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排序方式: 共有181条查询结果,搜索用时 5 毫秒
1.
Janardhan J. Rao Vinaya EC. Kumar Sathavahana V. Chowdary Ram K. Babu Praveen Reddy Jitender Reddy 《Indian journal of otolaryngology and head and neck surgery》2005,57(1):30-34
Determination of obstructive site in obstructive sleep apnoea (OSA) is of paramount importance is planning the management. Cephalometric evaluation of lateral X-rays when combined with clinical assessment and fibreoptic examination of the airway helps in locating the site of obstruction. The usual technique of cephalometry has been modified so as to give a better delineation of the soft tissues. Holding a 2mm card board in the mouth and using barium paste helped in more accurate calculations. Using our technique, various parameters have been quantified and a number of controls were studied and normal range derived. Further improvement in cephalometry has been done by using C.T. cephlometry topogram technique. A topogram is a scan done on a running table top cranio-caudally. Using the topogram technique 38 OSA patients were evaluated for all the parameters. The technique, its advantages over traditional cephalometry and the values obtained in the study are discussed in this paper. 相似文献
2.
3.
S Frost Y Kanagasingam H Sohrabi J Vignarajan P Bourgeat O Salvado V Villemagne C C Rowe S Lance Macaulay C Szoeke K A Ellis D Ames C L Masters S Rainey-Smith R N Martins the AIBL Research Group 《Translational psychiatry》2013,3(2):e233
The earliest detectable change in Alzheimer''s disease (AD) is the buildup of amyloid plaque in the brain. Early detection of AD, prior to irreversible neurological damage, is important for the efficacy of current interventions as well as for the development of new treatments. Although PiB-PET imaging and CSF amyloid are the gold standards for early AD diagnosis, there are practical limitations for population screening. AD-related pathology occurs primarily in the brain, but some of the hallmarks of the disease have also been shown to occur in other tissues, including the retina, which is more accessible for imaging. Retinal vascular changes and degeneration have previously been reported in AD using optical coherence tomography and laser Doppler techniques. This report presents results from analysis of retinal photographs from AD and healthy control participants from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing. This is the first study to investigate retinal blood vessel changes with respect to amyloid plaque burden in the brain. We demonstrate relationships between retinal vascular parameters, neocortical brain amyloid plaque burden and AD. A number of RVPs were found to be different in AD. Two of these RVPs, venular branching asymmetry factor and arteriolar length-to-diameter ratio, were also higher in healthy individuals with high plaque burden (P=0.01 and P=0.02 respectively, after false discovery rate adjustment). Retinal photographic analysis shows potential as an adjunct for early detection of AD or monitoring of AD-progression or response to treatments. 相似文献
4.
Mishel Farasatpour Radhakrishna Janardhan Campbell D. Williams Julie A. Margenthaler Katherine S. Virgo Frank E. Johnson 《American journal of surgery》2013
Background
Schizophrenia has a powerful impact on the outcomes of treatment for physical disorders. This study sought to estimate how the presence of schizophrenia disrupts the course of diagnosis and initial treatment of breast cancer.Methods
We searched the Patient Treatment File, a comprehensive computer-based system for inpatient data in the Department of Veterans Affairs (DVA) medical system, to identify patients with codes for schizophrenia or schizoaffective disorder who later developed breast cancer. These data were augmented with chart-based clinical data.Results
There were 56 evaluable patients from 34 DVA facilities; 37 (66%) were female. Delay in diagnosis was common. The mean size of the primary tumor was 4 cm in those for whom these data were recorded. Delay in diagnosis was common and many never received the indicated surgery. Distant metastases were present on diagnosis in 12 (21%) and developed after diagnosis in 14 (25%) others, including 7 who inappropriately delayed or refused indicated surgery and 4 who inappropriately delayed or refused indicated neoadjuvant chemotherapy. Twelve verbally abused or physically attacked caregivers.Conclusions
Patients with schizophrenia who later develop breast cancer often deny they have cancer. They often have high-stage disease at diagnosis and often delay or refuse therapy. Breast-conserving multimodality therapy is often not feasible. 相似文献5.
B. R. Amar Ravi Yadav Y. C. Janardhan Reddy Pramod Kumar Pal 《Annals of Indian Academy of Neurology》2014,17(2):187-192
Aims:
The aim of the study was to study the clinical profile of the patients with Parkinson''s disease (PD) and psychosis.Settings and Design:
This was a prospective, cross sectional, hospital-based study done at the Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India from September 2009 to January 2011. All patients with PD, diagnosed by United Kingdom PD Society Brain Bank criteria, having with features of psychosis as diagnosed by the neuropsychiatric inventory (NPI) were included. Patients without a caregiver who could validate the patient''s symptoms were excluded.Results:
A total of 40 patients (5 women, 35 men) with PD with psychosis (mean age: 54.2 ± 11.5 years, mean duration of illness: 6.5 ± 4.5 years, and mean duration of psychosis: 4.3 ± 4.3 years) were included in the study. The Global NPI score was 19.1 ± 11.5. Majority of the patients had pure hallucinations (85%), while the rest had either pure delusions (7.5%) or a combination of delusions and hallucinations (7.5%). In those with hallucinations, visual hallucinations were the commonest (60%) (pure only in 22.5%), followed by auditory (45%), minor hallucinations (45%), and tactile (20%). Only one person reported having olfactory hallucinations (2.5%). Loss of insight was most often observed during the visual hallucinations (52%), followed by tactile (44.4%), auditory (38.9 %), and minor hallucinations (33.3%).Conclusions:
In patients with PD and psychosis, pure hallucinations are common and visual hallucinations are the commonest among the hallucinations. A large proportion of patients have minor hallucinations, which need to be recognized early for effective and early management. The limitations of the study were small sample size, use of a single scale to assess psychosis and subjective assessment of insight. 相似文献6.
