家兔静注蝮蛇抗栓酶的药物动力学

以家兔凝血时间的延长作为分级定量的药理指标,测定了蝮蛇抗栓酶 iv 给药的药动学参数和 ig给药的生物利用度。按二室开放模型拟合的结果如下:t_(1/2α)=1.12h;t_(1/2β)=3.8h;k_(12)=0.039h~(-1);k_(21)=0.56h~(-1);k_(10)=0.21h~(-1);CL=0.021kg/kg·h;V_c=0.098kg/kg;V_p=0.0069kg/kg;V_(ss)=0.105kg/kg;F=10.9%。     

CLINICAL AND IMMUNOLOGIC ANALYSIS OF 25 SJOGREN'S SYNDROME CASES

The results of clinical and immunologic stu- dies of 25 Sjogren's syndrome (SS) ca,ses are presented. Multiple system involvement was observed. The immunologic studies showed that both humoral and cell-mediated immunity were impaired. The premature loss of suppressor T- cells may be the primary deficiency. A com- parison of the histopathologic features of minor salivary glands with the sialographic patt.erns in SS patients wa.s made. Labial biopsy is as sensitive a diagnostic test a.s sialography.     

蛇岛蝮蛇毒中精氨酸酯酶的抗凝实验与临床应用

精氨酸酯酶对狗血液粘度影响的实验研究蝮蛇毒是以血循毒为主、含有明显的抗凝组分(2～4)、蛇岛产蝮蛇毒除有抗癌作用之外(5),是否也有抗凝作用。为此、我们进行了蛇岛蝮蛇毒对狗的血液粘度影响实验研究,现将其实验结果报告如下。     

蝮蛇抗栓酶对家兔抗凝血作用的药效动力学

<正> 蝮蛇抗栓酶(ahylysantinfarctase)是从东北陆生白眉短尾蝮蛇(Agkistrodon halys brevicaudus Stejneger)毒中分离得到的以精氨酸酯酶为主的酶制剂,具有抗凝和溶纤作用。为了解其iv给药后的药效动力学,本研究以家兔为实验对象,用毛细玻管法测定凝血时间,以给药后凝血时间的延长率为药理效应指标,观察了蝮蛇抗栓酶抗凝作用的量效关系和时效关系,并求出有关参数。结果如下: 1.剂量-效应关系:成年家兔24只,随机分成6组。iv蝮蛇抗栓酶0.15～0.40mg/kg时,其对家兔的抗凝