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目的 探讨新生儿溶血病凝血功能的变化及其临床意义.方法 以新生儿溶血病(溶血病组)、非溶血性高胆红素血症(非溶血病组)患儿各60例为研究对象,同期出生的60例正常足月儿为对照组.测定各组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血小板计数.结果 溶血病组PT、APTT明显高于非溶血病组[(28.79±4.21)s比(18.98±241)s和(58.52±313)s比(47.26±5.81)s],且两组明显高于对照组[(13.81±1.83)s和(38.10±3.00)s],差异有统计学意义(P<0.05),而血小板计数比较差异无统计学意义(P>0.05).结论 新生儿溶血病有出血倾向,与血小板计数无关,而与PT、APTT延长有关,溶血程度越重,PT、APTT升高越明显.PT、APTT可作为新生儿溶血病患儿凝血功能检测的指标和疗效评价指标.Abstract: Objective To investigate the clinical significance and coagulation function changes in newborn hemolytic disease. Method The newborn hemolytic disease ( 60 cases, hemolytic disease group ), non-hemolytic hyperbilirubinemia (60 cases, non-hemolytic hyperbilirubinemia group) and normal newborn (60 cases,control group) were selected as the study subjects, the prothrombin time (PT) and activated partial thromboplastin time (APTT) were measured, and the blood platelet count at the same time was detected. Results PT and APTT in hemolytic disease group were higher than those in non-hemolytic hyperbilirubinemia group[(28.79 ?.21) s vs. (18.98?.41) s and (58.52?.13) s vs. (47.26?.81) s], and they were apparently higher than those in control group [(13.81 ?1.83) s and (38.10 ?3.00) s], the difference had statistic significance (P<0.05). There was no statistic significance to detect the blood platelet count (P> 0.05). Conclusions The newborn hemolytic disease has the bleeding tendency, and the bleeding tendency has no relationship with the quantity of the blood platelet, but relates to the extension of PT and APTT. The more serious the case is, the more obvious the PT and APTT rise. PT and APTT can be as the detection index and evaluating effect of the newborn hemolytic disease coagulation function. 相似文献
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目的探讨新生儿溶血病D-二聚体水平变化及临床意义。方法选取新生儿溶血病患儿60例,按照胆红素水平分为非重度组(34例)和重度组(26例)。同期出生的40例正常足月儿为对照组。检测各组D-二聚体及纤维蛋白原(FIB)水平的变化。结果重度组、非重度组D-二聚体水平[分别为(9.29±11.34)、(0.84±0.77) mg/L]明显高于对照组[(0.45±0.06) mg/L](P< 0.01或<0.05),重度组明显高于非重度组(P<0.01)。各组FIB水平比较差异无统计学意义(P>0.05)。结论重度新生儿溶血病患儿体内存在高凝状态,血浆D-二聚体水平测定对新生儿溶血病患儿的病情判断和治疗有一定的价值。 相似文献
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1临床资料本组160例中,男96例,女64例;年龄最小32岁,最大73岁,平均48.6岁;病程最短20天,最长11年;全部病例均有预部疼痛和(或)肩省麻痛.X线摄片均显示有颈椎病理性改变。2治疗方法三税法即头套牵引、局部敷药、电疗三法联用.①头套牵引:取坐位或卧位,每次牵引30min,力量依个人耐受情况而定。②局部外敷:用自制软坚散结青.药物力芒硝2509,大黄509,乳香309,没药309。共为本,取适量加陈醋调成糊状,摊于双层纱布上,厚约0.2cm~0.3cm,敷于患处。③电疗:选用GZ——IA骨质增生治疗机.将铝板放置于效药的纱布上,开… 相似文献
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目的 探讨半导体激光治疗机对小儿功能性尿频的治疗意义。方法 采用北京三顿电子技术公司研制的SUNDOM-300I型半导体激光治疗机对28例小儿功能性尿频患者进行治疗,依据年龄大小选择功率200~400mw,取相关穴位为靶位,探头距靶位2~3cm,接通电源,每次治疗时间10分钟,每日一次,4天为一疗程。结果 28例中25例治愈,3例有效,随访半年,2例复发。结论 该治疗方法具有操作简便、疗程短、起效快、治愈率高及复发率低等优点,适宜推广应用。 相似文献
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