全文获取类型
收费全文 | 377篇 |
免费 | 51篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 9篇 |
妇产科学 | 16篇 |
基础医学 | 39篇 |
口腔科学 | 9篇 |
临床医学 | 48篇 |
内科学 | 78篇 |
皮肤病学 | 11篇 |
神经病学 | 20篇 |
特种医学 | 9篇 |
外科学 | 46篇 |
综合类 | 5篇 |
预防医学 | 43篇 |
眼科学 | 11篇 |
药学 | 47篇 |
中国医学 | 12篇 |
肿瘤学 | 26篇 |
出版年
2024年 | 1篇 |
2023年 | 11篇 |
2022年 | 11篇 |
2021年 | 23篇 |
2020年 | 18篇 |
2019年 | 15篇 |
2018年 | 31篇 |
2017年 | 17篇 |
2016年 | 18篇 |
2015年 | 20篇 |
2014年 | 20篇 |
2013年 | 38篇 |
2012年 | 31篇 |
2011年 | 36篇 |
2010年 | 20篇 |
2009年 | 16篇 |
2008年 | 16篇 |
2007年 | 20篇 |
2006年 | 14篇 |
2005年 | 10篇 |
2004年 | 13篇 |
2003年 | 9篇 |
2002年 | 1篇 |
2001年 | 4篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1979年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有430条查询结果,搜索用时 93 毫秒
1.
Jalaei Nobari Hossein Rashedi Jalil Mahdavi Poor Behroz Asgharzadeh Mohammad 《Archives of sexual behavior》2022,51(7):3219-3220
Archives of Sexual Behavior - 相似文献
2.
Adaptation and evaluation of the Family Involvement and Alienation Questionnaire for use in the care of older people,psychiatric care,palliative care and diabetes care
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
3.
4.
Granulocyte‐macrophage colony‐stimulating factor,a potent adjuvant for polarization to Th‐17 pattern: an experience on HIV‐1 vaccine model
下载免费PDF全文
![点击此处可从《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mehdi Mahdavi Amir Hossein Tajik Massoumeh Ebtekar Roghieh Rahimi Mohammad Mehdi Adibzadeh Hamid Reza Moozarmpour Mohammad Sadegh Beikverdi Soophie Olfat Zuhair Mohammad Hassan Mohammad Choopani Morteza Kameli Christine Hartoonian 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2017,125(6):596-603
Cytokines are mediators for polarization of immune response in vaccines. Studies show that co‐immunization of DNA vaccines with granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) can increase immune responses. Here, experimental mice were immunized with HIV‐1tat/pol/gag/env DNA vaccine with GM‐CSF and boosted with recombinant vaccine. Lymphocyte proliferation with Brdu and CTL activity, IL‐4, IFN‐γ, IL‐17 cytokines, total antibody, and IgG1 and IgG2a isotypes were assessed with ELISA. Results show that GM‐CSF as adjuvant in DNA immunization significantly increased lymphocyte proliferation and IFN‐γ cytokines, but CTL response was tiny increased. Also GM‐CSF as adjuvant decreased IL‐4 cytokine vs mere vaccine group. IL‐17 in the group that immunized with mixture of DNA vaccine/GM‐CSF was significantly increased vs DNA vaccine group. Result of total antibody shows that GM‐CSF increased antibody response in which both IgG1 and IgG2a increased. Overall, results confirmed the beneficial effect of GM‐CSF as adjuvant to increase vaccine immunogenicity. The hallmark result of this study was to increase IL‐17 cytokine with DNA vaccine/GM‐CSF immunized group. This study for the first time provides the evidence of the potency of GM‐CSF in the induction of IL‐17 in response to a vaccine, which is important for control of infection such as HIV‐1. 相似文献
5.
6.
7.
The concept of food addiction (FA) is a potentially important contributing factor to the development of obesity in the general population; however, little is known about the hormonal and dietary differences between obesity with and without FA. Therefore, the aim of our study was to explore potential biomarkers, including various hormones and neuropeptides, which regulate appetite and metabolism, and dietary components that could potentially differentiate obesity with and without FA. Of the 737 adults recruited from the general Newfoundland population, 58 food-addicted and non-food-addicted overweight/obese individuals (FAO, NFO) matched for age, sex, BMI and physical activity were selected. A total of 34 neuropeptides, gut hormones, pituitary polypeptide hormones and adipokines were measured in fasting serum. We found that the FAO group had lower levels of TSH, TNF-α and amylin, but higher levels of prolactin, as compared to NFO group. The total calorie intake (per kg body weight), the dietary intake of fat (per g/kg body weight, per BMI and per percentage of trunk fat) and the percent calorie intake from fat and carbohydrates (g/kg) was higher in the FAO group compared to the NFO group. The FAO subjects consumed more sugar, minerals (including sodium, potassium, calcium and selenium), fat and its components (such as saturated, monounsaturated and trans fat), omega 3 and 6, vitamin D and gamma-tocopherol compared to the NFO group. To our knowledge, this is the first study indicating possible differences in hormonal levels and micro-nutrient intakes between obese individuals classified with and without food addiction. The findings provide insights into the mechanisms by which FA could contribute to obesity. 相似文献
8.
Esalatmanesh Kamal Loghman Amirhossein Esalatmanesh Roozbeh Soleimani Zahra Khabbazi Alireza Mahdavi Aida Malek Mousavi Seyed Gholam Abbas 《Clinical rheumatology》2021,40(9):3591-3597
Clinical Rheumatology - Considering the pathologic significance of inflammation and oxidative stress in rheumatoid arthritis (RA) as well as the antioxidant, anti-inflammatory and hypolipidemic... 相似文献
9.
Malek Mahdavi Aida Khalili Afshin Alihosseini Samin Jaberinezhad Mehran Esalatmanesh Kamal Hajialilo Mehrzad Seyedmardani Seyedmostafa Khabbazi Alireza 《Clinical rheumatology》2021,40(10):3941-3949
Clinical Rheumatology - Adult-onset Still’s disease (AOSD) characterized by a high spiking fever, skin rash, arthritis, and leukocytosis. The aim of the present study was considering the... 相似文献
10.