阻塞性睡眠呼吸暂停低通气综合征患者经鼻持续气道正压通气治疗前后血清IL-6水平的变化

目的观察阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患者在经经鼻持续气道正压通气(nCPAP)治疗前后血清白细胞介素6(IL-6)水平的变化.方法选择OSAHS患者30例和正常对照组28例,测定并比较两组血清IL-6的水平,同时对中重度OSAHS患者进行nCPAP治疗1周,测定治疗后的血清IL-6水平,并与治疗前相比较.结果 OSAHS组血清IL-6水平明显高于正常对照组(P＜0.05).OSAHS组血清IL-6水平与睡眠呼吸暂停低通气指数(AHI)、体重指数(BMI)、血氧饱和度(SaO2)＜90%占总睡眠时间百分比呈正相关;与最低SaO2、平均最低SaO2呈负相关.经过nCPAP治疗后,OSAHS患者血清IL-6水平明显下降(P＜0.05).结论血清IL-6与OSAHS密切相关,可能预示着心血管疾病发生的危险性,而nCPAP治疗可能降低这个危险因素.     

一氧化氮与慢性阻塞性肺疾病相关性研究

慢性阻塞性肺疾病(COPD)是50～60岁以上老年人的常见病和多发病,以呼出气流下降,气道阻力增加,肺过度充气为特征.有关血清一氧化氮(NO)与COPD血小板功能相关性的报道不多,为此,我们对NO、内皮型一氧化氮合酶(eNOS)进行了观察,探讨NO在COPD发生、发展中的作用.     

老年急性嗜酸性粒细胞肺炎1例并文献复习

目的 探讨急性嗜酸性粒细胞肺炎的临床特点及诊疗方法。方法 对该患者行经气管肺部灌洗和肺组织活检,并给予糖皮质激素治疗,观察患者肺部影像学变化趋势。结果 经气管肺部灌洗和肺组织活检确诊后,给予糖皮质激素治疗,患者症状明显好转,胸部炎症渗出完全吸收。结论 急性嗜酸性粒细胞肺炎的临床症状不典型,可经气管肺部灌洗和肺组织活检确诊,且糖皮质激素治疗快速有效,一般预后良好。     

阻塞性睡眠呼吸暂停低通气综合征患者糖、脂代谢紊乱的研究

目的通过观察OSAHS患者血清内脂素、血糖、甘油三酯水平的变化,探讨糖脂代谢紊乱与0sAHS的相关性。方法选择OsAHS患者45例,轻度OSAHS患者组20例,中重度0sAHS患者组25例。选择正常对照组20例。采取酶联免疫吸附法（ELISA）测定空腹血清内脂素的浓度,常规检测血糖、甘油三酯。结果轻度及中重度OSAHS组与正常对照组比较,血清内脂素水平均升高（F=38．59,P〈0．01）;中重度OsAHS组与轻度OSAHS组比较,血清内脂素水平升高（t=2．93,P〈0．01）。轻度OSAHS组与正常对照组比较,甘油三酯水平升高（t=2．97,P〈0．01）。血糖升高不明显（t=1．58,P〉O．05）;中重度0sAHS组与正常对照组比较,甘油三酯、血糖水平均升高（t=4．26,3．01,P值均〈0．01）。中重度0sAHs组与轻度0sAHS组比较,甘油三酯、血糖水平升高（t=3．12,2．93,P值均〈O．01）。血清内脂素与反映睡眠呼吸严重程度的指标有相关性（r=0．83,0．615,0．715,0．642,0．710,P值均〈O．01）。结论0sAHS患者存在血清内脂素、血糖、甘油三酯水平的异常,且与OSAHS的病情严重程度相关,说明0SAHS与糖脂代谢紊乱具有相关性。     

The changes of plasma 8-iso-prostaglandin F2αand serum C-reactive protein levels in patients with obstructive sleep apnea-hypopnea syndrome

Objective To investigate the plasma 8-iso-prostaglandin F2α(8-iso-PGF2α and the serum C-re-active protein(CRP) levels in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) with and without hypertension(OSAHS + HT),and to explore the changes of pathophysiology in patients with OSAHS and the patho-genesis of OSAHS + HT. Methods All observed subjects were divided into 3 groups: control group (n=20),OS-AHS group(n=19),OSAHS + HT group (n=21). Plasma 8-iso-PGF2αand serum CRP concentrations levels were measured by ELISA and were compared. Results The plasma 8-iso-PGF2αand serum CRP levels,were higher in OSAHS patients than those in control subjects [(11.08±3.26)μg/L vs (7.49±2.10)μg/L,P<0.01;(1.75±0.82) mg/L vs (0.52±0.26 ) mg/L,P<0.01],and were higher in OSAHS + HT group than those in control group [14.84±3.43)μG/L vs(11.08±3.26)μg/L,P<0.01 ;(3.13±1.06)mg/L vs(1.75±0.82)mg/L,P<0.01]. Conclusions Oxidative stress and inflammation in OSAHS patients are increased,which are involved in the devel-opment of OSAHS associated hypertension.     