A. M. Shenoy N. Grover N. Janardhan P NJayakumar T. Hegde S Satish 《Indian journal of otolaryngology and head and neck surgery》2002,54(4):274-279
This study is a retrospective analysis of 30 consecutive cases of Juvenile Nasopharyngeal Angiofibroma (JXA) operated at.
Department of Head and Neck Surgery, Kidwai Memorial Institute of Oncology Bangalore, India: la tertiary referral centre)
after prior emohilization by an interventional neuro-radiologisl (1996-2002). This study discusses critically the planning
of surgical approach, based on anatomico-radiological factors and highlights the efficacy of preoperalive embolization in
expediting total re moral of the tumor in 25 out of JO cases with advanced stage JNA.
Objectives: To analyze the utility of pre-operatire embolisation in surgical extirpation of large JNAs; planning of the surgical
approaches based on CT topography of the tumor; to study the various complications of embolisation and surgery associated
with JXA & lastly to evaluate the puttern and location of recurrent tumor thus correlating with the original topography.
Setting: Tertiary care cancer referral centre.
Patients: Patients ranged in age from ’)- 24 years. all being males.
Interventions: Majority of them were accessed by transfacial surgical approach(26). and in the recent past via midfacial degloving(4)
within 4H hours of angioembolisation.
Results: Complete removal of the tumor was achieved in 25 out of 30 cases with advanced stage JNA.
Post surgical CT scans revealed tumor residua in 5 individuals, where the tumor was documented in - the temporal fossa 12),
para-cavernous sinus region (I), cavernous sinus! I) and pterygo palatine fossa (I). Only the lesion in pterygopalaline fossa
was successfully re-i>xcised & this alongwith the recurrence at para-cavernous & cavernous sinus & another were treated with
radiotherapy; the 2 cases in the temporal fossa are under observation. The average blood loss during the procedure was 546.60
ml.
Conclusions: Today, advances in radiologie imaging-complemented by interventional neuro-radiological expertise in angio-embolisation
have expedited complète excision with minimal morbidity and acceptable recurrence rate. This study has justified pre-operative
embolisation and M currently the standard of care for advanced JXA. 相似文献
7.
Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance 总被引:5,自引:0,他引:5
Wierdl M Wall A Morton CL Sampath J Danks MK Schuetz JD Potter PM 《Molecular pharmacology》2003,64(2):279-288
The recently introduced camptothecin-derived chemotherapeutic agents have demonstrated remarkable promise in cancer therapy and as such have been approved for use in humans for the treatment of ovarian, lung, and colon cancer. CPT-11 is a prodrug that is activated by esterases to yield the potent topoisomerase I inhibitor, SN-38. Considerable success has been achieved in the treatment of both na?ve and drug-resistant colon cancer with CPT-11. However, mechanisms of resistance to this agent have not been explored in detail. The role of the ATP-dependent drug transporter ABCG2 in CPT-11 cytotoxicity is unclear because some ABCG2 mutants confer camptothecin resistance, whereas others do not. Because CPT-11 is activated by carboxylesterases (CEs), we assessed the relative contribution of each protein in mediating CPT-11 toxicity by both drug accumulation and cell growth-inhibition assays. Our results indicate that the expression of ABCG2 protects cells from CPT-11 toxicity, even in the presence of high levels of a rabbit liver carboxylesterase (rCE), which can efficiently activate the drug. However, this can be partially overcome by the ABCG2 inhibitor reserpine. These studies indicate that overexpression of ABCG2 in vivo would probably overcome any increased drug activation that might be achieved by gene delivery or antibody-directed enzyme prodrug therapy methods using rCE. 相似文献
8.
Jaisoorya TS Janardhan Reddy YC Srinath S 《European child & adolescent psychiatry》2003,12(6):290-297
Abstract.
Juvenile obsessivecompulsive disorder (OCD) has been
hypothesized to be different from adult-onset OCD suggesting
that juvenile OCD may be a developmental subtype of the
disorder. There is some evidence that juvenile OCD may be
phenotypically different from juvenile-onset adult OCD. This
study examines the phenotypic characteristics of juvenile OCD
(current age 18 years, n = 39), juvenile-onset adult OCD
(onset 18 years,cur rent age>18 years, n = 87) and
adult-onset OCD (onset > 18 years, n = 105). Qualified
psychiatrists expert in evaluating OCD subjects conducted
clinical and structured interviews. In the multinomial logistic
regression analysis, controlling for chronological age and
gender, the juvenile OCD was associated with male preponderance,
elev ated rates of certain obsessive-compulsive symptoms, a
ttention-deficit hyperactivity disorder, chronic tics, body
dysmorphic disorder and major depression. In addition,
juvenile-onset adult OCD differed from juvenile OCD by having
later age-atonset and low rate of ADHD. The juvenile-onset adult
OCD was positively associated with social phobia and chronic
tics compared to adult-onset OCD. The juvenile OCD appears to be
different from both juvenile-onset adult OCD and adult-onset OCD
supporting previous observations that juvenile OCD could be a
developmental subtype of the disorder. 相似文献
9.
Mydam Janardhan David Richard J. Rankin Kristin M. Collins James W. 《Maternal and child health journal》2019,23(4):538-546
Maternal and Child Health Journal - Objectives To explore associations between race, nativity, and low birth weight (LBW) among Latina and non-Latina women, with special attention to the Black... 相似文献
10.