全文获取类型
收费全文 | 985篇 |
免费 | 43篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 15篇 |
妇产科学 | 16篇 |
基础医学 | 99篇 |
口腔科学 | 9篇 |
临床医学 | 44篇 |
内科学 | 293篇 |
皮肤病学 | 6篇 |
神经病学 | 57篇 |
特种医学 | 24篇 |
外科学 | 284篇 |
综合类 | 5篇 |
预防医学 | 31篇 |
眼科学 | 19篇 |
药学 | 34篇 |
中国医学 | 2篇 |
肿瘤学 | 93篇 |
出版年
2023年 | 5篇 |
2022年 | 10篇 |
2021年 | 34篇 |
2020年 | 14篇 |
2019年 | 34篇 |
2018年 | 23篇 |
2017年 | 27篇 |
2016年 | 25篇 |
2015年 | 23篇 |
2014年 | 39篇 |
2013年 | 48篇 |
2012年 | 77篇 |
2011年 | 62篇 |
2010年 | 26篇 |
2009年 | 27篇 |
2008年 | 42篇 |
2007年 | 46篇 |
2006年 | 35篇 |
2005年 | 39篇 |
2004年 | 49篇 |
2003年 | 40篇 |
2002年 | 38篇 |
2001年 | 30篇 |
2000年 | 22篇 |
1999年 | 27篇 |
1998年 | 6篇 |
1997年 | 8篇 |
1996年 | 8篇 |
1995年 | 12篇 |
1994年 | 9篇 |
1993年 | 5篇 |
1992年 | 11篇 |
1991年 | 13篇 |
1990年 | 12篇 |
1989年 | 9篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1985年 | 5篇 |
1984年 | 9篇 |
1983年 | 4篇 |
1980年 | 5篇 |
1979年 | 16篇 |
1977年 | 6篇 |
1975年 | 6篇 |
1973年 | 4篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1968年 | 4篇 |
1967年 | 3篇 |
排序方式: 共有1034条查询结果,搜索用时 15 毫秒
1.
Endoscopic endonasal removal of an intra-suprasellar Rathke's cleft cyst: case report and surgical considerations. 总被引:3,自引:0,他引:3
A Alfieri R Schettino A Tarfani O Bonzi G A Rossi L Monolo 《Minimally invasive neurosurgery》2002,45(1):47-51
An endoscopic endonasal approach was performed to remove an intra-suprasellar Rathke's cleft cyst. Rathke's cleft cyst are benign lesions, rarely diagnosed because they are often asymptomatic. To the best of our knowledge, at least 475 cases of Rathke's cleft cysts have been reported. They seem to arise from remnants of Rathke's pouch, an invagination of the stomodeum. A 52-year-old woman, complaining of bilateral frontal headaches, was operated on by using an endoscopic endonasal approach, for an intra-suprasellar tumor. The pre-operative diagnosis was non-functioning pituitary adenoma. Intra-operatively a creamy-coloured viscous tissue was found. After the removal of the cyst contents and of the capsule, the suprasellar structures were seen well. The chiasmatic cistern, the chiasm, the pituitary stalk and the pituitary gland were visualized with 0 and 30 degree endoscopes. The pathological findings showed a well-differentiated cuboidal epithelium. The diagnosis was Rathke's cleft cyst. No post-operative complications were observed. The endoscopic technique was particularly suitable in this case, both for the Rathke's cleft features and for an excellent outcome. The Rathke's cleft cyst was easily removed by suction and the cyst wall was entirely removed with curettes and pituitary punches. The hypophysis was distinguished from the cyst and was preserved. The surgical manoeuvres were all done under direct visual control. The absence of nasal packing and of breathing difficulties made comfortable the post-operative outcome. Thus, the endoscopic endonasal approach can be considered the favourite technique in case of either intra- and/or suprasellar Rathke's cleft cysts. 相似文献
2.
C. Shustik B. M. Jamison C. Alfieri S. Scherer R. Loertscher 《British journal of haematology》1995,91(1):167-168
Summary Allotransplantation of solid organs transfers passenger leucocytes which may give rise to a state of persistent microchimaerism. In this report we describe the case of a patient who developed a solitary plasmacytoma in a transplanted kidney more than 10 years after allografting. The diagnosis was established on the basis of the presence of a monoclonal IgG kappa peak in the serum, and light chain proteinuria, the plasmacytoid features of tumour cells including cell surface expression of IgG, kappa light chains, CD20, CD38 and CD56, the absence of lytic bone lesions and a normal bone marrow biopsy, and the disappearance of the monoclonal IgG peak after graft nephrectomy. A donor origin of the tumour was established by HLA DNA typing of tumour, tumour-free kidney tissue, and peripheral blood leucocytes, respectively. 相似文献
3.
4.
Shahriar Yazdanfar Gary S. Ledley Anthony Alfieri Clifford Strauss Morris N. Kotler 《Catheterization and cardiovascular interventions》1993,28(1):72-75
Percutaneous transluminal coronary angioplasty (PTCA) of heavily calcified rigid coronary arteries has decreased success and increased complication rates. Three cases are presented describing a new technique for the dilatation of severely calcified coronary arteries that were not dilatable by conventional angioplasty methods. This technique involves the use of a balloon dilatation catheter system parallel to a guide wire. © 1993 Wiley-Liss, Inc. 相似文献
5.
