全文获取类型
收费全文 | 2061篇 |
免费 | 96篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 148篇 |
妇产科学 | 15篇 |
基础医学 | 231篇 |
口腔科学 | 81篇 |
临床医学 | 106篇 |
内科学 | 330篇 |
皮肤病学 | 33篇 |
神经病学 | 133篇 |
特种医学 | 144篇 |
外科学 | 316篇 |
综合类 | 51篇 |
预防医学 | 113篇 |
眼科学 | 62篇 |
药学 | 187篇 |
中国医学 | 5篇 |
肿瘤学 | 171篇 |
出版年
2023年 | 15篇 |
2022年 | 30篇 |
2021年 | 69篇 |
2020年 | 30篇 |
2019年 | 48篇 |
2018年 | 54篇 |
2017年 | 37篇 |
2016年 | 44篇 |
2015年 | 41篇 |
2014年 | 73篇 |
2013年 | 87篇 |
2012年 | 148篇 |
2011年 | 175篇 |
2010年 | 82篇 |
2009年 | 73篇 |
2008年 | 135篇 |
2007年 | 120篇 |
2006年 | 111篇 |
2005年 | 87篇 |
2004年 | 79篇 |
2003年 | 72篇 |
2002年 | 68篇 |
2001年 | 53篇 |
2000年 | 40篇 |
1999年 | 48篇 |
1998年 | 16篇 |
1997年 | 19篇 |
1996年 | 7篇 |
1995年 | 8篇 |
1994年 | 7篇 |
1993年 | 7篇 |
1992年 | 20篇 |
1991年 | 22篇 |
1990年 | 20篇 |
1989年 | 12篇 |
1988年 | 12篇 |
1987年 | 21篇 |
1986年 | 16篇 |
1985年 | 16篇 |
1984年 | 16篇 |
1983年 | 10篇 |
1982年 | 11篇 |
1981年 | 8篇 |
1980年 | 7篇 |
1979年 | 12篇 |
1978年 | 14篇 |
1977年 | 4篇 |
1973年 | 4篇 |
1971年 | 6篇 |
1941年 | 4篇 |
排序方式: 共有2164条查询结果,搜索用时 15 毫秒
1.
N. S. Hari Narayana Moorthy Sergio F. Sousa Maria J. Ramos Pedro A. Fernandes 《Medicinal chemistry research》2016,25(7):1340-1357
Farnesyltransferase (FTase) is one of the prenyltransferase family enzymes that catalyse the transfer of 15-membered isoprenoid (farnesyl) moiety to the cysteine of CAAX motif-containing proteins including Rho and Ras family of G proteins. Inhibitors of FTase act as drugs for cancer, malaria, progeria and other diseases. In the present investigation, we have developed two structure-based pharmacophore models from protein–ligand complex (3E33 and 3E37) obtained from the protein data bank. Molecular dynamics (MD) simulations were performed on the complexes, and different conformers of the same complex were generated. These conformers were undergone protein–ligand interaction fingerprint (PLIF) analysis, and the fingerprint bits have been used for structure-based pharmacophore model development. The PLIF results showed that Lys164, Tyr166, TrpB106 and TyrB361 are the major interacting residues in both the complexes. The RMSD and RMSF analyses on the MD-simulated systems showed that the absence of FPP in the complex 3E37 has significant effect in the conformational changes of the ligands. During this conformational change, some interactions between the protein and the ligands are lost, but regained after some simulations (after 2 ns). The structure-based pharmacophore models showed that the hydrophobic and acceptor contours are predominantly present in the models. The pharmacophore models were validated using reference compounds, which significantly identified as HITs with smaller RMSD values. The developed structure-based pharmacophore models are significant, and the methodology used in this study is novel from the existing methods (the original X-ray crystallographic coordination of the ligands is used for the model building). In our study, along with the original coordination of the ligand, different conformers of the same complex (protein–ligand) are used. It concluded that the developed methodology is significant for the virtual screening of novel molecules on different targets. 相似文献
2.
N. K. Venkataramana V. R. S. Kolluri K. S. Narayana Swamy V. K. Jain B. S. Das S. Das 《Acta neurochirurgica》1990,107(1-2):44-46
Intradural extramedullary glial tumours of the spinal cord are rare. We report for such tumours arising from the dorsal cord. Myelography and operative findings were almost similar to that of an intradural neurofibroma. Surgical removal had resulted in rewarding neurological recovery. One of them had a recurrence after six years and was re-explored. Anterolateral attachment near the root entry zone suggests its origin probably from the spinal cord with an exophytic growth. 相似文献
3.
4.
5.
1.5 tesla magnetic resonance imaging of acute spinal trauma 总被引:2,自引:0,他引:2
Fifty patients with spinal injury above L2 were studied with MRI; forty-two had initial and followup studies permitting correlation of MRI abnormalities with neurologic improvement. Two discrete patterns of MRI abnormality were identified, presumably representing cord hemorrhage and edema respectively. A third pattern appeared to represent a mixed type of injury. The correlation between the MRI patterns of cord injury and neurologic recovery was excellent. The ability of MRI to demonstrate and characterize acute cord injury appears to exceed that of other diagnostic techniques. 相似文献
6.
G. K. Narayana 《Indian journal of otolaryngology and head and neck surgery》2003,55(2):136-136
Foreign body ear is a common problem. When it is impacted it can tax the resorces of each of us. An attempt is made in this paper to make a customable foreign body removal hook using a lumbar puncture needle. 相似文献
7.
8.
F. J. Taylor Varadaraj Shenoy C. P. Olinger J. F. Wasserman 《Medical & biological engineering & computing》1979,17(4):443-448
Intercranial aneurysm present an especially serious clinical problem, since their rupture generally results in death or permanent
brain damage. Recent work, conducted by the authors, indicated that this anomaly can be detected using spectral signature
analysis. A low-cost turnkey noninvasive aneurysm-detection system is being tested for this purpose. Using polarity-coincident
noise-added one-bit correlators, aneurysms have been successfully detected. 相似文献
9.
10.
A rare case of a segmental small intestinal (jejunal) lipomatosis is described. A 33-year-old male was admitted with a clinical diagnosis of an acute intestinal obstruction. A plain erect abdominal x-ray showed multiple air-fluid levels. On an exploratory laparotomy, a jejunojejunal intussusception was found secondary to a segmental submucosal lipomatosis. This was treated by a segmental resection and anastomosis, which resulted in a complete cure. Here we present this case with a review of the relevant literature. 相似文献