全文获取类型
收费全文 | 201321篇 |
免费 | 19452篇 |
国内免费 | 12179篇 |
专业分类
耳鼻咽喉 | 1742篇 |
儿科学 | 3286篇 |
妇产科学 | 1899篇 |
基础医学 | 18877篇 |
口腔科学 | 3672篇 |
临床医学 | 26922篇 |
内科学 | 24508篇 |
皮肤病学 | 2576篇 |
神经病学 | 7700篇 |
特种医学 | 7418篇 |
外国民族医学 | 59篇 |
外科学 | 15518篇 |
综合类 | 43005篇 |
现状与发展 | 54篇 |
一般理论 | 8篇 |
预防医学 | 19558篇 |
眼科学 | 4945篇 |
药学 | 23306篇 |
267篇 | |
中国医学 | 14752篇 |
肿瘤学 | 12880篇 |
出版年
2024年 | 790篇 |
2023年 | 2632篇 |
2022年 | 6750篇 |
2021年 | 8710篇 |
2020年 | 7186篇 |
2019年 | 5372篇 |
2018年 | 5524篇 |
2017年 | 6235篇 |
2016年 | 5574篇 |
2015年 | 9009篇 |
2014年 | 11450篇 |
2013年 | 12395篇 |
2012年 | 17754篇 |
2011年 | 18872篇 |
2010年 | 14330篇 |
2009年 | 12123篇 |
2008年 | 13586篇 |
2007年 | 13104篇 |
2006年 | 12080篇 |
2005年 | 10165篇 |
2004年 | 7530篇 |
2003年 | 7420篇 |
2002年 | 5754篇 |
2001年 | 4579篇 |
2000年 | 3554篇 |
1999年 | 2409篇 |
1998年 | 1303篇 |
1997年 | 1335篇 |
1996年 | 907篇 |
1995年 | 828篇 |
1994年 | 671篇 |
1993年 | 405篇 |
1992年 | 428篇 |
1991年 | 362篇 |
1990年 | 328篇 |
1989年 | 253篇 |
1988年 | 232篇 |
1987年 | 195篇 |
1986年 | 138篇 |
1985年 | 134篇 |
1984年 | 78篇 |
1983年 | 55篇 |
1982年 | 43篇 |
1981年 | 39篇 |
1980年 | 25篇 |
1979年 | 47篇 |
1978年 | 37篇 |
1976年 | 25篇 |
1973年 | 28篇 |
1970年 | 27篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Moderate sedatives have been increasingly used to improve patient comfort during flexible bronchoscopy (FB). However, routine use of moderate sedation during FB is controversial because its efficacy and safety are not well established.This study aims to evaluate the efficacy and safety of moderate sedation during FB.A search was made of Medline, EMBASE, and the Cochrane Library to May 2014.Randomized controlled trials (RCTs) and quasi-RCTs were included.The main analysis was designed to examine the efficacy of moderate sedation during FB in sedation than no-sedation.The willingness to repeat FB was significantly more in sedation than no-sedation (odds ratio [OR] 2.30; 95% confidence interval [CI] 1.11–4.73; P = 0.02; I2 = 22.5). The duration of FB was shorter in sedation group than no-sedation group (standardized mean difference [SMD] −0.21; 95% CI −0.38 to −0.03; P = 0.02; I2 = 78.3%). Event of hypoxia was not significantly different between sedation and no-sedation groups (OR 0.86; 95% CI 0.42–1.73; P = 0.67; I2 = 0%). The SpO2 during procedure was not different between sedation and no-sedation groups (SMD −0.14; 95% CI −0.37 to 0.08; P = 0.21; I2 = 49.9%). However, in subgroup analysis without supplemental oxygen, the SpO2 was significantly lower in sedation than no-sedation group (SMD −0.45; 95% CI −0.78 to −0.11; P = 0.01; I2 = 0.0%).According to this meta-analysis, moderate sedation in FB would be useful in patients who will require repeated bronchoscopies as well as safe in respiratory depression. To our knowledge, although the various sedative drugs are already used in the real field, this analysis was the first attempt to quantify objective results. We anticipate more definite and studies designed to elucidate standardized outcomes for moderate sedation in FB. 相似文献
2.
3.
4.
Xiujuan Tian Zhiying Chen Shaomin Shi Xianwen Wang Wanli Wang Ning Li Jing Wang 《Medicine》2015,94(37)
Oral cancer, predominantly oral squamous cell carcinoma (OSCC), is one of the most leading causes of cancers worldwide. Due to a low 5-year survival rate, highly effective methods for the early detection of OSCC are totally needed. MicroRNAs (miRNAs), as promising biomarkers, can bring insights into tumorigenesis of oral cancers. However, studies on the accuracy of miRNAs detection in OSCC have inconsistent conclusions, leading us to conduct this meta-analysis. The aim of this study was to systematically review the articles investigating the diagnostic value of miRNAs in OSCC.The PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), Web of Science were searched (updated to June 11th, 2015) to identify all articles evaluating the diagnostic yield of miRNAs for OSCC. The pooled sensitivity, specificity, and other diagnostic parameters were used to assess the performance of miRNAs assays on OSCC detection. Statistical analysis was conducted by employing the R software.The present meta-analysis comprised 23 studies from 10 articles, including 598 OSCC patients and 320 healthy individuals, available for analysis. The summary receiver operator characteristic (SROC) curve was plotted. Meanwhile, the pooled diagnostic parameters and the area under curve (AUC) were calculated based on all included studies. The pooled diagnostic parameters calculated from all 23 studies were as follows: pooled sensitivity of 0.759 (95% CI: 0.701–0.809), pooled specificity of 0.773 (95% CI: 0.713–0.823) and AUC of 0.832, which indicates a relatively high diagnostic accuracy of miRNAs in differentiating OSCC patients from healthy controls. Meanwhile, In addition, subgroup analyses were conducted to access the heterogeneity between studies, which is based on specimen (serum/plasma/blood/saliva/ tissue) and ethnicity (Asian/Caucasian).In summary, our meta-analysis suggests that miRNAs might be used in noninvasive screening tests for OSCC, which needs further large-scale studies to be validated. 相似文献
5.
A mixed‐method study of effects of a therapeutic play intervention for children on parental anxiety and parents' perceptions of the intervention 下载免费PDF全文
6.
7.
8.
9.
10.
目的:分析糖尿病视网膜病变合并黄斑水肿联合采用激光与复方血栓通胶囊治疗的临床疗效。方法:选取我院2017年1月—2019年1月收治的200例糖尿病视网膜病变合并黄斑水肿患者为研究对象,随机分为两组。对照组单独行激光治疗,观察组于对照组基础上联合复方血栓通胶囊治疗,对比两组临床疗效、治疗前后IL-6(白介素-6)、VEGF(血管内皮生长因子)、NOS(血清一氧化氮合成酶)水平变化情况。结果:对照组总有效率(68.00%,68/100)较观察组总有效率(98.00%,98/100)更高(P<0.05);与对照组对比,观察组治疗后NOS水平更高,IL-6、VEGF水平更低(P<0.05)。结论:糖尿病视网膜病变合并黄斑水肿联合采用激光与复方血栓通胶囊治疗的临床疗效显著,值得推广。 相似文献