全文获取类型
收费全文 | 2099篇 |
免费 | 86篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 33篇 |
妇产科学 | 7篇 |
基础医学 | 265篇 |
口腔科学 | 49篇 |
临床医学 | 132篇 |
内科学 | 497篇 |
皮肤病学 | 30篇 |
神经病学 | 150篇 |
特种医学 | 92篇 |
外科学 | 534篇 |
综合类 | 8篇 |
预防医学 | 49篇 |
眼科学 | 27篇 |
药学 | 112篇 |
中国医学 | 13篇 |
肿瘤学 | 177篇 |
出版年
2023年 | 7篇 |
2022年 | 17篇 |
2021年 | 28篇 |
2020年 | 20篇 |
2019年 | 27篇 |
2018年 | 25篇 |
2017年 | 22篇 |
2016年 | 20篇 |
2015年 | 20篇 |
2014年 | 21篇 |
2013年 | 40篇 |
2012年 | 94篇 |
2011年 | 82篇 |
2010年 | 55篇 |
2009年 | 54篇 |
2008年 | 104篇 |
2007年 | 116篇 |
2006年 | 112篇 |
2005年 | 108篇 |
2004年 | 98篇 |
2003年 | 105篇 |
2002年 | 87篇 |
2001年 | 108篇 |
2000年 | 103篇 |
1999年 | 80篇 |
1998年 | 37篇 |
1997年 | 23篇 |
1996年 | 25篇 |
1995年 | 24篇 |
1994年 | 14篇 |
1993年 | 8篇 |
1992年 | 52篇 |
1991年 | 52篇 |
1990年 | 40篇 |
1989年 | 56篇 |
1988年 | 47篇 |
1987年 | 45篇 |
1986年 | 37篇 |
1985年 | 37篇 |
1984年 | 29篇 |
1983年 | 25篇 |
1982年 | 8篇 |
1979年 | 19篇 |
1978年 | 9篇 |
1974年 | 4篇 |
1973年 | 10篇 |
1972年 | 7篇 |
1971年 | 7篇 |
1970年 | 6篇 |
1967年 | 7篇 |
排序方式: 共有2197条查询结果,搜索用时 93 毫秒
1.
Acute tendon rupture of the extensor pollicis longus (EPL) is rare. We present acute EPL tendon rupture associated with avulsed fracture of the second metacarpal at the insertion of extensor carpi radialis longus. Tendon rupture of the EPL was repaired with end-to-end suture and avulsed fracture of the second metacarpal base was treated with open reduction and internal fixation. 相似文献
2.
3.
R Shiroki M Izumitani Y Tsukiashi S Saito K Ishiguro Y Fujioka I Nagakubo 《Hinyokika kiyo. Acta urologica Japonica》1990,36(11):1385-1388
Vasopressin, a hormone secreted from the posterior lobe of the hypophysis, has endocrinological and antidiuretic effects; it contracts vessels and smooth muscles, especially intestinal smooth muscle. In the present study, we investigated the role of vasopressin (Pitressin: arginine-vasopressin) in elimination of intestinal gas on excretory urography reading. Sixty outpatients were randomly divided into six groups. In Group I, the routine procedure was employed, i.e. laxatives the previous night and NPO the morning of the examination. In Groups II to VI, different dose regimens were employed: 6 or 10 units of Pitressin was administered by subcutaneous injection 30 minutes prior to injection of a contrast medium, with or without NPO. Intestinal gas elimination was evaluated by X-ray films taken before and after injection of Pitressin. The efficacy was rated by four grades. There were no significant differences in the gas elimination or occurrence of side effects between any two groups. Younger patients seemed to respond quickly to Pitressin and good effects were obtained. These results indicate that the pretreatment for excretory urography with 6 units of Pitressin without NPO may be a safe and effective alternative method for elimination of intestinal gas, in particular for young patients. 相似文献
4.
Pathogenesis of neuroimmunologic diseases 总被引:5,自引:0,他引:5
C. S. Constantinescu B. Milliard T. Fujioka M. K. Bhopale D. Calida Dr. A. M. Rostami 《Immunologic research》1998,17(1-2):217-227
Animal models of autoimmune diseases have greatly improved our current understanding of the pathogenesis of human autoimmunity
and have provided the potential for therapies based on manipulation of the immune system. In our laboratory, we have investigated
the immunopathogenesis of autoimmune diseases of the nervous system and muscle. We have developed immune-based approaches
for the suppression of experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), and experimental
autoimmune neuritis (EAN), a model for the Guillain-Barré syndrome (GBS). These approaches included induction of peripheral
tolerance, immunotoxin targeting of activated T cells, and cytokine manipulations. In addition, we identified the antigen
and characterized immunopathologically an autoimmune inflammatory disease of skeletal muscle, experimental autoimmune myositis
(EAM), a model for the human inflammatory muscle disease polymyositis. 相似文献
5.
