Prognostic Value of Two Polymorphisms,rs1045642 and rs1128503, in ABCB1 Following Taxane-based Chemotherapy: A Meta-Analysis

Objective: Genetic polymorphisms can influence the chemotherapeutic response; however, previous studies have produced conflicting results, and have failed to identify the most relevant polymorphisms for predicting the response to treatment in patients with cancer. The present meta-analysis was conducted to determine the correlation between two polymorphisms (rs1045642 and rs1128503) in ATP-binding cassette transporter B subfamily member 1 (ABCB1), which is associated with multidrug resistance, and the survival of patients treated with taxane-containing chemotherapy. Methods: Several databases, including PubMed and Embase, were used to retrieve articles evaluating the association between the ABCB1 rs1045642 and rs1128503 polymorphisms and survival, published prior to August 2019. The meta-analysis was conducted using R software to determine the pooled hazard ratio (HR) and 95% confidence intervals (95% CIs). Results: Fifteen studies involving 3320 patients were included in the meta-analysis. The effect of the rs1128503 polymorphism on progression-free survival remained significant in the heterozygote (HR 0.81; 95% CI: 0.67–0.98) and homozygote (HR 0.71; 95% CI: 0.58–0.88) models. The TT genotype rs1128503 was associated with better overall survival (HR 0.72; 95% CI: 0.53–0.97). Conclusion: Carriers of the rs1128503 T allele of ABCB1 showed a survival benefit after taxane-containing chemotherapy.     

短节段椎弓根钉内固定结合伤椎内植骨术治疗新鲜胸腰椎骨折

目的探讨短节段椎弓根钉内固定结合伤椎内植骨术治疗新鲜胸腰椎骨折的临床应用及疗效.方法采用后路短节段椎弓根钉系统复位固定并经伤椎椎弓根椎体内植骨术治疗新鲜胸腰椎骨折35例,分别于术前、术后及随访时测量伤椎前、后缘高度和 Cobb 角,比较植骨后推体高度的恢复度和 Cobb 角的纠正度.结果本组病例均获随访,平均随访时间12.5个月.平均骨折愈合时间5.4个月.全部随访患者未出现断钉、断棒及椎弓根钉拔出.所有病例术后及随访时椎体高度和 Cobb 角均纠正良好,脊柱椎体排列良好,椎体内植骨融合良好.其中11例1年后,10例1年半后取内固定物,取内固定物半年后拍片未见椎体高度丢失和塌陷.结论后路短节段椎弓根钉内固定结合伤椎内植骨术治疗新鲜胸腰椎骨折治疗能不仅有效恢复伤椎高度,尽早形成伤椎的骨性愈合,增加伤椎前、中柱的支撑力,重建了伤椎前、中柱的稳定性,而且保留伤椎邻近节段的运动单元功能,恢复脊柱的生理功能,有效防止断钉、内固定物松动、椎体前缘高度丢失、Cobb 角变大、继发腰椎不稳、临近节段间盘退变以及椎管狭窄等并发症的发生.     

不同亚型食管癌反流病患者胃组织白细胞介素-1β表达差异及临床意义

目的：对比研究典型症状与非典型症状的非糜烂反流病（NERD）患者胃组织白细胞介素-1β（IL-1β）的差异及临床意义。方法 N ERD 患者70例,按照有无典型反流症状,分为2个亚型：典型症状组43例、非典型症状组27例;采用化学发光法评估不同亚型N ERD患者胃组织中IL-1β的表达差异。结果与非典型症状组比较,典型症状组IL-1β水平明显降低,差异有统计学意义[（75．26±7．20） pg/mL vs ．（107．22±13．13） pg/mL ,P＝0．039]。结论典型症状和非典型症状的NERD患者胃组织IL-1β有明显差异,提示 IL-1β可能参与了不同亚型的NERD发生的机制。     

项针为主治疗椎-基底动脉供血不足52例临床观察

目的:观察项针为主结合头针治疗椎-基底动脉供血不足的疗效。方法:针刺治疗,取穴:大椎、风府、风池、翳明、后顶等穴。手法:用30号或32号1.0寸毫针常规针刺得气后,行提插、捻转或平补平泻手法,得气后留针30min。每日1次,治疗5次为1疗程,疗程间休息2d观察疗效。结果:52例中痊愈20例(38.5%),好转25例(48.1%),无效7例(13.5%),有效率86.5%。结论:项针为主结合头针治疗椎-基底动脉供血不足疗效确切。     

血管炎患者抗中性粒细胞胞浆抗体检测的意义

了解血管炎的发病机理、诊断和分类。方法采用间接免疫荧光法（ＩＦ）和酶联免疫吸附试验（ＥＬＩＳＡ）对５０例各类血管炎作血抗中性粒细胞胞浆抗体（ＡＮＣＡ）的定性及定量检测，同时应用ＰＥＧ－紫外分光定量法作循环免疫复合物（ＣＩＣ）水平测定。结果在结节性血管炎和变应性血管炎特别是前者的发病中，ＡＮＣＡ可能起较主要的作用，ＡＮＣＡ水平升高且定性呈阳性尤其是核周型ＡＮＣＡ阳性者，可能代表一组伴肾脏受累的血管炎患者。结论通过ＡＮＣＡ定性、定量及ＣＩＣ水平的检测，有助于血管炎的分类及诊断，并可用于判断器官受累的程度及评价治疗效果。