热性惊厥患儿血清褪黑素水平和细胞免疫功能的变化及其临床意义

Objective To investigate the changes of melatonin and cellular immunological function in children with febrile seizures and its clinical significance. Methods 50 children, including 23 cases with complex febrile seizure (CFS) and 27 cases with simple febrile seizure (SFS) , and 25 cases with upper respiratory infections children selected as control group were enrolled in this study. Serum melato- nin was measured by enzyme-linked immunosorbent assay (ELISA) and cellular immunological function was measured by flow eytomcter. Results The levels of serum melatonin in the 3 groups of CFS, SFS, control were(14. 91±2. 61) ng/L, (20. 72±2. 54) ng/L, (23.93± 2. Ol) ng/L, respectively. The melatonin levels in CFS children were significantly decreased than that in control group and SFS children (P <0. O1). CD3 + ,CD4 +, the ratio of CD4 + /CD8 + and CD8 + in CFS group were significantly decreased than that in control group and SFS group (P <0.01). The ratio of CD4 +/CD8 + in SFS group was significantly decreased than that in control group (P <0.05), but CD3 + ,CD4 + and CD8 + had no statistics significance among these groups(P >0. 05). The serum rnelatonin level were positive related withdecreaseddegreeofCD3+,CD4+ andtberatioofCD4+ /CDS+ (r≥0. 472, P <0.05). Conclusion The disorder cfcellular immunological function was possible related with the loss of serum melatonin, and the loss of serum melatonin maybe one of the reasons for febrile seizures relapse and brain injured.     

高氧液治疗脑弥漫性轴索损伤患者的疗效评定

[目的]探讨早期静脉输注高氧液对脑弥漫性轴索损伤的治疗疗效. [方法]纳入我院2000年1月～2007年1月住院的脑弥漫性轴隶损伤病人162例,随机分为早期静脉输注高氧液组(84例)和对照组(78例),于治疗前后行神经元特异性烯醇化酶含量(NSE)的测定,同时评定格拉斯哥昏迷评分(GCS)的变化. [结果]经高氧液治疗,治疗组NSE明显降低,而GCS评分在治疗后20 d、30 d较对照组明显增加,与对照组相比有统计学差异(P<0.01). [结论]早期静脉氧疗可显著减轻脑组织的病损程度,降低死亡率.     

热性惊厥患儿血清褪黑素水平和细胞免疫功能的变化及其临床意义

Objective To investigate the changes of melatonin and cellular immunological function in children with febrile seizures and its clinical significance. Methods 50 children, including 23 cases with complex febrile seizure (CFS) and 27 cases with simple febrile seizure (SFS) , and 25 cases with upper respiratory infections children selected as control group were enrolled in this study. Serum melato- nin was measured by enzyme-linked immunosorbent assay (ELISA) and cellular immunological function was measured by flow eytomcter. Results The levels of serum melatonin in the 3 groups of CFS, SFS, control were(14. 91±2. 61) ng/L, (20. 72±2. 54) ng/L, (23.93± 2. Ol) ng/L, respectively. The melatonin levels in CFS children were significantly decreased than that in control group and SFS children (P <0. O1). CD3 + ,CD4 +, the ratio of CD4 + /CD8 + and CD8 + in CFS group were significantly decreased than that in control group and SFS group (P <0.01). The ratio of CD4 +/CD8 + in SFS group was significantly decreased than that in control group (P <0.05), but CD3 + ,CD4 + and CD8 + had no statistics significance among these groups(P >0. 05). The serum rnelatonin level were positive related withdecreaseddegreeofCD3+,CD4+ andtberatioofCD4+ /CDS+ (r≥0. 472, P <0.05). Conclusion The disorder cfcellular immunological function was possible related with the loss of serum melatonin, and the loss of serum melatonin maybe one of the reasons for febrile seizures relapse and brain injured.     

