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Kerttula AM Lyytikäinen O Vuopio-Varkila J Ibrahem S Agthe N Broas M Jägerroos H Virolainen A 《Journal of clinical microbiology》2005,43(12):6161-6163
Our point-prevalence survey followed an outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in a long-term care facility and identified five MRSA strains, of which two possessed an outbreak genotype not encountered previously and three had another profile. All of them possessed SCCmec type V. Six methicillin-sensitive S. aureus strains were genotypically related to the epidemic strains. 相似文献
3.
Bakhtin's Philosophy and Medical Practice — Toward a Semiotic Theory of Doctor — patient Interaction
Puustinen R 《Medicine, health care, and philosophy》1999,2(3):275-281
Doctor-patient interaction has gained increasing attention among sociologists and linguists during the last few decades. The
problem with the studies performed so far, however, has been a lack of a theoretical framework which could bring together
the various phenomena observed within medical consultations. Mikhail Bakhtin's philosophy of language offers us tools for
studying medical practice as socio-cultural semiotic phenomenon. Applying Bakhtin's ideas of polyphonic, context-dependent
and open-ended nature of human communication opens the possibilities to develop prevailing theoretical and empirical approaches
to the study of medical consultations.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
4.
Shalaila S. Haas Linda A. Antonucci Julian Wenzel Anne Ruef Bruno Biagianti Marco Paolini Boris-Stephan Rauchmann Johanna Weiske Joseph Kambeitz Stefan Borgwardt Paolo Brambilla Eva Meisenzahl Raimo K. R. Salokangas Rachel Upthegrove Stephen J. Wood Nikolaos Koutsouleris Lana Kambeitz-Ilankovic 《Neuropsychopharmacology》2021,46(4):828
Two decades of studies suggest that computerized cognitive training (CCT) has an effect on cognitive improvement and the restoration of brain activity. Nevertheless, individual response to CCT remains heterogenous, and the predictive potential of neuroimaging in gauging response to CCT remains unknown. We employed multivariate pattern analysis (MVPA) on whole-brain resting-state functional connectivity (rsFC) to (neuro)monitor clinical outcome defined as psychosis-likeness change after 10-hours of CCT in recent onset psychosis (ROP) patients. Additionally, we investigated if sensory processing (SP) change during CCT is associated with individual psychosis-likeness change and cognitive gains after CCT. 26 ROP patients were divided into maintainers and improvers based on their SP change during CCT. A support vector machine (SVM) classifier separating 56 healthy controls (HC) from 35 ROP patients using rsFC (balanced accuracy of 65.5%, P < 0.01) was built in an independent sample to create a naturalistic model representing the HC-ROP hyperplane. This model was out-of-sample cross-validated in the ROP patients from the CCT trial to assess associations between rsFC pattern change, cognitive gains and SP during CCT. Patients with intact SP threshold at baseline showed improved attention despite psychosis status on the SVM hyperplane at follow-up (p < 0.05). Contrarily, the attentional gains occurred in the ROP patients who showed impaired SP at baseline only if rsfMRI diagnosis status shifted to the healthy-like side of the SVM continuum. Our results reveal the utility of MVPA for elucidating treatment response neuromarkers based on rsFC-SP change and pave the road to more personalized interventions.Subject terms: Predictive markers, Psychosis 相似文献
5.
Kaija Komulainen DDS Pekka Ylöstalo DDS PhD Anna‐Maija Syrjälä DDS PhD Piia Ruoppi DDS Matti Knuuttila DDS PhD Raimo Sulkava MD PhD Sirpa Hartikainen MD PhD 《Special care in dentistry》2014,34(1):19-26
The aim was to study the determinants of preventive oral health care need among community‐dwelling old people. The study population consisted of 165 participants, a subpopulation in the Geriatric Multidisciplinary Strategy for Good Care of Elderly People (GeMS) study. Fifty‐five percent of the edentate participants with full dentures and 82% of the dentate had a need for preventive oral health care. In the total study population, the need for preventive care was associated with co‐morbidity (measured by means of the Modified Functional Co‐morbidity Index) odds ratios (OR) 1.2 (confidence intervals [CI] 1.0–1.5), being pre‐frail or frail, OR 2.5 (CI 1.2–5.1), presence of natural teeth, OR 4.8 (CI 2.2–10.4), and among dentate participants, the use of a removable partial denture, OR 12.8 (CI 1.4–114.4). Primary care clinicians should be aware of the high need for preventive care and the importance of nonoral conditions as determinants of preventive oral health care need. 相似文献
6.
