乙醇硬化法治疗卵巢巧克力囊肿21例报告

本院对 2 1例卵巢巧克力囊肿施以无水乙醇硬化法治疗 ,获得较好的效果 ,现报告如下。1　临床资料一般资料 :临床确诊的卵巢巧克力囊肿患者 2 1。年龄2 8～ 35岁。囊肿最大直径为 4 0～ 110mm。单房 11例 ,多房 10例。 2 1例患者中有 16例有不同程度的痛经。全部患者均具有典型的巧克力囊肿超声图像改变 ,表现为囊肿边界欠清晰 ,囊壁厚 ,内壁欠光滑 ,囊肿内为透声较差的液性暗区 ,可见细小光点回声 ,有时囊肿与子宫密切粘连使囊肿声像图部分重叠。超声观察 2个月不见缩小或消失 ,且月经期囊肿体积有所增大。治疗方法 :选择月经干净后 3～ 5d…     

饥饿豚鼠应激性心律失常的观察

本文主要采用生物电测量的方法对饥饿豚鼠的应激能力进行了观察。实验结果显示饥饿豚鼠在实验条件下有异位起博和传导阻滞等明显心律失常的表现。     

禁食豚鼠应激能力观察

本文对不同禁食时间饥饿豚鼠的应激能力和心电活动进行了测量。结果显示：禁食早期（１２小时）豚鼠应激能力增加和体重增加，随着禁食时间延长机体应激能力下降和体重下降，并可出现明显的心律减缓。     

701跌打镇痛膏活血化瘀实验研究

<正>701跌打镇痛膏主要由土鳖虫、草乌、马钱子、大黄、水杨酸甲脂等14味药物组成,具有活血止痛,散瘀消肿,祛风胜湿的功效,临床上主要应用于急、慢性扭挫伤,慢性腰腿痛,风湿关节痛等病症,是中国外用贴膏类出口第一产品。虽然701跌打镇痛膏已经上市销售多年,在临床上也取得了一定的疗效,但是其活血化瘀作用目前尚未见相关实验报道。为进一步明确701跌打镇痛膏的活血化瘀作用,了解其作用特点而进行本研究。1材料与方法     

沙利度胺联合VAD方案治疗多发性骨髓瘤的疗效观察

目的探讨沙利度胺联合VAD方案治疗多发性骨髓瘤（MM）的临床疗效及不良反应。方法 47例多发性骨髓瘤患者随机分为VAD组（23例）：长春新碱＋阿霉素＋地塞米松;联合治疗组（24例）：沙利度胺＋VAD方案。结果联合治疗组总有效率为83.3%,明显优于对照组总有效率（60.9%,P〈0.05）;两组治疗后M蛋白、骨髓瘤细胞、β2-微球蛋白均明显下降（P〈0.05）,联合治疗组下降更为明显（P〈0.05）;两组患者血红蛋白明显上升（P〈0.05）,联合治疗组上升更为明显（P〈0.05）。副反应程度均可耐受。结论沙利度胺联合VAD方案治疗MM具有副作用少、耐受性好、给药方便、疗效明显的优点,值得临床推广应用。     

应激大鼠不同脑区Ca~（2＋）－ATPase和GSH－px活性的变化

利用捆扎大鼠四肢固定头部后淹水制成应激模型，观察大鼠在应激时不同脑区Ｃａ２＋－ＡＴＰａｓｅ和ＧＳＨ－ｐｘ活性的改变。结果显示Ｃａ２＋－ＡＴＰａｓｅ和ＧＳＨ－ｐｘ活性都有显著增加，Ｃａ２＋－ＡＴＰａｓｅ活性增加高峰的出现在丘脑、下丘脑（１ｈ）先于大脑皮层和海马（２ｈ），而ＧＳＨ－ｐｘ活性的增加，大脑皮层与海马较之丘脑、下丘脑更为显著和持久。提示，在应激状态下，清除自由基的能力和清除细胞内Ｃａ２＋的能力都有所增加。     

