全文获取类型
收费全文 | 2338篇 |
免费 | 124篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 58篇 |
妇产科学 | 15篇 |
基础医学 | 262篇 |
口腔科学 | 66篇 |
临床医学 | 205篇 |
内科学 | 528篇 |
皮肤病学 | 84篇 |
神经病学 | 95篇 |
特种医学 | 58篇 |
外科学 | 414篇 |
综合类 | 16篇 |
预防医学 | 183篇 |
眼科学 | 15篇 |
药学 | 224篇 |
中国医学 | 2篇 |
肿瘤学 | 244篇 |
出版年
2023年 | 12篇 |
2022年 | 35篇 |
2021年 | 42篇 |
2020年 | 26篇 |
2019年 | 46篇 |
2018年 | 61篇 |
2017年 | 44篇 |
2016年 | 43篇 |
2015年 | 54篇 |
2014年 | 68篇 |
2013年 | 70篇 |
2012年 | 127篇 |
2011年 | 117篇 |
2010年 | 57篇 |
2009年 | 58篇 |
2008年 | 67篇 |
2007年 | 94篇 |
2006年 | 85篇 |
2005年 | 77篇 |
2004年 | 78篇 |
2003年 | 85篇 |
2002年 | 107篇 |
2001年 | 89篇 |
2000年 | 67篇 |
1999年 | 67篇 |
1998年 | 24篇 |
1997年 | 14篇 |
1996年 | 14篇 |
1995年 | 14篇 |
1994年 | 15篇 |
1992年 | 57篇 |
1991年 | 31篇 |
1990年 | 56篇 |
1989年 | 50篇 |
1988年 | 47篇 |
1987年 | 58篇 |
1986年 | 68篇 |
1985年 | 52篇 |
1984年 | 30篇 |
1983年 | 33篇 |
1982年 | 14篇 |
1979年 | 22篇 |
1977年 | 13篇 |
1976年 | 14篇 |
1974年 | 15篇 |
1971年 | 20篇 |
1969年 | 14篇 |
1968年 | 11篇 |
1967年 | 13篇 |
1966年 | 12篇 |
排序方式: 共有2475条查询结果,搜索用时 15 毫秒
1.
Tayama K; Takamori S; Mitsuoka M; Hiraki H; Ohtsuka S; Hayashi A; Aoyama Y; Shirouzu K 《Japanese journal of clinical oncology》1997,27(6):401-405
The aim of this study was to investigate retrospectively the efficacy of
expandable metallic stents (EMSs) for severe respiratory distress in
patients with central airway obstruction. Twenty patients with central
airway obstructions were treated with an EMS. An intraluminal stricture was
present in 15 and an extraluminal stricture in 5 patients. Of the 15
patients with intraluminal stenosis, 11 exhibited symptomatic improvement.
All 11 patients had tumor infiltration occupying less than 50% of the
endoluminal diameter. The other four patients with intraluminal stenosis
had tumor infiltration occupying > 50% of the endoluminal diameter and
demonstrated no improvement. All five patients with extraluminal stenosis
were improved. EMS is useful for an extraluminal stricture in the central
airway and the effect of EMS for intraluminal stenosis is related to the
degree of infiltration and of tumor progression itself.
相似文献
2.
Fumio Aoyama 《Anatomy and embryology》1930,93(1-2):107-181
Ohne ZusammenfassungMit 26 Textabbildungen. 相似文献
3.
4.
Aoyama Takao Yamamoto Koujirou Kotaki Hajime Sawada Yasufumi Iga Tatsuji 《Pharmaceutical research》1997,14(11):1601-1606
Purpose. The locomotive activity changes after intravenous (i.v.) administration of methylphenidate (MPD) in rats were pharmacodynamically analyzed.
Methods. MPD concentration in plasma, MPD concentration and dopamine (DA) level in striatal dialysate collected by microdialysis method, and the locomotor activity after i.v. administration of MPD (2, 5 and 10 mg/kg doses) were used for the analysis.
Results. The transport of MPD from plasma to the interstitial fluid in the brain could be expressed by the linear two-compartment model. The clockwise hysteresis between the MPD concentration and the DA level in the dialysate could be explained by the pharmacodynamic model considering Michaelis-Menten type reuptake process of the extracellular DA into the terminal of the dopaminergic nerve and its competitive inhibition by the extracellular MPD. The inhibition constant (Ki) of MPD for DA reuptake was estimated to be 41.3 ± 73.8 nM (mean ± SE), which was closely consistent with the in vitro value after correction with dialysis recovery. The relationship between DA level in dialysate and locomotor activity was expressed by the Emax model considering two contrary effects, hyperkinesia and stereotypy. The bi-phasic locomotor activity-time profiles after high dose of MPD could be represented by this model.
Conclusions. The developed model made it possible to explain the tolerance in DA increase and the complicated locomotive change induced by MPD, and may be useful for other DA reuptake inhibitors, such as amphetamine and methamphetamine. 相似文献
5.