癫痫患儿与正常儿童气质的差异性研究

目的探讨癫痫患儿与正常儿童气质的差别。方法随机入选2007-2008年我院儿科确诊的42名癫痫患儿及56名非癫痫正常儿童,进行气质测定。结果（1）癫疴组与正常儿童组气质类型分布存在显著性差异（χ2=6．417,P=0．040）;（2）癫痫患儿在活动水平、节律性、适应性、坚持性、情绪本质等气质维度的得分比正常儿童高,且具有统计学差异（P〈0．05）。结论癫痫疾病对儿童的气质特点具有显著的影响,使患儿的气质偏向消极。     

热性惊厥患儿血清褪黑素水平和细胞免疫功能的变化及其临床意义

Objective To investigate the changes of melatonin and cellular immunological function in children with febrile seizures and its clinical significance. Methods 50 children, including 23 cases with complex febrile seizure (CFS) and 27 cases with simple febrile seizure (SFS) , and 25 cases with upper respiratory infections children selected as control group were enrolled in this study. Serum melato- nin was measured by enzyme-linked immunosorbent assay (ELISA) and cellular immunological function was measured by flow eytomcter. Results The levels of serum melatonin in the 3 groups of CFS, SFS, control were(14. 91±2. 61) ng/L, (20. 72±2. 54) ng/L, (23.93± 2. Ol) ng/L, respectively. The melatonin levels in CFS children were significantly decreased than that in control group and SFS children (P <0. O1). CD3 + ,CD4 +, the ratio of CD4 + /CD8 + and CD8 + in CFS group were significantly decreased than that in control group and SFS group (P <0.01). The ratio of CD4 +/CD8 + in SFS group was significantly decreased than that in control group (P <0.05), but CD3 + ,CD4 + and CD8 + had no statistics significance among these groups(P >0. 05). The serum rnelatonin level were positive related withdecreaseddegreeofCD3+,CD4+ andtberatioofCD4+ /CDS+ (r≥0. 472, P <0.05). Conclusion The disorder cfcellular immunological function was possible related with the loss of serum melatonin, and the loss of serum melatonin maybe one of the reasons for febrile seizures relapse and brain injured.     

127例喉癌患者围手术期的护理体会

目的总结喉癌围手术期患者术前、术后的护理经验。方法对127例喉癌患者进行规范的术前术后护理及出院指导。结果经过规范的专科护理,127例患者术后均恢复良好无1例发生护理并发症。结论对喉癌患者围手术期的有效护理,可以明显提高喉癌患者术后生活质量,减轻术后疼痛,减少并发症。围手术期的护理对喉癌患者手术有很重要的作用。     

突发性耳聋患者焦虑状况分析及护理对策

目的探讨分析突发性耳聋患者焦虑状况以及护理干预对患者焦虑心理的影响。方法对本院收治的454例突发性耳聋患者焦虑状况进行分析,并采用有效的护理措施,使患者情绪镇静,减轻其焦虑心理。结果所有患者的焦虑心理明显得到改善,患者焦虑状况得以减轻,提高了治疗效果。结论护理干预可减轻突发性耳聋患者的焦虑心理,提高了治疗效果,促进其恢复。     

