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广西常见突发化学中毒事件应急救治综合疗法的研究 总被引:4,自引:1,他引:3
葛宪民 苏素花 李丹亚 韦建华 梁启荣 李勇强 陈捷 农康 李航天 覃政活 覃卫平 秦少珍 邵春华 陈克宽 江世强 翟日洪 屈紫清 陈志强 梧永宁 《广西医科大学学报》2007,24(5):669-672
目的:探索更为有效的突发化学中毒事件应急救治技术方案和关键技术,以提高突发化学中毒事件应急救治水平.方法:运用循证医学方法,对过去13年来广西常见突发化学中毒事件进行回顾性调查,总结应急救治所取得的成功经验,优化应急救治技术方案,探索突发化学中毒应急救治新理论、新方法、关键抢救技术.结果:"毒鼠强解毒鸡尾酒疗法"应急救治技术应用于1 133例急性毒鼠强中毒患者的抢救,无一例死亡;"非特异综合解毒急救疗法"抢救了7种急性化学中毒患者372例,全部获得抢救成功;"特异性解毒急救疗法"抢救3种急性化学中毒患者101例,全部获得抢救成功.结论:本研究总结出的3种应急救治疗方法应用于1 606例急性化学中毒患者的抢救,证明可有效降低化学中毒患者病死率. 相似文献
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目的 了解还原型谷胱甘肽滴眼液联合黄芪注射液治疗职业性三硝基甲苯(TNT)白内障的临床疗效.方法 对45例职业性TNT白内障治疗前后进行疗效观察并对比分析.结果 用药3个疗程后检查,视力有所提高(73.33%),其中E字母增进≥1行有56.67%、增进<1行有16.67%,显示较好的效果.治疗后眼部血流动力学明显改善,与治疗前比较,差异有统计学意义(P<0.05).6%眼晶状体混浊形态有不同程度改善.结论 治疗职业性TNT白内障必须着重改善眼周围微循环障碍,同时以抗氧化清除氧自由基联合治疗,才能提高疗效. 相似文献
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脂肪肝是指脂肪在肝细胞内过度沉积所引起的一种疾病,脂肪肝临床上没有特异性表现,少数仅有右上腹不适感,易被忽视。随着人们生活水平的提高,膳食结构及生活方式的变化,脂肪肝呈逐年增加的趋势,应引起足够的重视,普通人群脂肪肝的患病率为5.2%~11.4%,并有明显低龄化趋向。焦化作业人员由于在工作中接触焦化逸散物(COE),使这一特殊职业人群脂肪肝的检出率高于普通人群,为进一步证实焦化作业人员脂肪肝的患病情况与COE的关系,2008-2009年,我们对广西某焦化厂工人的B超检查资料进行了统计分析,现报道如下。 相似文献
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Objective MRI and MR hydrogen proton spectroscopy (1H-MRS) were used to detect the abnormal signal and alteration of metabolites, in order to explore the efficacy of these method in evaluating the damages of central nervous system (CNS) induced by occupational manganese exposure.Methods Eighteen workers exposed to manganese without any manganism symptoms, 12 workers with slightly chronic manganese poisoning, and 19 healthy workers were scanned using routine MRI sequence and 1H-MRS.The blood manganese concentration was also collected for each subject.On cerebral axial T1 WI,the signal intensities of ipsilateral globus pallidus and frontal white matter were measured in the visually brightest area (try to select the signal homogeneous region), and the globus pallidus index (PI) was then calculated.The 1H-MRS data was calculated to get the values of the peak height of N-acetylaspartate (NAA), choline (Cho), inositol (mI) and creatine (Cr) and the ratios of NAA/Cr, Cho/Cr, and mL/Cr were also calculated.One way ANOVA was used to compare the values of PI, NAA/Cr, Cho/Cr, mI/Cr and MnB among the three groups, and the correlations between PI and the time span of manganese exposure or blood manganese concentration were analyzed by Pearson correlation analysis.Eight workers exposed to manganese were followed up one year, and their PI , NAA/Cr before and after follow-up were compared by t test.Results Fourteen of 18 cases exposed to manganese without any manganism symptoms showed symmetrically high intensity signal on T1 WI, while the T2 WI were normal.No high signal intensity was observed on T1WI in any of the healthy workers or manganese poisoning workers.We found that the average PI in manganese exposed group (1.16 ±0.09) was significantly higher (F =24.79 ,P =0.O00)than those of the poisoning ( 1.05 ± 0.07 ) and control groups ( 1.01 ± 0.05 ).The blood manganese concentration in manganese exposed group, the poisoning group and the control group were (0.051 ±0.024), (0.047 ±0.018 ), ( 0.043 ± 0.020 ) μg/ml respectively, which was not significantly different ( F = O.623, P =0.541 ) and did not exceed the upper limit of normal reference value ( < 0.10 μg/ml ).There was a significantly correlation between PI and the time span of manganese exposure ( r = 0.67, P = 0.002 ),however, there was no correlation between PI and blood manganese concentration ( r = 0.20, P = 0.427 ).Furthermore, the NAA/Cr ratio decreased variously in the manganese poisoning group ( 1.22 ± 0.07 ) which was significantly lower( F = 4.120, P = 0.023 ) than those of the poisoning( 1.33 ± 0.13 ) and control groups ( 1.31 ±0.13).No statistical significanees were found in the ratios of Cho/Cr and mI/Cr among these three groups(P>0.05).No obvious changes of the PI and NAA/Cr were found in the 8 manganese exposed workers after 1 year follow-up.Conclusion Manganese exposure could lead to the high intensity signal on T1 WI, therefore the increased PI may be the biomarkers of central nerve system damages caused by the occupational manganese exposure. 相似文献
