits promising efficacy in patients with mismatch repair deficient (dMMR) colorectal cancer (CRC). However, discrepancies between radiological and histological findings have been reported in the PICC phase II trial (NCT 03926338). Therefore, we strived to discern radiological features associated with pathological complete response (pCR) based on computed tomography (CT) images. Data were obtained from the PICC trial that included 36 tumors from 34 locally advanced dMMR CRC patients, who received neoadjuvant PD-1 blockade for 3 months. Among the 36 tumors, 28 (77.8%) tumors achieved pCR. There were no statistically significant differences in tumor longitudinal diameter, the percentage change in tumor longitudinal diameter from baseline, primary tumor sidedness, clinical stage, extramural venous invasion status, intratumoral calcification, peritumoral fat infiltration, intestinal fistula and tumor necrosis between the pCR and non-pCR tumors. Otherwise, tumors with pCR had smaller posttreatment tumor maximum thickness (median: 10 mm vs 13 mm, P = .004) and higher percentage decrease in tumor maximum thickness from baseline (52.9% vs 21.6%, P = .005) compared to non-pCR tumors. Additionally, a higher proportion of the absence of vascular sign (P = .003, odds ratio [OR] = 25.870 [95% CI, 1.357-493.110]), nodular sign (P < .001, OR = 189.000 [95% CI, 10.464-3413.803]) and extramural enhancement sign (P = .003, OR = 21.667 [2.848-164.830]) was observed in tumors with pCR. In conclusion, these CT-defined radiological features may have the potential to serve as valuable tools for clinicians in identifying patients who have achieved pCR after neoadjuvant PD-1 blockade, particularly in individuals who are willing to adopt a watch-and-wait strategy. 相似文献
8.
9.
10.
Karl Johnson Katherine W. Saylor Isabella Guynn Karen Hicklin Jonathan S. Berg Kristen Hassmiller Lich 《Genetics in medicine》2022,24(2):262-288
PurposeUnderstanding the value of genetic screening and testing for monogenic disorders requires high-quality, methodologically robust economic evaluations. This systematic review sought to assess the methodological quality among such studies and examined opportunities for improvement.MethodsWe searched PubMed, Cochrane, Embase, and Web of Science for economic evaluations of genetic screening/testing (2013-2019). Methodological rigor and adherence to best practices were systematically assessed using the British Medical Journal checklist.ResultsAcross the 47 identified studies, there were substantial variations in modeling approaches, reporting detail, and sophistication. Models ranged from simple decision trees to individual-level microsimulations that compared between 2 and >20 alternative interventions. Many studies failed to report sufficient detail to enable replication or did not justify modeling assumptions, especially for costing methods and utility values. Meta-analyses, systematic reviews, or calibration were rarely used to derive parameter estimates. Nearly all studies conducted some sensitivity analysis, and more sophisticated studies implemented probabilistic sensitivity/uncertainty analysis, threshold analysis, and value of information analysis.ConclusionWe describe a heterogeneous body of work and present recommendations and exemplar studies across the methodological domains of (1) perspective, scope, and parameter selection; (2) use of uncertainty/sensitivity analyses; and (3) reporting transparency for improvement in the economic evaluation of genetic screening/testing. 相似文献