全文获取类型
收费全文 | 168824篇 |
免费 | 15324篇 |
国内免费 | 9051篇 |
专业分类
耳鼻咽喉 | 1590篇 |
儿科学 | 2776篇 |
妇产科学 | 3187篇 |
基础医学 | 15834篇 |
口腔科学 | 3452篇 |
临床医学 | 21340篇 |
内科学 | 23517篇 |
皮肤病学 | 1996篇 |
神经病学 | 7060篇 |
特种医学 | 5831篇 |
外国民族医学 | 40篇 |
外科学 | 17165篇 |
综合类 | 30695篇 |
现状与发展 | 34篇 |
一般理论 | 18篇 |
预防医学 | 13786篇 |
眼科学 | 3799篇 |
药学 | 18357篇 |
157篇 | |
中国医学 | 10432篇 |
肿瘤学 | 12133篇 |
出版年
2024年 | 447篇 |
2023年 | 2049篇 |
2022年 | 4734篇 |
2021年 | 6888篇 |
2020年 | 5400篇 |
2019年 | 4360篇 |
2018年 | 4694篇 |
2017年 | 4794篇 |
2016年 | 4124篇 |
2015年 | 6670篇 |
2014年 | 8701篇 |
2013年 | 9460篇 |
2012年 | 13880篇 |
2011年 | 14783篇 |
2010年 | 11194篇 |
2009年 | 9413篇 |
2008年 | 11305篇 |
2007年 | 11063篇 |
2006年 | 10284篇 |
2005年 | 8986篇 |
2004年 | 6496篇 |
2003年 | 5656篇 |
2002年 | 4759篇 |
2001年 | 4099篇 |
2000年 | 3617篇 |
1999年 | 2903篇 |
1998年 | 1356篇 |
1997年 | 1278篇 |
1996年 | 1035篇 |
1995年 | 997篇 |
1994年 | 940篇 |
1993年 | 524篇 |
1992年 | 915篇 |
1991年 | 821篇 |
1990年 | 680篇 |
1989年 | 578篇 |
1988年 | 534篇 |
1987年 | 458篇 |
1986年 | 376篇 |
1985年 | 290篇 |
1984年 | 194篇 |
1983年 | 175篇 |
1982年 | 105篇 |
1981年 | 93篇 |
1979年 | 140篇 |
1978年 | 112篇 |
1977年 | 83篇 |
1974年 | 94篇 |
1973年 | 72篇 |
1972年 | 87篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
2.
3.
Zeyu Li Erwei Hao Rui Cao Si Lin Linghui Zou Tianyan Huang Zhengcai Du Xiaotao Hou Jiagang Deng 《中草药(英文版)》2022,14(4):479-493
Zedoary tumeric (Curcumae Rhizoma, Ezhu in Chinese) has a long history of application and has great potential in the treatment of liver cancer. The anti liver cancer effect of zedoary tumeric depends on the combined action of multiple pharmacodynamic substances. In order to clarify the specific mechanism of zedoary tumeric against liver cancer, this paper first analyzes the mechanism of its single pharmacodynamic substance against liver cancer, and then verifies the joint anti liver cancer mechanism of its "pharmacodynamic group". By searching the research on the anti hepatoma effect of active components of zedoary tumeric in recent years, we found that pharmacodynamic substances, including curcumol, zedoarondiol, curcumenol, curzerenone, curdione, curcumin, germacrone, β-elemene, can act on multi-target and multi-channel to play an anti hepatoma role. For example, curcumin can regulate miR, GLO1, CD133, VEGF, YAP, LIN28B, GPR81, HCAR-1, P53 and PI3K/Akt/mTOR, HSP70/TLR4 and NF-κB. Wnt/TGF/EMT, Nrf2/Keap1, JAK/STAT and other pathways play an anti hepatoma role. Network pharmacological analysis showed that the core targets of the "pharmacodynamic group" for anti-life cancer are AKT1, EGFR, MAPK8, etc, and the core pathways are neuroactive live receiver interaction, nitrogen metabolism, HIF-1 signaling pathway, etc. At the same time, by comparing and analyzing the relationship between the specific mechanisms of pharmacodynamic substance and "pharmacodynamic group", it is found that they have great reference significance in target, pathway, biological function, determination of core pharmacodynamic components, formation of core target protein interaction, in-depth research of single pharmacodynamic substance, increasing curative effect and so on. By analyzing the internal mechanism of zedoary tumeric pharmacodynamic substance and "pharmacodynamic group" in the treatment of liver cancer, this paper intends to provide some ideas and references for the deeper pharmacological research of zedoary tumeric and the relationship between pharmacodynamic substance and "pharmacodynamic group". 相似文献
4.