To test the role of serotonin in chemotherapy-induced nausea and emesis, ten cancer patients were pretreated with the serotonin synthesis inhibitor para-chlorophenylalanine (PCPA). PCPA (2 g 8 hourly for 2 or 3 days prior to cisplatin) reduced the spontaneous urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), inhibited the increase in urinary 5-HIAA induced by cisplatin and markedly attenuated the acute period of nausea and vomiting associated with the cytotoxic drug. These results indicate that gastrointestinal serotonin mediates cisplatin-induced emesis and that the amount of serotonin released by cisplatin is a major factor in determining the severity of the acute period of emesis experienced by the patient. 相似文献
6.
The research was designed to investigate the moderating effect of some personality traits on subjective distress caused by daily hassles. The traits were internal locus of control, repression, ego strength, and barrier (as studied and defined by S. Fisher). The last two variables were negatively correlated both with the somatic and emotional distress indications and with the frequency of hassles reportED; internal locus of control showed an inverse relationship only with frequency of hassles. The hypothesis is formulated that ego strength and barrier are personality factors influencing not only the outcomes of coping (ie the stress response), but also event appraisal. 相似文献
7.
L E Nicolle L Buffet N Alfieri R Tate 《Infection control and hospital epidemiology》1988,9(12):553-558
In a one-year retrospective review, 138 symptomatic infections were identified in 145 admissions to a rehabilitation unit. One hundred twenty-six (91%) infections were either urinary or skin and soft tissue infections. The daily incidence of infection increased with increasing numbers of infections for infected patients. Patient factors associated with infection included male sex, young age, spinal cord injury, admission for management of decubitus ulcers or urinary infection, history of urinary infection, urologic interventions or skin breakdown, and bladder and bowel incontinence. All patients with a history of chronic urinary infection or skin breakdown developed infection. In a logistic regression model, factors that were independently associated with risk of infection in the remaining patients included sex, incontinence, chronic neurologic disease, and prior urologic interventions. This review suggests rehabilitation patients are at high risk of acquiring nosocomial infection. The subgroup of patients with the highest risk of infection are identifiable by specific characteristics. 相似文献
8.
In vivo multiple-mouse imaging at 1.5 T. 总被引:3,自引:0,他引:3
S Xu T P F Gade C Matei K Zakian A A Alfieri X Hu E C Holland S Soghomonian J Tjuvajev D Ballon J A Koutcher 《Magnetic resonance in medicine》2003,49(3):551-557
A multiple-mouse solenoidal MR coil was developed for in vivo imaging of up to 13 mice simultaneously to screen for tumors on a 1.5 T clinical scanner. For the coil to be effective as a screening tool, it should permit acquisition of MRIs in which orthotopic tumors with diameters >2 mm are detectable in a reasonable period of time (<1 hr magnet time) and their sizes accurately measured. Using a spin echo sequence, we demonstrated that this coil provides sufficient sensitivity for moderately high resolution images (156-176 microm in plane-resolution, 1.5 mm slice thickness). This spatial resolution permitted detection of primary brain tumors in transgenic/knockout mice and orthotopic xenografts. Brain tumor size as measured by MRI was correlated with size measured by histopathology (P < 0.001). Metastatic tumors in the mouse lung were also successfully imaged in a screening setting. The multiple mouse coil is simple in construction and may be implemented without any significant modification to the hardware or software on a clinical scanner. 相似文献
9.
Chiurillo MA Crisante G Rojas A Peralta A Dias M Guevara P Añez N Ramírez JL 《Clinical and diagnostic laboratory immunology》2003,10(5):775-779
We used the species specificity and repetitious nature of subtelomeric kinetoplastida sequences to generate a duplex PCR assay for the simultaneous detection of Trypanosoma cruzi and Trypanosoma rangeli in experimentally and naturally infected triatomine (Reduviid) bugs and in infected human subjects. The assay was species specific and was capable of detecting 1/20th of T. cruzi and 1/4th of T. rangeli cell equivalents without complementary hybridization. In addition, the PCR-based assay was robust enough for direct application to difficult biological samples such as Reduviid feces or guts and was capable of recognizing all T. cruzi and T. rangeli strains and lineages. Because the assay primers amplify entirely different target sequences, no reaction interference was observed, facilitating future adaptation of this assay to an automated format. 相似文献
10.
Eugenio I. Vivas Andreina Liendo Karl Dawidowicz Toms Istúriz 《Journal of basic microbiology》1994,34(2):117-122
It is known that two gluconokinases are inducibly expressed during the utilization of gluconate by E. coli. One is thermoresistant (activity stable for 3 h at 30 °C) and the other thermosensitive (losses 75% or more of its activity under the above conditions). The thermoresistant gluconokinase (EC 2.7.1.12) was isolated, purified and characterized for the first time from the E. coli mutant Ca26, a K12 derivative which lacks the thermosensitive activity. The enzyme was purified 43 fold with a recovery of 11%. The Mr of the enzyme was 100 kDa with three equal subunits of approximately 29.5 kDa. The enzyme exhibited Michaelis-Menten kinetics and the Km values for gluconate and ATP were 0.02 mM and 0.045 mM respectively. 相似文献