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排序方式: 共有259条查询结果,搜索用时 15 毫秒
1.
Objective To investigate the oxidative stress state in children with diabetic ketoacidosis (DKA),and analyze whether any observed abnormalities were related to metabolic disturbances.Methods Four groups of subjects were studied,comprising with 22 patients with DKA(group 1),18 diabetic children with medium metabolic control,whose glycated hemoglobin(HbAlc) below 9%(group 2),22 children with poorly controlled diabetes,whose Hbal c above 9%(group 3),and 36 healthy control children(group 4).Malondialdehyde(MDA),nitrate oxidase(NO),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),and metabolic parameters such as fasting blood glucose,HbAlc,blood gas analysis,serum ion,renal function of the subjects were measured.Results Mean serum MDA value was significantly higher in group 1 than in group 2(P <0.01) and group 4(P <0.01),but was not different from that in group 3 (P >0.05).Serum levels of NO were significantly higher in group 1,2 and 3 compared with group 4(P<0.01).Serum levels of GSH-Px were significantly lower in group 1,2 and 3 than in group 4(P<0.01).There were no significant differences of serum SOD value among the four groups(P>0.05).Both serum MDA and NO values in the diabetic patients(groups 1 +2 +3) were positively related to HbAlc(r=0.375,P <0.01;r=0.250,P <0.05),and serum SOD values in the DKA patients were negatively related to HbAlc(r= -0.507,P<0.05),there were not any significant relationship between the other oxidative markers and metabolic parameters.Conclusion There is an increase of oxidative stress and decrease of antioxygenic ability in DKA children,and these changes tend to correlate more with markers of diabetic imbalance than with parameters of acute metabolic disturbances of DKA. 相似文献
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Objective To investigate the oxidative stress state in children with diabetic ketoacidosis (DKA),and analyze whether any observed abnormalities were related to metabolic disturbances.Methods Four groups of subjects were studied,comprising with 22 patients with DKA(group 1),18 diabetic children with medium metabolic control,whose glycated hemoglobin(HbAlc) below 9%(group 2),22 children with poorly controlled diabetes,whose Hbal c above 9%(group 3),and 36 healthy control children(group 4).Malondialdehyde(MDA),nitrate oxidase(NO),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),and metabolic parameters such as fasting blood glucose,HbAlc,blood gas analysis,serum ion,renal function of the subjects were measured.Results Mean serum MDA value was significantly higher in group 1 than in group 2(P <0.01) and group 4(P <0.01),but was not different from that in group 3 (P >0.05).Serum levels of NO were significantly higher in group 1,2 and 3 compared with group 4(P<0.01).Serum levels of GSH-Px were significantly lower in group 1,2 and 3 than in group 4(P<0.01).There were no significant differences of serum SOD value among the four groups(P>0.05).Both serum MDA and NO values in the diabetic patients(groups 1 +2 +3) were positively related to HbAlc(r=0.375,P <0.01;r=0.250,P <0.05),and serum SOD values in the DKA patients were negatively related to HbAlc(r= -0.507,P<0.05),there were not any significant relationship between the other oxidative markers and metabolic parameters.Conclusion There is an increase of oxidative stress and decrease of antioxygenic ability in DKA children,and these changes tend to correlate more with markers of diabetic imbalance than with parameters of acute metabolic disturbances of DKA. 相似文献
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目的探讨糖尿病足患者给予预防性护理干预的效果.方法将2010年1月~2011年2月收治的58例糖尿病患者随机分为两组.对照组给予常规临床护理,试验组患者给予预防性护理,比较半年后患者的知识了解情况和患者遵医行为.结果试验组患者经过预防性护理后,其足部溃疡发生少,患者对疾病知识了解更好,其自护行为得分更高,与对照组比较有显著差异,P<0.05.结论对糖尿病足患者给予预防性护理干预能够取得较好的效果,提高患者自我能力,减少糖尿病足的发生发展 相似文献
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小学英语词汇课堂教学中开展情境教学,可以提升学生思考能力,为学生的各项发展提供了各种可能性,促进学生多方面的发展。教师要将生活与教学相结合,让教学重点、难点贯穿于教学情境的教学中。 相似文献
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目的:观察蛛网膜下腔应用舒芬太尼对腹腔镜手术患者呼吸功能的影响,以了解舒芬太尼蛛网膜下腔注射在腹腔镜手术患者中应用的安全性。方法:选择择期行腹腔镜手术治疗的宫外孕患者45例,分为B组、S组、G组3组,每组15例。3组患者均在L2~3处穿刺行布比卡因15mg腰麻,B组为对照组,S组患者腰麻液中加舒芬太尼5μg,G组患者腰麻15min后行气管插管全麻。若术中血压高于麻醉诱导前的20%或心率快于100次/min、患者自诉不适及体动时静脉追加丙泊酚。记录基础,腰麻后10min,气腹后0、10、20、30min,放气时,术毕各时点的潮气量(VT)、呼吸频率(RR)、分钟通气量(VE)、顺应性(C)。记录基础,气腹前、后10、20、30min,放气后10min时点的呼气末二氧化碳分压(PETCO2)和动脉二氧化碳分压(PaCO2)。结果:3组患者腰麻后VT略有下降,气腹后上升;B、S组患者RR在气腹后加快;G组患者在气腹后顺应性下降30%~40%;3组患者PaCO2、PETCO2在气腹后上升,至气腹后30min达高峰,放气后下降;3组患者PETCO2放气后10min仍高于基础值(P<0.05);S组PETCO2在放气后10min比B组低(P<0.05)。结论:舒芬太尼5μg蛛网膜下腔注射对腹腔镜手术患者的呼吸功能影响不大。 相似文献
8.
目的探讨黄芪建中汤对脾胃虚寒证胃溃疡大鼠的影响。方法将SD大鼠随机分为正常组、模型组、埃索美拉唑组(4.17 mg/kg)及黄芪建中汤低、高剂量组(9.27、18.54 g/kg)。采用番泻叶(10 m L/kg)联合游泳力竭法建立脾胃虚寒证候模型,无水乙醇(10 m L/kg)联合阿司匹林肠溶片(200 mg/kg)建立胃溃疡模型。观察并记录大鼠的整体状态、体质量、进食量、饮水量和肛温,肉眼及HE染色观察胃黏膜组织形态学损伤,测量胃液总酸度和胃蛋白酶活性,ELISA法检测大鼠血清IL-4、IL-10、NO和TNF-α水平,qRT-PCR和免疫组化法分别检测TLR-2、MyD88 mRNA及蛋白表达。结果与模型组比较,黄芪建中汤组大鼠体质量、进食量、饮水量和肛温均上升(P<0.05,P<0.01),溃疡指数下降(P<0.01),胃酸总酸度和胃蛋白酶活性均降低(P<0.01),血清TNF-α水平下降(P<0.05、P<0.01),IL-4、IL-10和NO水平上升(P<0.05、P<0.01),胃组织中TLR-2、MyD88 mRNA及蛋白表达下调(P<0.01)。结论黄芪建中汤对脾胃虚寒型胃溃疡大鼠有显著的疗效,其作用机制可能通过调节TLR-2/MyD88信号通路,影响炎性因子表达,下调黏膜攻击因子水平,从而加速胃黏膜溃疡修复。 相似文献
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笔者自2002年2月-2008年2月采用宁心安神汤治疗失眠症78例,取得较满意疗效,并与用地西泮治疗的69例作对照观察,现报告如下。 相似文献