5.
Her-Shyong Shiah Nai-Jung Chiang Chia-Chi Lin Chia-Jui Yen Hui-Jen Tsai Shang-Yin Wu Wu-Chou Su Kwang-Yu Chang Ching-Chiung Wang Jang-Yang Chang Li-Tzong Chen 《The oncologist》2021,26(4):e567-e579
Lessons Learned
- SCB01A is a novel microtubule inhibitor with vascular disrupting activity.
- This first‐in‐human study demonstrated SCB01A safety, pharmacokinetics, and preliminary antitumor activity.
- SCB01A is safe and well tolerated in patients with advanced solid malignancies with manageable neurotoxicity.
6.
Depeng Meng Yichen Meng Bingyang Li Guigang Zeng Bin Zhang Chunlin Hou Haodong Lin Yueping Ouyang 《Journal of orthopaedic science》2021,26(3):409-414
BackgroundComminuted patellar fractures are not rare, and the ideal treatment method remains controversial. The present study was conducted to evaluate effects and compare complications of two different methods used to treat comminuted patellar fractures.MethodsFrom March 2010 to August 2016, 102 cases of 34-C2 or 34-C3 comminuted patellar fractures were treated at our hospital, wherein patients received two different treatments: titanium cable tension band with cerclage method (group A) and intrafragmentary screws with X-shaped plating technique (group B). At follow-ups, articular step-off, range of motion (ROM), Lysholm scores, time of union, and complications were recorded and analyzed. Radiographic and clinical data as well as rate of complications were statistically analyzed.ResultsIn total, 87 patients were included in the final analysis (n = 47 in group A and n = 40 in group B). No significant differences were noted in terms of cost of implant, age, gender, rate of 34-C3 fractures, rate of layered inferior pole fractures, postoperative articular step-off and union time. At 2-year follow-up, average Lysholm scores, ROM and rate of complications were (89.0 ± 4.5), (122°±12°) and (27.7%) in group A and (90.2 ± 3.9), (124°±11°) and (17.5%) in group B, respectively, with no significant differences (p > 0.05). The mean time of surgery in group B was shorter than that in group A with significant difference (p < 0.05).ConclusionsTreatment using the intrafragmentary screws and plate method for amenable comminuted patellar fractures achieved similar complication rate and favorable functional outcomes at the 2-year follow-up, which was comparable to the titanium cable tension band with cerclage method. Thus, the intrafragmentary screws and plate method is effective, safe and convenient for 34-C2/C3 comminuted patellar fractures, especially appropriate for patients with layered fragments. 相似文献
7.
8.
目的比较手术夹闭和介入栓塞治疗颅内未破裂动脉瘤的安全性和有效性。方法计算机检索1990至2018年颅内未破裂动脉瘤的所有临床对照研究。两名研究员分别纳入研究、提取数据、质量评价并应用Rev Man5. 0软件进行数据处理。结果最终纳入21篇文献,病例数109114例。Meta分析结果提示:手术夹闭组动脉瘤闭塞率为88. 2%,平均住院时间7. 7天,均高于介入栓塞组的65. 3%和4. 1天,P 0. 05。介入组患者的短期死亡率和致残率分别为0. 61%和2. 1%,均低于手术组的1. 27%和4. 7%,P 0. 05。介入组患者的1年期死亡率和致残率(2. 5%、2. 5%)均与手术组(2. 2%、1. 8%)无明显差异,P 0. 05。漏斗图未发现发表偏倚。敏感性分析结果一致。结论介入栓塞相比于手术夹闭可缩短患者的住院时间,降低患者的短期不良预后发生率。但是动脉瘤的闭塞率较低,1年期预后与手术夹闭无明显差异。据此推测手术夹闭患者的长期预后可能要好于介入栓塞,手术夹闭更适合于年轻患者。 相似文献
9.
Autoimmune comorbid diseases associated with lichen planus: a nationwide case–control study 下载免费PDF全文
10.