Giacobbe Chiara Raimo Simona Cropano Maria Santangelo Gabriella 《Brain imaging and behavior》2022,16(5):2353-2374
Brain Imaging and Behavior - The neural correlates of action language processing are still debated within embodied cognition research and little is known about the flexible involvement of... 相似文献
7.
S. Wayne Miles Janie Sheridan Bruce Russell Rob Kydd Amanda Wheeler Carina Walters Greg Gamble Peta Hardley Maree Jensen Kimmo Kuoppasalmi Pekka Tuomola Jaana Föhr Outi Kuikanmäki Helena Vorma Raimo Salokangas Antti Mikkonen Mika Kallio Jussi Kauhanen Vesa Kiviniemi Jari Tiihonen 《Addiction (Abingdon, England)》2013,108(7):1279-1286
8.
Anne-Marie Kerttula Outi Lyytikäinen Minna Kardén-Lilja Salha Ibrahem Saara Salmenlinna Anni Virolainen Jaana Vuopio-Varkila 《BMC infectious diseases》2007,7(1):94
Background
In Finland, the annual number of MRSA notifications to the National Infectious Disease Register (NIDR) has constantly increased since 1995, and molecular typing has revealed numerous outbreak isolates of MRSA. We analyzed the data on MRSA notifications of the NIDR, and MRSA isolates were identified mainly by pulsed-field gel electrophoresis (PFGE) at the National Reference Laboratory (NRL) in Finland during 1997–2004. One isolate representative of each major PFGE type was further characterized by multilocus sequence (MLST)-, staphylococcal cassette chromosome mec (SCCmec)-, and Panton-Valentine leukocidin (PVL)-typing. 相似文献9.
Concentration distributions for 183 drugs and metabolites frequently found in post‐mortem (PM) femoral venous blood were statistically characterized based on an extensive database of 122 234 autopsy cases investigated during an 18‐year period in a centralized laboratory. The cases represented all causes of death, with fatal drug poisonings accounting for 8%. The proportion of males was 74% with a median age of 58 years compared with 26% females with a median age of 64 years. In 36% of these cases, blood alcohol concentration was higher than or equal to 0.2‰, the median being 1.6‰. The mean, median, and upper percentile (90th, 95th, 97.5th) drug concentrations were established, as the median PM concentrations give an idea of the “normal” PM concentration level, and the upper percentile concentrations indicate possible overdose levels. A correspondence was found between subsets of the present and the previously published PM drug concentrations from another laboratory that grouped cases according to the cause of death. Our results add to the knowledge for evidence‐based interpretation of drug‐related deaths. 相似文献
10.
Utriainen P Laakso S Jääskeläinen J Voutilainen R 《Metabolism: clinical and experimental》2012,61(9):1215-1219
Premature adrenarche (PA) refers to an earlier than normal increase in adrenocortical androgen production. The pathogenesis of PA remains largely unknown. We hypothesized that common polymorphisms at P450 oxidoreductase (POR), steroid sulfotransferase (SULT2A1), or 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1) genes could contribute to the polygenic pathogenesis of PA. We performed a case–control study on the polymorphisms rs1057868 at POR, rs182420 at SULT2A1, and rs12086634 at HSD11B1. The study cohort comprised 73 prepubertal children with PA (defined by clinical signs) and 97 age- and gender-matched healthy controls from a Finnish Caucasian population. Genotype distributions and clinical and metabolic phenotypes were determined. The genotype distributions of the polymorphisms were similar between the study groups. No variant was associated with alterations in serum adrenal steroid concentrations. The minor C variant at SULT2A1 was associated with higher serum sex hormone binding globulin (SHBG) concentrations (T/T, n = 64 vs T/C&;C/C, n = 33; mean 94 vs 116 nmol/L; P = .001) and a trend for lower dehydroepiandrosterone sulfate/dehydroepiandrosterone ratios in the controls (P = .06), and with higher plasma total cholesterol concentrations in the PA subjects (T/T, n = 42 vs T/C&;C/C, n = 31; 4.0 vs 4.6 mmol/L; P < .001). The minor G variant at HSD11B1 was associated with lower plasma triglyceride concentration in the controls (T/T, n = 65 vs T/G&;G/G, n = 32; 0.61 vs 0.49 mmol/L; P = .013). Common polymorphisms at POR, SULT2A1 or HSD11B1 were not associated with PA in a Finnish Caucasian population. 相似文献