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排序方式: 共有188条查询结果,搜索用时 0 毫秒
1.
ALBERTO Q FARIAS LUCIANA L GONÇALVES EDUARDO LR CANÇADO ANTONIO C SEGURO SILVIA B CAMPOS CLARICE P ABRANTES-LEMOS FLAIR J CARRILHO 《Journal of gastroenterology and hepatology》2006,20(1):147-152
Background and Aims: Primary biliary cirrhosis (PBC) might be complicated by osteoporosis, whose etiology remains unknown but seems to be multifactorial. Prevalence rates of 30% to 60% for distal renal tubular acidosis (DRTA) have been reported in PBC patients, generally as incomplete DRTA. Although it is undisputed that a reduced bone mineral density (BMD) is the expected outcome among patients who have been suffering from longstanding chronic metabolic acidosis, it is unclear if incomplete DRTA is also associated with metabolic bone disease in PBC patients. The present study was undertaken to compare the BMD of PBC patients with and without DRTA.
Methods: The BMD of 23 PBC patients (11 with DRTA and 12 without), all with normal clearance of creatinine, was assessed by dual energy radiograph absorptiometry. The diagnosis of DRTA was made if the urine pH was above 5.4 in all samples after the oral acid overload, showing tubular inability to acidify urine in the presence of test-induced systemic metabolic acidosis.
Results: Densitometric signs of osteoporosis were found in 82% of DRTA cases and in 83% of patients without DRTA (difference not significant). There were no significant differences in BMD measurement, T and Z scores of patients with and without DRTA.
Conclusions: The present study could not support a correlation between the presence of DRTA and the bone loss observed in PBC patients. 相似文献
Methods: The BMD of 23 PBC patients (11 with DRTA and 12 without), all with normal clearance of creatinine, was assessed by dual energy radiograph absorptiometry. The diagnosis of DRTA was made if the urine pH was above 5.4 in all samples after the oral acid overload, showing tubular inability to acidify urine in the presence of test-induced systemic metabolic acidosis.
Results: Densitometric signs of osteoporosis were found in 82% of DRTA cases and in 83% of patients without DRTA (difference not significant). There were no significant differences in BMD measurement, T and Z scores of patients with and without DRTA.
Conclusions: The present study could not support a correlation between the presence of DRTA and the bone loss observed in PBC patients. 相似文献
2.
ALCOHOL DEHYDROGENASE FROM HUMAN STOMACH: VARIABILITY IN NORMAL MUCOSA AND EFFECT OF AGE, GENDER, ADH3 PHENOTYPE AND GASTRIC REGION 总被引:5,自引:1,他引:4
MORENO ALBERTO; PARES ALBERT; ORTIZ JORDI; ENRIQUEZ JAIME; PARES XAVIER 《Alcohol and alcoholism (Oxford, Oxfordshire)》1994,29(6):663-671
Alcohol dehydrogenase (ADH) has been analysed in 36 endoscopicbiopsies of normal gastric body and/or antrum mucosa, from 31individuals with an age between 17 and 79 years. Oesophageal,duodenal and oral mucosa specimens have been also examined.Stomach mucosa contains three isozyme types: the 相似文献
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Clinical Usefulness of a Mobile Application for the Appropriate Selection of the Antiarrhythmic Device in Heart Failure
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7.
Long‐Term Outcome of Patients with Bifascicular Block and Unexplained Syncope Following Cardiac Pacing
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MATTHEW M. KALSCHEUR M.D. PAOLO DONATEO M.D. KEVIN E. WENZKE M.D. MILENA ASTE M.D. DANIELE ODDONE M.D. ALBERTO SOLANO M.D. ROBERTO MAGGI M.D. FRANCESCO CROCI M.D. RICHARD L. PAGE M.D. MICHELE BRIGNOLE M.D. MOHAMED H. HAMDAN M.D. M.B.A. 《Pacing and clinical electrophysiology : PACE》2016,39(10):1126-1131
8.
FRANCESCO CHILLEMI SILVANA CAPPELLETTI PIERANGELO FRANCESCATO ALBERTO CHERSI 《Chemical biology & drug design》1990,35(3):271-280
Six peptides with amino acid sequences of human histocompatibility Class II membrane glycoproteins were synthesized by conventional solution methods. Five peptides were prepared by stepwise procedures from the carboxyterminus. The sixth was synthesized by fragment condensation (5 + 10 coupling). Antibodies to synthetic peptides were then used to locate exposed and buried regions in the membrane glycoproteins. 相似文献
9.
The VITA Project: C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism 总被引:4,自引:0,他引:4
ALBERTO TOSETTO EDOARDO MISSIAGLIA MAURIZIO FREZZATO & FRANCESCO RODEGHIERO 《British journal of haematology》1997,97(4):804-806
We evaluated the hypothesis that a common polymorphism of the methylenetetrahydrofolate reductase gene (C677T), which results in increased levels of plasma homocysteine, may be a putative risk factor for venous thromboembolism (VT). Sixty-five cases of VT and 130 controls, both identified within the framework of an epidemiologic survey on thrombophilia, the Vicenza Thrombophilia and Arteriosclerosis (VITA) Project, were genotyped for the mutation. No increased risk of VT was found in carriers of the mutation. We conclude that screening for the C677T mutation of the methylenetetrahydrofolate reductase gene should not be recommended in unselected patients with VT. 相似文献
10.
Hodgkins disease, lymphosarcoma, and acute leukemia have been studiedafter treatment with the Vinca rosea alkaloids (vinblastine and vincristine), inorder to demonstrate and evaluate the mitosis-arresting effects of the twodrugs on the malignant cells. Histologic sections, lymph node and bone marrow aspirations were performed immediately before and 24 hours after theintravenous administration of the drugs in 15 cases of Hodgkins disease, 12 oflymphoblastic lymphosarcoma, and 12 of acute leukemia, besides other miscellaneous cases.In Hodgkins disease aspirates and sections showed a clear-cut metaphasearrest in the post-VLB specimens, chiefly affecting the pre-Sternberg or Hodgkin cells. This effect, besides corroborating the fundamentally stathmokineticmechanism of VLB in Hodgkins disease, was considered an additional factorin confirming the widely proposed conception that these cells represent thefundamentally proliferating and malignant tissue of this disease.In the acute leukemias and lymphoblastosarcomas, cytomorphologic andquantitative studies demonstrated that the oncolytic effects correlated wellwith the magnitude of metaphasic blockade. It is postulated that only activelyproliferating cellsthe so-called "growth fraction"are the target for thesealkaloids. Submitted on January 30, 1966 Accepted on June 26, 1966 相似文献