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Éktova L. V. Goryunova O. V. Eremina V. A. Tikhonova N. I. Medvedeva L. A. 《Pharmaceutical Chemistry Journal》2019,53(7):604-609
Pharmaceutical Chemistry Journal - Use of formylindolylacetic acid as a reagent at the stage of preparing the glycosides of bis(indolyl)furan-2,5-diones and dioxane as solvent increased yields from... 相似文献
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T E Medvedeva V K Kudriavtseva I V Zhikhareva V V Romashkina G I Aleksandrova A I Klimov 《Voprosy virusologii》1991,36(2):96-100
An analysis of ts-mutations in the genomes of native and cold-adapted variants of influenza A/Leningrad/134/57 (H2N2) virus based on the use of fowl plague virus ts mutants was carried out. The recombination test was done by the conventional method in chick embryo fibroblast culture (genes PB2, PB1, PA, NP, NA, M and NS) or cell systems permissive for reproduction of human influenza virus (gene HA). The cold-adapted strain A/Len/17 used for preparation of live influenza vaccine (LIV) for adults was shown to have 4 ts mutations: three in "internal" genes (PB2, NP, and M) and one in gene 4 coding for hemagglutinin (HA). The more attenuated cold-adapted donor A/Len/47 for preparation of similar LIV for children acquired three additional ts mutations: two (PB1 and NS) in "internal" genes and one in gene 6 coding for neuraminidase (NA). The accumulation of ts mutations in the genome of cold-adapter strains was found to be accompanied by a decrease in their pneumotropicity for mice as well as their detectability in different organs of these animals. 相似文献
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Recombinant cold-adapted attenuated influenza A vaccines for use in children: molecular genetic analysis of the cold-adapted donor and recombinants
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Y Z Ghendon F I Polezhaev K V Lisovskaya T E Medvedeva G I Alexandrova A I Klimov 《Infection and immunity》1984,44(3):730-733
A previously described cold-adapted attenuated virus, A/Leningrad/134/17/57 (H2N2), was further modified by 30 additional passages in chicken embryos at 25 degrees C. This virus had a distinct temperature-sensitive (ts) phenotype, grew well in chicken embryos at 25 degrees C, and failed to recombine with reference ts mutants of fowl plague virus containing ts lesions in five genes coding for non-glycosylated proteins (genes 1, 2, 5, 7, and 8). Recombination of A/Leningrad/134/47/57 with wild-type influenza virus strains A/Leningrad/322/79 (H1N1) and A/Bangkok/1/79(H3N2) yielded ts recombinants 47/25/1(H1N1) and 47/7/2 (H3N2). These recombinants inherited their ts phenotype and ability to reproduce in chicken embryos at 25 degrees C from the cold-adapted parent. Analysis of the genome composition of the recombinants obtained by recombination of the cold-adapted donor with wild-type influenza virus strains A/Leningrad/322/79(H1N1) and A/Bangkok/1/79(H3N2) showed that recombinants 47/25/1(H1N1) and 47/7/2 (H3N2) inherited five and six genes, respectively, from the cold-adapted parent, and hemagglutinin and neuraminidase genes from the wild-type strains. 相似文献
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A comparative analysis of the antihaemagglutinating, virus-neutralizing and complement-fixing activities of 19 S, 7 S, 4S and 1.5 S fractions of blood sera from goats of different ages pastured in a tick-borne encephalitis focus was carried out. Changes in the immunological activity of different fractions in relation to the age of the animals are discussed. 相似文献
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Neuroprotective effect of epinephrine is revealed against the background of prazosin, β-antagonists and their combinations
protect against cerebral ischemia. α2-Antagonists (but not α1) block the neuroprotective effect of these combinations, methyldopa, guanabenz, clonidine, and oxymetazoline and decrease
brain resistance to ischemia. α2-Adrenoreceptors participate in the endogenic mechanism of brain resistance to ischemia and in the neuroprotective effect.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 10, pp. 413–416, October, 1997 相似文献
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