全文获取类型
收费全文 | 195278篇 |
免费 | 18234篇 |
国内免费 | 11384篇 |
专业分类
耳鼻咽喉 | 1871篇 |
儿科学 | 2460篇 |
妇产科学 | 2159篇 |
基础医学 | 28361篇 |
口腔科学 | 3522篇 |
临床医学 | 23405篇 |
内科学 | 28549篇 |
皮肤病学 | 2334篇 |
神经病学 | 10054篇 |
特种医学 | 7503篇 |
外国民族医学 | 85篇 |
外科学 | 19402篇 |
综合类 | 29282篇 |
现状与发展 | 38篇 |
一般理论 | 17篇 |
预防医学 | 13139篇 |
眼科学 | 4687篇 |
药学 | 21797篇 |
159篇 | |
中国医学 | 10124篇 |
肿瘤学 | 15948篇 |
出版年
2024年 | 732篇 |
2023年 | 3008篇 |
2022年 | 7695篇 |
2021年 | 10044篇 |
2020年 | 7284篇 |
2019年 | 6494篇 |
2018年 | 6825篇 |
2017年 | 6203篇 |
2016年 | 6003篇 |
2015年 | 8728篇 |
2014年 | 10634篇 |
2013年 | 10359篇 |
2012年 | 14594篇 |
2011年 | 15449篇 |
2010年 | 10537篇 |
2009年 | 8463篇 |
2008年 | 10490篇 |
2007年 | 10409篇 |
2006年 | 9561篇 |
2005年 | 8762篇 |
2004年 | 6751篇 |
2003年 | 6451篇 |
2002年 | 5491篇 |
2001年 | 4521篇 |
2000年 | 4033篇 |
1999年 | 3719篇 |
1998年 | 2267篇 |
1997年 | 2351篇 |
1996年 | 1696篇 |
1995年 | 1599篇 |
1994年 | 1452篇 |
1993年 | 976篇 |
1992年 | 1331篇 |
1991年 | 1164篇 |
1990年 | 1057篇 |
1989年 | 958篇 |
1988年 | 863篇 |
1987年 | 744篇 |
1986年 | 685篇 |
1985年 | 541篇 |
1984年 | 449篇 |
1983年 | 369篇 |
1982年 | 294篇 |
1981年 | 262篇 |
1980年 | 218篇 |
1979年 | 235篇 |
1978年 | 213篇 |
1977年 | 233篇 |
1976年 | 223篇 |
1974年 | 181篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
European Archives of Oto-Rhino-Laryngology - Several polymorphisms in a disintegrin and metalloproteinase 33 (ADAM33) have been implicated in susceptibility to allergic rhinitis (AR), but the... 相似文献
2.
3.
4.
5.
Marlene L Hauck Susan M LaRue William P Petros Jean M Poulson Daohai Yu Ivan Spasojevic Amy F Pruitt Allison Klein Beth Case Donald E Thrall David Needham Mark W Dewhirst 《Clinical cancer research》2006,12(13):4004-4010
PURPOSE: To determine the maximum tolerated dose, dose-limiting toxicities, and pharmacokinetic characteristics of doxorubicin encapsulated in a low temperature sensitive liposome (LTSL) when given concurrently with local hyperthermia to canine solid tumors. EXPERIMENTAL DESIGN: Privately owned dogs with solid tumors (carcinomas or sarcomas) were treated. The tumors did not involve bone and were located at sites amenable to local hyperthermia. LTSL-doxorubicin was given (0.7-1.0 mg/kg i.v.) over 30 minutes during local tumor hyperthermia in a standard phase I dose escalation study. Three treatments, given 3 weeks apart, were scheduled. Toxicity was monitored for an additional month. Pharmacokinetics were evaluated during the first treatment cycle. RESULTS: Twenty-one patients were enrolled: 18 with sarcomas and 3 with carcinomas. Grade 4 neutropenia and acute death secondary to liver failure, possibly drug related, were the dose-limiting toxicities. The maximum tolerated dose was 0.93 mg/kg. Other toxicities, with the possible exception of renal damage, were consistent with those observed following free doxorubicin administration. Of the 20 dogs that received > or = 2 doses of LTSL-doxorubicin, 12 had stable disease, and 6 had a partial response to treatment. Pharmacokinetic variables were more similar to those of free doxorubicin than the marketed liposomal product. Tumor drug concentrations at a dose of 1.0 mg/kg averaged 9.12 +/- 6.17 ng/mg tissue. CONCLUSION: LTSL-doxorubicin offers a novel approach to improving drug delivery to solid tumors. It was well tolerated and resulted in favorable response profiles in these patients. Additional evaluation in human patients is warranted. 相似文献
6.