肿瘤坏死因子-α、白介素-8在阻塞性睡眠呼吸暂停低通气综合征患者及其合并冠心病发病中的作用

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是不稳定型心绞痛、心肌梗死等动脉粥样硬化性疾病独立危险因素.但其机制尚不清楚.本文观察OSAHS患者及其合并冠心病(CHD)患者血清肿瘤坏死因子(TNF)-α、白介素(IL)-8水平的变化,探讨细胞因子在OSAHS及其合并CHD发生发展中作用.     

阻塞性睡眠呼吸暂停低通气综合征红细胞免疫功能的研究

目的 探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者红细胞免疫功能的变化以及两者之间的关系.方法 选择OSAHS患者及健康对照组各30例,测定其红细胞C3b受体花环率及红细胞免疫复合物花环率,并评价其相互关系.结果 OSAHS患者红细胞C3b受体花环率显著低于对照组(P<0.01),红细胞免疫复合物花环率显著高于对照组(P<0.01).结论 OSAHS患者存在红细胞免疫功能降低,对OSAHS病情进展可能具有一定的意义.     

The changes of plasma 8-iso-prostaglandin F2αand serum C-reactive protein levels in patients with obstructive sleep apnea-hypopnea syndrome

Objective To investigate the plasma 8-iso-prostaglandin F2α(8-iso-PGF2α and the serum C-re-active protein(CRP) levels in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) with and without hypertension(OSAHS + HT),and to explore the changes of pathophysiology in patients with OSAHS and the patho-genesis of OSAHS + HT. Methods All observed subjects were divided into 3 groups: control group (n=20),OS-AHS group(n=19),OSAHS + HT group (n=21). Plasma 8-iso-PGF2αand serum CRP concentrations levels were measured by ELISA and were compared. Results The plasma 8-iso-PGF2αand serum CRP levels,were higher in OSAHS patients than those in control subjects [(11.08±3.26)μg/L vs (7.49±2.10)μg/L,P<0.01;(1.75±0.82) mg/L vs (0.52±0.26 ) mg/L,P<0.01],and were higher in OSAHS + HT group than those in control group [14.84±3.43)μG/L vs(11.08±3.26)μg/L,P<0.01 ;(3.13±1.06)mg/L vs(1.75±0.82)mg/L,P<0.01]. Conclusions Oxidative stress and inflammation in OSAHS patients are increased,which are involved in the devel-opment of OSAHS associated hypertension.     

The changes of plasma 8-iso-prostaglandin F2αand serum C-reactive protein levels in patients with obstructive sleep apnea-hypopnea syndrome

Objective To investigate the plasma 8-iso-prostaglandin F2α(8-iso-PGF2α and the serum C-re-active protein(CRP) levels in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) with and without hypertension(OSAHS + HT),and to explore the changes of pathophysiology in patients with OSAHS and the patho-genesis of OSAHS + HT. Methods All observed subjects were divided into 3 groups: control group (n=20),OS-AHS group(n=19),OSAHS + HT group (n=21). Plasma 8-iso-PGF2αand serum CRP concentrations levels were measured by ELISA and were compared. Results The plasma 8-iso-PGF2αand serum CRP levels,were higher in OSAHS patients than those in control subjects [(11.08±3.26)μg/L vs (7.49±2.10)μg/L,P<0.01;(1.75±0.82) mg/L vs (0.52±0.26 ) mg/L,P<0.01],and were higher in OSAHS + HT group than those in control group [14.84±3.43)μG/L vs(11.08±3.26)μg/L,P<0.01 ;(3.13±1.06)mg/L vs(1.75±0.82)mg/L,P<0.01]. Conclusions Oxidative stress and inflammation in OSAHS patients are increased,which are involved in the devel-opment of OSAHS associated hypertension.