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Objective MRI and MR hydrogen proton spectroscopy (1H-MRS) were used to detect the abnormal signal and alteration of metabolites, in order to explore the efficacy of these method in evaluating the damages of central nervous system (CNS) induced by occupational manganese exposure.Methods Eighteen workers exposed to manganese without any manganism symptoms, 12 workers with slightly chronic manganese poisoning, and 19 healthy workers were scanned using routine MRI sequence and 1H-MRS.The blood manganese concentration was also collected for each subject.On cerebral axial T1 WI,the signal intensities of ipsilateral globus pallidus and frontal white matter were measured in the visually brightest area (try to select the signal homogeneous region), and the globus pallidus index (PI) was then calculated.The 1H-MRS data was calculated to get the values of the peak height of N-acetylaspartate (NAA), choline (Cho), inositol (mI) and creatine (Cr) and the ratios of NAA/Cr, Cho/Cr, and mL/Cr were also calculated.One way ANOVA was used to compare the values of PI, NAA/Cr, Cho/Cr, mI/Cr and MnB among the three groups, and the correlations between PI and the time span of manganese exposure or blood manganese concentration were analyzed by Pearson correlation analysis.Eight workers exposed to manganese were followed up one year, and their PI , NAA/Cr before and after follow-up were compared by t test.Results Fourteen of 18 cases exposed to manganese without any manganism symptoms showed symmetrically high intensity signal on T1 WI, while the T2 WI were normal.No high signal intensity was observed on T1WI in any of the healthy workers or manganese poisoning workers.We found that the average PI in manganese exposed group (1.16 ±0.09) was significantly higher (F =24.79 ,P =0.O00)than those of the poisoning ( 1.05 ± 0.07 ) and control groups ( 1.01 ± 0.05 ).The blood manganese concentration in manganese exposed group, the poisoning group and the control group were (0.051 ±0.024), (0.047 ±0.018 ), ( 0.043 ± 0.020 ) μg/ml respectively, which was not significantly different ( F = O.623, P =0.541 ) and did not exceed the upper limit of normal reference value ( < 0.10 μg/ml ).There was a significantly correlation between PI and the time span of manganese exposure ( r = 0.67, P = 0.002 ),however, there was no correlation between PI and blood manganese concentration ( r = 0.20, P = 0.427 ).Furthermore, the NAA/Cr ratio decreased variously in the manganese poisoning group ( 1.22 ± 0.07 ) which was significantly lower( F = 4.120, P = 0.023 ) than those of the poisoning( 1.33 ± 0.13 ) and control groups ( 1.31 ±0.13).No statistical significanees were found in the ratios of Cho/Cr and mI/Cr among these three groups(P>0.05).No obvious changes of the PI and NAA/Cr were found in the 8 manganese exposed workers after 1 year follow-up.Conclusion Manganese exposure could lead to the high intensity signal on T1 WI, therefore the increased PI may be the biomarkers of central nerve system damages caused by the occupational manganese exposure. 相似文献
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通过对某厂50例三硝基甲苯(TNT)作业人员眼晶状体混浊的临床观察,了解其发病规律,对其住院的临床资料进行分级诊断.结果 显示,所有病例均诊断为职业性三硝基甲苯白内障,其中一期白内障30例,二期白内障17例,三期白内障3例,肝脏、血液、神经系统改变不明显.提示,眼晶状体混浊是TNT作业工人最常见、出现最早的和最具特异性... 相似文献
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在200例尘肺患者中检出85例出现胸膜增厚,其中31例为弥漫性胸膜增厚,54例局限性胸膜增厚,尘肺病胸膜增厚的发生率为42.50%。提示随着尘肺病病期的进展,尘肺并发胸膜增厚呈升高趋势。 更多还原 相似文献