Human vulnerabilities,transgression and pleasure

In the face of the ‘obesity epidemic’ public health has largely failed to engage with the human pleasures that surround eating. Pleasures are often linked to vulnerabilities and frailties that are part of being human. We argue in this paper that leaving human vulnerabilities and the pleasures that haunt them under-acknowledged and under-examined within public health contributes to the problems that public health tries to solve. While in some quarters debates revolve around the best ways of encouraging people to become responsible for and modify their own behaviour, the well-documented centuries of struggle with managing human vulnerabilities and pleasures helps to explain why this is no easy task. The mantra of restraint, reason, and rationality is very limited in the face of the importance of some pleasures, even small ones, in human lives. In unequal societies, people have unequal access to pleasures. People are presented with a landscape of temptation, encouraged to consume, and then unequally admonished for indulging according to their means. Understanding and democratising pleasures will involve public health grappling with pleasures, and all those concerned with health inequity asking hard questions about ethics, morality, and intervention.     

Acetonitrile based single step slot-die compatible perovskite ink for flexible photovoltaics

The demonstration of photovoltaic devices with high power conversion efficiencies using low cost perovskite materials hints at the possibility of dramatically lowering the cost of solar energy. Key to further exploiting the potential of these materials is developing rapid processing techniques that can be used to deliver lower cost high throughput manufacture. This work details the development of low viscosity rapid drying perovskite formulations designed to give high quality solar films when slot-die coated on flexible roll-to-roll compatible substrates. A single step slot-die compatible perovskite ink based on an acetonitrile/methylamine solvent system utilizing a chloride additive is developed, resulting in large area perovskite films from slot-die coating under ambient conditions. The drying conditions for the perovskite film are optimized and fast (<10 min), low temperature (<120 °C) drying of slot-die coated films on flexible substrates are demonstrated and result in high performance devices.

Low viscosity rapid drying perovskite formulations designed to give high quality solar films when slot-die coated on flexible roll-to-roll compatible substrates are developed .     

The selenium status of children with phenylketonuria: results of selenium supplementation

The selenium status of children with phenylketonuria on a synthetic low phenylalanine diet was assessed. Correlation between blood selenium and red cell glutathione peroxidase was unsatisfactory (r = 0.65) due to the poor discrimination of red cell glutathione peroxidase with a low selenium diet. No symptoms of deficiency were observed. Supplementation with 50 micrograms per week of selenium as brewers yeast tablets over a period of 6 months significantly increased the blood selenium of the phenylketonuric children. Plasma Vitamin E levels were within normal limits. The supplementation effectively doubled their selenium intake to 15-17 micrograms per day, which is probably sufficient for this group with an adequate Vitamin E status, though considerably lower than the recommended minimum intake of 50 micrograms per day.     

The government and ethics of health promotion: the importance of Michel Foucault

A debate about the ethics of health promotion recently appearedin this journal. While the papers involved provided a numberof new insights into this area, they appeared to stop shortof many possibilities. In particular, the dismissal of the relevanceof the work of Foucault in this area prevented another lineof inquiry opening up. This paper provides a fuller explicationof Foucault's relevance of ethics and health promotion. It drawsattention to the way health promotion produces subjects, especiallychoosing subjects. Using nutrition promotion as an example,it highlights the way that various positions in health promotion—whichon the surface appear to be at odds with each other—canin fact be seen to be part of the same project: that of producingself-regulating subjects. The paper concludes by stressing thathealth promotion provides an ethics, in a Foucauldian sense,by producing the means by which subjects assess their own desires,attitudes and conducts in relation to those set out by healthpromotion expertise.     

The development of the gubernaculum and inguinal closure in the marsupial Macropus eugenii

This study reports the developmental anatomy of testicular descent and inguinal closure of the tammar wallaby (Macropus eugenii) from birth to maturity. In females the ovary migrated caudally between days 10 and 20 after birth. The gubernaculum differentiates into the round ligament in the abdomen and extra-abdominally as the ilio-marsupialis muscle of the mammary glands. In males the testes migrated to the internal inguinal ring by day 20 post partum (pp), coinciding with the enlargement of the gubernaculum, and from the internal inguinal ring to the scrotum between days 20 and 65 pp. During descent there was an increase in the hyaluronic acid concentration in cells of the gubernaculum and scrotum. Development of the cremaster muscle began by day 10 pp on the periphery of the gubernaculum and its basic structure was completed by day 60 pp. After descent the inguinal canal closed between days 50 and 60 pp, but a small irregular lumen persisted, somewhat similar to that seen in the congenital scrotal hydrocoele of humans. Tammars have a hopping mode of locomotion and, like humans, are essentially bipedal. We suggest that inguinal closure evolved in these two species because their upright posture may otherwise lead to a high incidence of inguinal hernias.     

A servo-mechanical bladder dynamic simulator

A method is described for the physical simulation of the dynamic behaviour of the urinary bladder. It has been found that the model can be controlled to an arbitrary pressure-volume characteristic essentially independent of the properties of the bladder material. Characteristic relationships between pressure and flow rate have also been observed in studies of the bladder, and this behaviour is also amenable to simulation.     

Synthesis, characterization and myocardial uptake of cationic bis(arene)technetium(I) complexes

A series of bis(arene)technetium(I) complexes has been synthesized from 99mTcO4- in order to study their organ distribution. Syntheses using either ultrasound/Al/AlCl3 or Zn/HCl gave products relatively free from transalkylation. The identity of the complexes was verified by comparison to the 99Tc complexes. Equivalence of the 99Tc and 99mTc complexes was demonstrated by HPLC techniques. Biodistribution studies in rats reveal substantial myocardial uptake for many members of the series, especially those containing benzene rings substituted with about four to six carbon atoms. The myocardial uptake is related to the lipophilicity of the complexes as measured by octanol/buffer partition ratios (OBPR). Optimal ranges of lipophilicity for maximal myocardial uptake occur for OBPR from 2 to 9. Rat and human plasma binding of the complexes increases with lipophilicity after a threshold value is exceeded.     

Use of Magnetic Resonance Imaging in Detection of Breast Cancer Recurrence: A Systematic Review

Background

Diagnosis of breast cancer recurrence can be difficult as a result of the presence of scar tissue in the breast. Magnetic resonance imaging (MRI) may be superior to traditional imaging in diagnosis of recurrence because of its ability to differentiate malignancy from scarring. Current guidelines on investigation of suspected breast cancer recurrence recommend MRI when other investigations have equivocal findings. We performed the first systematic review on this topic.

Methods

Literature search revealed 35 potentially relevant studies; 10 were included in final analysis. Included were clinical studies comparing MRI with another diagnostic modality for diagnosis of breast cancer recurrence, with at least 10 patients, in the English language. Data extraction focused on sensitivity and specificity of standard diagnostic modalities and MRI for diagnosis of local disease recurrence.

Results

In total 494 patients were assessed across 10 studies; all were case series. Sensitivity of MRI for detection of recurrence ranged 75?C100?%, while specificity ranged 66.6?C100?%. Both sensitivity and specificity increased when MRI was performed after a longer time interval from the original surgery, although the longest follow-up reported was only 36?months. A negative MRI can avoid the need for further biopsy.

Conclusions

Available data are based on clinically heterogeneous case series and superiority over standard triple assessment for breast cancer recurrence has not been proven. At present, MRI cannot be recommended in the routine diagnostic assessment for breast cancer recurrence but has a potentially useful role as a second-line investigation. A negative MRI is more useful than a positive MRI as positive MRIs require further investigation.