热性惊厥患儿血清褪黑素水平和细胞免疫功能的变化及其临床意义

Objective To investigate the changes of melatonin and cellular immunological function in children with febrile seizures and its clinical significance. Methods 50 children, including 23 cases with complex febrile seizure (CFS) and 27 cases with simple febrile seizure (SFS) , and 25 cases with upper respiratory infections children selected as control group were enrolled in this study. Serum melato- nin was measured by enzyme-linked immunosorbent assay (ELISA) and cellular immunological function was measured by flow eytomcter. Results The levels of serum melatonin in the 3 groups of CFS, SFS, control were(14. 91±2. 61) ng/L, (20. 72±2. 54) ng/L, (23.93± 2. Ol) ng/L, respectively. The melatonin levels in CFS children were significantly decreased than that in control group and SFS children (P <0. O1). CD3 + ,CD4 +, the ratio of CD4 + /CD8 + and CD8 + in CFS group were significantly decreased than that in control group and SFS group (P <0.01). The ratio of CD4 +/CD8 + in SFS group was significantly decreased than that in control group (P <0.05), but CD3 + ,CD4 + and CD8 + had no statistics significance among these groups(P >0. 05). The serum rnelatonin level were positive related withdecreaseddegreeofCD3+,CD4+ andtberatioofCD4+ /CDS+ (r≥0. 472, P <0.05). Conclusion The disorder cfcellular immunological function was possible related with the loss of serum melatonin, and the loss of serum melatonin maybe one of the reasons for febrile seizures relapse and brain injured.     

左乙拉西坦单药治疗6个月至4岁癫(癎)患儿的临床疗效、维持剂量及安全性研究

目的 评价左乙拉西坦单药治疗6个月至4岁癫(癎)患儿的临床疗效、维持剂量及安全性.方法 对本院6个月至4岁癫(癎)患儿(40例)采用左乙拉西坦单药治疗,起始剂量10 mg/(kg·d),分2次口服,根据癫(癎)发作情况每周增加左乙拉西坦剂量5～10mg/(kg·d),最后维持剂量为10 ～50 mg/(kg·d).维持剂量治疗6个月,每3个月定期复诊,复查血常规、尿常规、肝肾功能及脑电图,同时记录癫(癎)发作次数和不良反应.结果 45％ (18/40)的患儿癫(癎)发作完全控制,显效9例(22.5％),有效3例(7.5％),总有效率75％ (30/40).维持剂量10～20 mg/(kg·d)5例;＞20～ 30 mg/(kg·d)者16例;＞ 30～40 mg/(kg·d)者10例;＞40 ～50 mg/(kg ·d)者8例;平均维持剂量34.8 mg/(kg·d).左乙拉西坦可减少(癎)样放电,改善患儿脑电图.40例癫(癎)患儿中有1例因皮疹而停药,6例患儿出现不良反应,不良反应轻微,在治疗约l周左右后自行缓解.结论 左乙拉西坦单药治疗6个月至4岁癫(癎)患儿疗效较好,维持剂量小,不良反应轻且持续时间短,是一种安全性好、疗效佳的新型抗癫(癎)药.     

冲洗法在经口气管插管患者口腔护理中的应用

目的探讨冲洗法对经口气管插管患者口腔护理的临床疗效。方法采用前瞻性研究方法对汕头大学医学院第一附属医院2011年5月~2014年11月住院治疗的71例经口气管插管危重症患者进行分析,将入院病历号按随机数字表法分为观察组(35例)与对照组(36例)。两组患者均行常规的治疗和护理。观察组患者采用冲洗法行口腔护理,对照组患者行传统的口腔护理方法。观察两组患者的牙菌斑指数、口腔异味、咽拭子细菌培养结果及呼吸机相关性肺炎(VAP)发生情况。结果观察组患者口腔护理操作第1、3、5、7天牙菌斑指数分别为(3.0±0.4)、(2.4±0.2)、(2.1±0.3)、(2.1±0.2)分,对照组分别为(3.1±0.6)、(2.8±0.3)、(2.6±0.1)、(2.4±0.1)分,两组第1天比较差异无统计学意义(P>0.05),第3、5、7天比较差异均有统计学意义(均P<0.05)。观察组患者口臭、咽拭子细菌培养阳性及VAP发生率分别为8.6%、8.6%、5.7%,对照组分别为36.1%、33.3%、27.8%,两组比较差异均有统计学意义(均P<0.05)。结论冲洗法对经口气管插管患者保持口腔清洁有效,降低了口腔感染及VAP并发症的发生,对患者的刺激性小,提高了患者的舒适度,是操作简单、效果可靠的一种方法,值得临床推广应用。