A Ueda K Aoyama T Ueda K Obama T Ueno S Hokama S Nomura 《British journal of industrial medicine》1992,49(7):499-506
The only workers presently exposed to bagasse dust in Japan are the employees of sugar refineries and lacquerware factories. A follow up study of six former cases of bagassosis from among the retired employees of a paper board factory, closed since 1973, showed that none of the subjects still had bagassosis. Examinations of 70 employees of a sugar refinery for allergic reactions also showed no case of bagassosis. Seven cases with suspicious shadows of bagassosis on chest radiographs and four cases with positive serum precipitin to stored bagasse were, however, found among those 70 subjects. The results show the disappearance of a past episode of bagassosis and the possibility of a new occurrence of bagassosis among the employees of sugar refineries and lacquerware factories in the near future in Japan. 相似文献
6.
Yukako Sato Masahiko Aoyama Tomoko Soeda Akihiko Hoshi Mari Honma Teiji Yamamoto 《Clinical neurology》2004,44(8):527-530
A 65-year-old woman with diabetes mellitus and chronic otitis media developed headache, fever, and hoarseness, all of which did not responded to the oral antibiotics. As stiff neck and lower cranial nerve palsies appeared, bacterial meningitis was suspected. Neurological examination revealed the right hearing disturbance, right recurrent laryngeal nerve palsy, left sternocleidomastoid muscle atrophy and bilateral tongue atrophy. The CSF examination revealed mild pleocytosis and elevated protein, but no bacterial organism was cultured from the CSF. CT scans showed bilateral mastoiditis, and the right mastoid process and a posterior part of the petrous bone were eroded, indicating the exposed bony structures to the posterior fossa. MRI scans demonstrated the thickening of the dura mater of the posterior fossa and the right cerebellar tentorium. This is a rare example of bacterial pachymeningitis of the posterior fossa, the clinical symptoms and MRI findings of which resolved solely by antimicrobial agents without corticosteroid. 相似文献
7.
8.
Y Aoyama K Ishida K Hori A Sakaguchi M Kudoh Y Yoshida 《Biochemical pharmacology》1992,44(9):1701-1705
AFK-108 (1-[2-(2,4-dichlorophenyl)-2-((2E)-3,7-dimethylocta-2,6- dienyloxy)ethyl]-1H-imidazole) is a new imidazole derivative characterized by a geranyl substituent showing strong antifungal activity. Azole antifungal agents are known to be potent inhibitors of lanosterol 14 alpha-demethylase (P450(14)DM) of fungi. The role of the geranyl group of AFK-108 on interaction of AFK-108 with the target was studied by using Saccharomyces cerevisiae P450(14)DM as the model enzyme. AFK-108 and some of its derivatives bound to oxidized P450(14)DM with one-to-one stoichiometry and inhibited the demethylase activity. AFK-108 derivatives having the longer farnesyl or the shorter prenyl group showed lower affinity than AFK-108 for the enzyme. AFK-108 caused 100% inhibition at the equivalent concentration to P450(14)DM in the reaction mixture (0.07 microM), while the farnesyl derivative inhibited the activity by 60% at the same concentration. AFK-108 interfered with the binding of CO to the ferrous P450(14)DM. However, the interfering effect of the prenyl derivative was lower than that of AFK-108. Another AFK-108 derivative having the saturated 3,7-dimethyloctyl group was also a weaker inhibitor than AFK-108. These experiments suggest that the geranyl group of AFK-108 interacts with the substrate binding site of P450(14)DM that recognises the side chain of the substrate. AFK-108 is the first example of an azole derivative interacting with the side chain recognising region of the substrate binding site of P450(14)DM. 相似文献
9.
10.
Mitochondrial trifunctional protein deficiency. Catalytic heterogeneity of the mutant enzyme in two patients. 总被引:7,自引:4,他引:3 下载免费PDF全文
T Kamijo R J Wanders J M Saudubray T Aoyama A Komiyama T Hashimoto 《The Journal of clinical investigation》1994,93(4):1740-1747
We examined the enzyme protein and biosynthesis of human trifunctional protein harboring enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase activity in cultured skin fibroblasts from two patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. The following results were obtained. (a) In cells from patient 1, immunoblot analysis and pulse-chase experiments indicated that the content of trifunctional protein was < 10% of that in control cells, due to a very rapid degradation of protein newly synthesized in the mitochondria. The diminution of trifunctional protein was associated with a decreased activity of enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase, when measured using medium-chain to long-chain substrates. (b) In cells from patient 2, the rate of degradation of newly synthesized trifunctional protein was faster than that in control cells, giving rise to a trifunctional protein amounting to 60% of the control levels. The 3-hydroxy-acyl-CoA dehydrogenase activity with medium-chain to long-chain substrates was decreased drastically, with minor changes in activities of the two other enzymes. These data suggest a subtle abnormality of trifunctional protein in cells from patient 2. Taken together, the results obtained show that in both patients, long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency is caused by an abnormality in the trifunctional protein, even though there is a heterogeneity in both patients. 相似文献