非血缘关系造血干细胞移植61例分析

Objective To study the therapeutic effectiveness, associated complications and related factors of unrelated allogeneic hematopoietic stem cell transplantation (URD-HSCT). Methods Sixty-one patients with malignant hematological diseases received URD-HSCT. All cases were subjected to myeloablative or nonmyeloablative conditioning regimen according to primary diseases. Among 61 patients, 21 were donor-recipient 6/6 HLA-matched, 5 were 5/6 HLA antigen-matched, 24 were 1 HLA gene subtype-mismatched, 11 were 2 HLA gene subtype-mismatched. Eighteen patients were ABO-compatible with donors, while 43 ABO-incompatible with donors. The median of infused donor nucleated cells was 4.5×108/kg, and the median of CD34+ cells were 4.3×106/kg. The graft-versus-host disease (GVHD) prevention regimens were based on short-term MTX, cyclosporin A and mycophenolate mofetil (MMF) regimen. Forty-nine cases also received CD25 Mab on the day of transplantation, and the day 4 after transplantation. Nine cases were also administrated with antilymphocyte globulin (ALG) or antithymocyte globulin (ATG). Two cases received ALG and CD25 Mab. Results Among 61 patients, 59 cases were successfully engrafted, which was identified by blood type, chromosome test and DNA polymorphism. Twenty-three cases developed grade Ⅱ～Ⅳ acute GVHD. Twenty-five patients experienced chronic GVHD. Infection of bacterial and/or fungal within 100 days after URD-HSCT was documented in 48 cases. Thirty-six cases had cytomegalovirus infection. Major infection site was lower respiratory tract. Eighteen cases died after URD-HSCT, and the 2-year disease-free survival rate was (68.0±6.4)%. Among these 18 deaths, 12 cases died because of transplantation related complications with the transplantation related mortality (TRM) being 19.7 %, and the remaining 6 cases died of relapse with the relapse rate being 9. 8 %, respectively. Conclusions URD-HSCT is an effective therapeutic strategy for malignant hematopoietic diseases when related donor is not available Acute GVHD and infection are risk factors of therapeutic effect and prognosis after URD-HSCT. Early prediction and prevention of acute GVHD and infection are essential problems to overcome.     

依替米星的耳毒性试验 Ⅲ.依替米星与庆大霉素、阿米卡星对前庭功能影响的比较

为比较依替米星与庆大霉素（ＧＭ）、阿米卡星（ＡＭＫ）长期给药对前庭功能的影响，本研究用豚鼠１３６只，分别用３种药物与生理盐水注射。每种药物又分４个剂量，每天肌注一次，共２８ｄ。给药期间，每周及给药完成后均检查一次前庭功能。结果表明：ＧＭ 随药物积累，前庭功能损伤极大，量效关系极显著。ＡＭＫ对前庭功能损伤较小。依替米星对前庭功能损伤更小。依替米星是一种前庭毒性不明显的新药。     

健康成人亮氨酸氨基肽酶参考值的调查

目的 了解并逐步建立本地区健康成人血清亮氨酸氨基肽酶(LAP)的参考值.方法 对体检健康者904例采用罗氏P800全自动生化分析仪测定血清LAP水平.结果 经统计学分析,各年龄组间LAP水平比较差异有统计学意义(P＜0.01),18～岁人群LAP检测结果最高为(43.67±8.17) U/L,而≥60岁人群最低为(35.75±7.41) U/L.男性LAP水平为(44.39±9.31) U/L,高于女性的(38.42±7.92)U/L,差异有统计学意义(P＜0.01);取中间分布的95％可信限((-x)±1.96s)作为参考范围计算结果为:成人男性血清LAP参考值为(26～63) U/L,成人女性参考值为( 23～54) U/L.结论 建议不同性别使用不同的正常参考值,男性(26～63) U/L,女性(23～54) U/L.