全文获取类型
收费全文 | 14084篇 |
免费 | 1270篇 |
国内免费 | 1056篇 |
专业分类
耳鼻咽喉 | 133篇 |
儿科学 | 154篇 |
妇产科学 | 126篇 |
基础医学 | 1737篇 |
口腔科学 | 290篇 |
临床医学 | 1978篇 |
内科学 | 2041篇 |
皮肤病学 | 116篇 |
神经病学 | 716篇 |
特种医学 | 508篇 |
外国民族医学 | 12篇 |
外科学 | 1243篇 |
综合类 | 2602篇 |
现状与发展 | 2篇 |
一般理论 | 1篇 |
预防医学 | 779篇 |
眼科学 | 417篇 |
药学 | 1595篇 |
13篇 | |
中国医学 | 810篇 |
肿瘤学 | 1137篇 |
出版年
2024年 | 44篇 |
2023年 | 262篇 |
2022年 | 570篇 |
2021年 | 740篇 |
2020年 | 530篇 |
2019年 | 491篇 |
2018年 | 491篇 |
2017年 | 469篇 |
2016年 | 425篇 |
2015年 | 631篇 |
2014年 | 799篇 |
2013年 | 705篇 |
2012年 | 1007篇 |
2011年 | 1209篇 |
2010年 | 645篇 |
2009年 | 567篇 |
2008年 | 730篇 |
2007年 | 734篇 |
2006年 | 748篇 |
2005年 | 757篇 |
2004年 | 483篇 |
2003年 | 403篇 |
2002年 | 384篇 |
2001年 | 292篇 |
2000年 | 303篇 |
1999年 | 393篇 |
1998年 | 255篇 |
1997年 | 251篇 |
1996年 | 162篇 |
1995年 | 161篇 |
1994年 | 128篇 |
1993年 | 93篇 |
1992年 | 95篇 |
1991年 | 90篇 |
1990年 | 92篇 |
1989年 | 57篇 |
1988年 | 44篇 |
1987年 | 32篇 |
1986年 | 39篇 |
1985年 | 41篇 |
1984年 | 27篇 |
1983年 | 12篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 2篇 |
1979年 | 6篇 |
1976年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Zeyu Li Erwei Hao Rui Cao Si Lin Linghui Zou Tianyan Huang Zhengcai Du Xiaotao Hou Jiagang Deng 《中草药(英文版)》2022,14(4):479-493
Zedoary tumeric (Curcumae Rhizoma, Ezhu in Chinese) has a long history of application and has great potential in the treatment of liver cancer. The anti liver cancer effect of zedoary tumeric depends on the combined action of multiple pharmacodynamic substances. In order to clarify the specific mechanism of zedoary tumeric against liver cancer, this paper first analyzes the mechanism of its single pharmacodynamic substance against liver cancer, and then verifies the joint anti liver cancer mechanism of its "pharmacodynamic group". By searching the research on the anti hepatoma effect of active components of zedoary tumeric in recent years, we found that pharmacodynamic substances, including curcumol, zedoarondiol, curcumenol, curzerenone, curdione, curcumin, germacrone, β-elemene, can act on multi-target and multi-channel to play an anti hepatoma role. For example, curcumin can regulate miR, GLO1, CD133, VEGF, YAP, LIN28B, GPR81, HCAR-1, P53 and PI3K/Akt/mTOR, HSP70/TLR4 and NF-κB. Wnt/TGF/EMT, Nrf2/Keap1, JAK/STAT and other pathways play an anti hepatoma role. Network pharmacological analysis showed that the core targets of the "pharmacodynamic group" for anti-life cancer are AKT1, EGFR, MAPK8, etc, and the core pathways are neuroactive live receiver interaction, nitrogen metabolism, HIF-1 signaling pathway, etc. At the same time, by comparing and analyzing the relationship between the specific mechanisms of pharmacodynamic substance and "pharmacodynamic group", it is found that they have great reference significance in target, pathway, biological function, determination of core pharmacodynamic components, formation of core target protein interaction, in-depth research of single pharmacodynamic substance, increasing curative effect and so on. By analyzing the internal mechanism of zedoary tumeric pharmacodynamic substance and "pharmacodynamic group" in the treatment of liver cancer, this paper intends to provide some ideas and references for the deeper pharmacological research of zedoary tumeric and the relationship between pharmacodynamic substance and "pharmacodynamic group". 相似文献
2.
瞬时受体电位亚家族V成员6 (Transient Receptor Potential Channel Subfamily V Member 6, TRPV6) 是一种钙离子高度选择性离子通道,在多种组织中均有表达,控制细胞顶端钙离子的进入,在维持钙稳态中发挥重要作用。TRPV6功能异常会影响体内钙稳态,进而引发新生儿骨骼发育异常、甲状旁腺功能亢进、骨与软骨代谢异常、肾结石和高尿钙症、 以及炎症性肠病和慢性胰腺炎等多种疾病。近年来研究也表明,TRPV6的上调与多种肿瘤的侵袭性增加有关,具有作为肿瘤检测的标志物以及治疗靶点的潜力。本综述将聚焦于TRPV6与其在相关疾病中发挥的作用,旨在为TRPV6作为药物靶点实现临床转化提供理论依据。 相似文献
3.
Clinical and Experimental Medicine - Recently, the use of novel targeted drugs significantly improved the overall response rate (ORR) and survival of patients with relapsed/refractory chronic... 相似文献
4.
5.
6.
7.
Ju Zou Daichao Wu Tao Li Xianwen Wang Yan Liu Sijie Tan 《Pathology, research and practice》2019,215(2):229-234
Programmed death ligand 1(PD-L1) mediated immune escape play important roles in the development of cancer. The gene polymorphism of PD-L1, in particular rs4143815 C?>?G, has been associated with the cancer risks, but with conflicting results. Therefore, this meta-analysis was aimed to assess the association between rs4143815 C?>?G and cancer susceptibility. A systematic literature search was performed to select the studies and the pooled odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of association. Eleven eligible studies containing 3711 cases and 3704 controls were enrolled in the meta-analysis. The results suggested that there is a strong association between rs4143815 C?>?G and the cancer risks (G vs. C: OR?=?1.386, 95% CI: 1.132–1.696, p?=?0.002; GG vs. CG?+?CC: OR?=?1.843 95% CI: 1.300–2.613, p?=?0.002; GG?+?CG vs. CC: OR?=?1.280, 95% CI: 1.040–1.576, p?=?0.020). Subgroup analysis based on cancer type suggested that PD-L1 rs4143815 C?>?G might increase the susceptibility to gastric cancer (G vs. C: OR?=?1.842, 95% CI: 1.403–2.418, p?<?0.001) and bladder cancer (G vs. C: OR?=?2.015, 95% CI: 1.556–2.608, p?<?0.001), and genotype GG carriers of PD-L1 rs4143815 C?>?G might have higher risks of HCC (GG vs. CG?+?CC: OR?=?2.226 95% CI: 1.562–3.172, p?<?0.001). PD-L1 rs4143815 C?>?G might confer an increased cancer risk, indicating this SNP may contribute to the pathogenesis of cancer and might be used as a potential biomarker to predict the susceptibility to cancer. 相似文献
9.
苏州科技城医院坐落于苏州高新区太湖之滨,由苏州高新区政府投资新建,是一所集医疗、科研、康复、预防于一体的三级综合性公立医院。医院占地面积140亩,总建筑面积180000m~2,总投资额16亿,设计床位1200张。医院于2013年9月29日奠基,2014年12月28日主体封顶,2016年4月正式投入使用,比预定日期提前了将近1年! 相似文献
10.