山东省肿瘤医院改扩建总体规划浅析

1 医院概况 山东省肿瘤医院是集医、教、研、防为一体,跨省区实施医疗服务的肿瘤防治研究中心,是全国肿瘤医院中较早评审认定的"三级甲等医院"、山东省一类科研院所、临床肿瘤学硕士、博士研究生带教点、国家药品临床研究基地和全省重点扶持发展的8个重点科研单位之一.     

Enhanced CD3~+/CD4~+ T Cell Activities and Modulation of Th1/Th2 Lineage Development in Irradiated Rats Due to Treatment with the Male Zooid of Antheraea Pernyi Extracts

Objective:Cancer patients undergoing large dose radiotherapy exhibit multifaceted defects in their immune capacity that are likely to contribute to an increased susceptibility to infections and disease progression.The immune impairment may also constitute a barrier to effective immunotherapeutic interventions.Here,we evaluate whether supplementation with the male zooid of Antheraea pernyi extracts could enhance immune function in irradiated rats.Methods:Fifty male Wistar rats were randomly divided into a...     

Enhanced CD3+/CD4+ T cell activities and modulation of Th1/Th2 lineage development in irradiated rats due to treatment with the male zooid of antheraea pernyi extracts

Objective  Cancer patients undergoing large dose radiotherapy exhibit multifaceted defects in their immune capacity that are likely to contribute to an increased susceptibility to infections and disease progression. The immune impairment may also constitute a barrier to effective immunotherapeutic interventions. Here, we evaluate whether supplementation with the male zooid of Antheraea pernyi extracts could enhance immune function in irradiated rats. Methods  Fifty male Wistar rats were randomly divided into a control group, a simple radiation group and a treatment group. The mice in the simple irradiation and treatment groups were given whole-chest irradiation with 6Gy. In the treatment group, the male zooid of Antheraea pernyi extracts was gavaged at the doses of 16.53mg/kg (large dose group), 2.62mg/kg (medium dose group), and 0.564mg/kg (small dose group) once a day for 14 days. The thymus and spleen indices were calculated. T cell subsets in peripheral blood were determined by flow cytometry and the expressions of IL-2, IFN-γ, IL-4 and IL-10 in sera were determined by ELISA on the 15th day. Results  The thymus index and spleen index of the high dose treatment group were statistically lower than that of the control group and higher than that of the radiation group (P<0.01). CD3+ and CD4+ T cells in the peripheral blood were increased in the high dose treatment group and decreased in the radiation group (P<0.01). Expression of IL-2 and INF-γ in the radiation group was lower than that in control, and significantly increased during therapy. The production of IL-4 and IL-10 could be induced by radiation and was inhibited in the high dose treatment group (P<0.01). Conclusion  Our data indicate that the male zooid of Antheraea pernyi extracts may be administrated to improve immune function in irradiated rats and reverse the radial immune inhibition of rats by stimulating the proliferation of Th cells and inducing the differentiation of Th2 to Th1. This work was supported by the grants from the National Natural Science foundation of China (No. 30472260), the Administration of Traditional Chinese Medicine of Shandong Province, China(No. 2005-109),, and the Health Protection Committee of Shandong Province, China(No. 2006059).     

我国癌症疼痛治疗现状

本文综述了我国1990年以来推广的癌症止痛工作,在癌痛治疗、研究等方面取得的进展。     

社会支持在青年乳腺癌化疗患者社交回避及苦恼与生育忧虑间的中介效应

目的探讨社会支持在青年乳腺癌化疗患者社交回避及苦恼与生育忧虑间的中介效应。方法本研究为横断面研究。采用便利抽样法, 选取2020年2月—2021年12月山东省肿瘤医院的180例青年乳腺癌化疗患者为研究对象。采用一般资料调查表、社会支持评定量表、癌症后生育忧虑量表(RCAC)、社交回避及苦恼量表(SADS)对患者进行调查。采用Pearson相关分析探讨青年乳腺癌化疗患者社会支持、社交回避及苦恼与生育忧虑的相关性。采用结构方程模型检验社会支持在社交回避及苦恼与生育忧虑间的中介效应。本研究共发放问卷180份, 回收有效问卷172份, 有效回收率为95.56%(172/180)。结果 172例青年乳腺癌化疗患者的SADS总分为(18.98±3.15)分, RCAC总分为(59.85±5.03)分, 社会支持评定量表总分为(33.53±4.25)分。Pearson相关分析结果显示, 社交回避及苦恼与生育忧虑呈正相关(r=0.810, P<0.01), 社会支持与生育忧虑、社交回避及苦恼呈负相关(r值分别为-0.570、-0.612;P均<0.01)。结构方程模型结果显示, 社会支持在...     

利用档案研究影响山东省肿瘤医院发展的主要因素

作者利用档案对山东省肿瘤医院30年来领导班子、职工的结构、学术成果及医院的发展等情况进行对比分析研究,认为院领导班子是决定医院发展的最重要因素.在前20年发展的基础上,目前医院已进入持续快速发展阶段.     

833例甲状腺癌临床流行病学统计分析

甲状腺癌是常见的恶性肿瘤之一,我院1971～1998年收入住院治疗的本省甲状腺癌患者共833例,现将有关资料进行统计分析。1　临床资料1.1　材料与方法本组资料均来自病人出院卡片和随访卡片,且全部资料经过计算机输入计算汇总,在Ｆｏｘｐｒｏｌ21下完成,资料可靠。1.2　结果1.2.1　性别和年龄　男性221例,女性612例,男女比1∶277。年龄9～89岁。20岁以下35例(42%),21～30岁157例(188%),31～40岁222例(267%),41～50岁175例(21%),51～60岁132例(158%),61～70岁95例(114%),70岁以上17例(2%)。1.2.2　地区分布　济南地区191例(2294%),居第1位。聊城…     

胃良、恶性病变中p16 蛋白表达的研究

 目的　探讨 p1 6蛋白在胃良、恶性病变中的表达及其与胃癌的发生、发展的关系。方法应用免疫组化 LSAB方法 ,对 1 0例正常胃粘膜、35例良性病变和 65例胃癌中 p1 6的表达进行了检测。结果　p1 6蛋白在正常胃粘膜中的阳性率为 1 0 0 % ,在良性病变中的阳性率自 75%至 87.5%不等 ,在胃癌中的阳性率为 30 .8%。在高、中分化胃癌中 p1 6的阳性表达率高于低、未分化者 (P<0 .0 5) ,p1 6的阳性表达与 TNM分期密切相关。结论　 p1 6参与了胃癌的发生、发展过程 ,对预后的判断有意义。     

30年持续发展与山东省肿瘤医院领导班子

山东省肿瘤医院经过30年的建设与发展，医、教、研、对外交流、业务建设均取得了辉煌的成就，利用档案对医院领导班子和职工的知识结构、年龄结构、专业结构、人才结构、对外交流、学术活动、医疗、科研、教学、制度、管理、大事记及医院的发展等情况进行分析研究发现，院领导班子是决定医院发展的最重要因素。