A study on relationship of nitric oxide, oxidation, peroxidation, lipoperoxidation with chronic chole-cystitis

AIM To study relationship of injury induced by nitric oxide, oxidation, peroxidation, lipoperoxidation with chronic cholecystitis. METHODS The values of plasma nitric oxide (PNO), plasma vitamin C (P-VC), plasma vitamin E ( P-VE ), plasma β-carotene ( P-β-CAR ), plasma lipoperoxides (P-LPO), erythrocyte superoxide dismutase (E-SOD), erythrocyte catalase (ECAT), erythrocyte glutathione peroxidase (E-GSHPx) activities and erythrocyte lipoperoxides (ELPO) level in 77 patients with chronic cholecystitis and 80 healthy control subjects were determined, differences of the above average values between the patient group and the control group and differences of the average values between preoperative and postoperative patients were analyzed and compared, linear regression and correlation of the disease course with the above determination values as well as the stepwise regression and correlation of the course with the values were analyzed. RESULTS Compared with the control group, the average values of P-NO, P-LPO, E-LPO were significantly increased ( P < 0.01 ), and of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT and E-GSH-Px decreased ( P < O. 01 ) in the patient group. The analysis of the linear regression and correlation showed that with prolonging of the course, the values of P-NO, P-LPO and E-LPO in the patients were gradually ascended and the values of P-VC, P-VE, P-β-CAR, E-SOD, E-CAT and E-GSH-Px descended (P < 0. 01 ). The analysis of the stepwise regression and correlation indicated that the correlation of the course with P-NO, P-VE and P-β-CAR values was the closest. Compared with the preoperative patients, the average values of PNO, P-LPO and E-LPO were significantly decreased (P < 0.01 ) and the average values of PVC, E-SOD, E-CAT and E-GSH-Px in postoperative patients increased ( P < 0.01) in postoperative patients. But there was no significant difference in the average values of P-VE, P-W-CAR preoperative and postoperative patients. CONCLUSION Chronic cholecystitis could induce the increase of nitric oxide, oxidation, peroxidation and lipoperoxidation.     

餐饮、公共场所从业人员乙肝血清标志物常见模式研究

目的了解我国城市餐饮从业人员HBV-M常见模式构成,为制定防制策略提供依据。方法HBsAg初筛阳性者采用酶联免疫吸附方法检测HBV-M,应用文献系统综述方法分析模式构成。结果2000～2007年11城市体检722 909人,HBsAg阳性率为6.00%。阳性率最高为沿海地区,其次为南方城市和北方城市,城市间差异极显著。HBsAg阳性率分布南方多于北方,东部多于西部。抗-HBs阳性率明显低于全国调查水平,最高为北方城市,其次为南方城市和沿海地区,地区间比较均有显著差异。HBV-M不同地区间差异显著(P≤0.001)。差异最大的为沿海城市,其次为南方城市和北方城市。结论首次揭示城市餐饮从业人员HBsAg阳性率为6.00%和感染模式构成,提示应强化乙肝疫苗接种,对控制传播、制定防制策略有重要意义。     

罗红霉素颗粒的人体生物等效性研究

目的 评价国内不同厂家罗红霉素颗粒的相对生物利用度和生物等效性.方法 18名男性健康受试者采用随机、自身对照、交叉法单剂量口服两个不同厂家的罗红霉素颗粒后,采用微生物法测定血浆中罗红霉素浓度.结果 单剂量口服300mg罗红霉素颗粒受试和参比制剂后的达峰时间Tmax分别为(1.20±5.50)h和(1.70±0.50)h;峰值血药浓度Cmax分别(6.84±2.57)h;药时曲线下面积AUC(0→48)分别为94.03±15.85)μg·h·mL-1和(100.25±15.27)μg·h·mL-1.两种片剂所有的药物动力学参数均无显著性差异(P＞0.05),受试制剂的相对生物利用度F为(95.0±16.2)%.结论 两种制剂生物等效.     

热性惊厥与注意缺陷多动障碍关系探讨

目的 探讨热性惊厥（FC）与注意缺陷多动障碍（ADHD）的关系。方法 由小儿神经专科医师对172例FC进行5～10年远期随访,Conner’s简明症状问卷等方法对患儿进行测试。结果 有FC史小儿ADHD患病率为23.8%（41/72）,与无FC史的小儿ADHD患病率5.1%（14/273）相比,差异有非常显著性（P﹤0.01）。另外FC的发作次数﹤4次和≥4次,持续时间﹤30min和≥30min ADHD患病率相比均有非常显著差异（P<0.01）。结论 本资料提示FC多次、长时间发作可能是小儿ADHD发生原因之一,小儿反复性热性惊厥,有复发或癫痫危险因素宜用药物预防。