H J Kim C H Kang Y T Kim S-W Sung J H Kim S M Lee C-G Yoo C-T Lee Y W Kim S K Han Y-S Shim J-J Yim 《The European respiratory journal》2006,28(3):576-580
Although surgical lung resection could improve prognosis in some patients with multidrug-resistant tuberculosis (MDR-TB), there are no reports on the optimal candidates for this surgery. The aim of the present study was to elucidate the prognostic factors for surgery in patients with MDR-TB. Patients who underwent lung resection for the treatment of MDR-TB between March 1993 and December 2004 were included in the present study. Treatment failure was defined as greater than or equal to two of the five cultures recorded in the final 12 months of treatment being positive, any one of the final three cultures being positive, or the patient having died during treatment. The variables that affected treatment outcomes were identified through univariate and multivariate logistic regression analysis. In total, 79 patients with MDR-TB were included in the present study. The treatment outcomes of 22 (27.8%) patients were classified as failure. A body mass index <18.5 kg x m(-2), primary resistance, resistance to ofloxacin and the presence of a cavitary lesion beyond the range of the surgical resection were associated with treatment failure. Low body mass index, primary resistance, resistance to ofloxacin and cavitary lesions beyond the range of resection are possible poor prognostic factors for surgical lung resection in multidrug-resistant tuberculosis patients. 相似文献
7.
A new semi-empirical formula for the evaluation of (n,(3)He) reaction cross-sections at the energy of 14.6 and 20 MeV is presented. Formula was derived using the analytical expression for the evaluation of the (3)He spectrum within the frame of pre-equilibrium exciton model. The systematics obtained is compared with the empirical formula for the (n,(3)He) reaction cross-section. 相似文献
8.
逍遥散出自《太平惠民和剂局方》,由当归、白芍药、柴胡、茯苓、白术、炙甘草、薄荷、煨姜组成。经前期综合征为临床常见的妇科病症,笔者近年来采用逍遥散加减治疗经前期综合征69例,疗效满意,现报道如下。 相似文献
9.
AIMS: To establish all-cause and cause-specific death rates, and risk factors for mortality in insulin-treated diabetic individuals living in the province of Canterbury, New Zealand. METHODS: Insulin-treated diabetic subjects (n = 995) on the Canterbury Diabetes Registry were followed up over 15 years and vital status determined. Death rates were standardized and hazard regression was used to model the effects of demographic covariates on relative survival time. RESULTS: There were 419 deaths in 11 226.3 person-years of follow-up with a standardized mortality ratio (SMR) of 2.0 (95% confidence interval (CI) 1.8-2.2). Relative mortality was greatest for the group aged 0-29 years (SMR 3.0 (95% CI 2.4-3.7)). After controlling for diabetes duration and gender, a 10-year increment in age of onset was associated with a 33% decrease in relative hazard (95% CI 29-36%), indicating that excess mortality due to diabetes declines with rising age of onset. After controlling for age of onset and gender, each 10-year increment in duration of diabetes is associated with a 26% decrease in relative hazard (95% CI 24-29%), indicating that with longer survival the mortality hazard approaches the general population hazard. Relative mortalities were increased for cardiovascular, renal and respiratory disease, but not malignancy. Relative mortality from acute metabolic complications was increased in the subgroup with age of onset of diabetes < 30 years and requiring insulin within 1 year of diagnosis. CONCLUSIONS: Mortality rates are high for insulin-treated diabetic individuals relative to the general population. 相似文献
10.