M Nakamura E Koh N Kondoh M Takeyama M Namiki H Fujioka H Kiyohara Y Nishimune A Okuyama T Sonoda 《Archives of andrology》1990,24(1):69-72
The synthesis of DNA, RNA, and protein by varicocele testes with spermatogenic dysfunction was studied by examination of the levels of incorporation of [3H]thymidine, [14C]uridine, and [14C]leucine into the testicular tissue at 31 degrees C in vitro. The results suggest that DNA synthesis by the testis with moderate tubular damage is impaired whereas synthesis of RNA and protein is not. The cell regenerative ability of the testis with moderate tubular damage may be poor in spite of the preservation of testicular cell RNA and protein synthesis. 相似文献
6.
7.
A Tsuji M Takao T Asano T Fujioka H Nakamura K Mukai 《Hinyokika kiyo. Acta urologica Japonica》1987,33(5):738-742
A black adenoma of the adrenal cortex was surgically removed from an 18-year-old female who had clinical and laboratory findings characteristic of Cushing's syndrome. The electron microscopic study revealed typical features of steroid-producing cells, including a prominent smooth and rough endoplasmic reticulum, and mitochondria. In addition, many of the adenoma cells contained numerous pigmented granules which were lipofuscin. Three months after the surgery, the hormone levels returned to the normal range. The Japanese literature of functional black adenoma is reviewed. 相似文献
8.
Jong Il Kim Takeshi Tsujino Yoshio Fujioka Komei Saito Mitsuhiro Yokoyama 《Hypertension research》2003,26(4):307-313
We examined cellular membrane fatty acid composition and insulin sensitivity in patients with mild essential hypertension and hyperlipidemia, and investigated whether bezafibrate, a lipid-lowering drug, could improve elevated blood pressure and insulin sensitivity in these subjects by ameliorating cellular membrane fatty acid composition. Twenty-seven subjects were recruited. Twelve men with mild essential hypertension [systolic blood pressure (SBP) between 140 mmHg and 160 mmHg] and hypertriglyceridemia (plasma triglyceride concentration over 150 mg/dl) were designated the HL group. Fifteen men with mild essential hypertension and normotriglyceridemia (plasma triglyceride concentration below 150 mg/dl) were designated the NL group. Subjects in the HL group were given bezafibrate 400 mg/dl and those in the NL group were given placebo for 3 months. Bezafibrate significantly reduced SBP (140 +/- 2.6 to 131.8 +/- 2.6 mmHg, mean +/- SEM), diastolic blood pressure (DBP) (87.8 +/- 2.0 to 82.8 +/- 2.6 mmHg), fasting plasma triglyceride concentration (225.5 +/- 23.5 to 102.9 +/- 10.9 mg/dl), fasting plasma insulin concentration (9.6 +/- 0.8 to 7.1 +/- 0.8 microU/ml), and homeostasis model assessment scores (HOMA-R, 2.4 +/- 0.2 to 1.7 +/- 0.2), and significantly improved the insulin sensitivity index (56.0 +/- 3.0 to 70.7 +/- 4.8 mg x l2/mmol x mU x min) in the HL group. Regarding erythrocyte membrane fatty acid composition, bezafibrate reduced the percentages of saturated fatty acids (SFA) and increased the percentage of polyunsaturated fatty acids (PUFA). Plasma triglyceride concentrations were positively correlated with HOMA-R (r = 0.50, p < 0.01) and SFA (r = 0.39, p < 0.05), and negatively correlated with PUFA (r = -0.45, p < 0.05) before administration of placebo or bezafibrate. In conclusion, an improvement of hyperlipidemia by bezafibrate may be attributed to reduction of blood pressure and amelioration of insulin sensitivity. Abnormalities in membrane lipid composition may play an important role in these metabolic disorders. 相似文献
9.
10.
M. Fujioka M.D. K. Okuchi S. Miyamoto T. Sakaki S. Tsunoda S. Iwasaki 《Acta neurochirurgica》1994,131(3-4):265-269
Summary The authors describe a 66-year-old man with progressive gait disturbance caused by bilateral organized chronic subdural haematomas. The characteristics of these lesions on magnetic resonance (MR) images have not yet been clarified. The organized haematoma in our patient exhibited slight hypo-intensity on T 1-weighted MR images and marked hypo-intensity on T 2-weighted MR images obtained at 1.5 T. Preoperative MR imaging may give us useful information about surgical strategy in the case of chronic subdural haematoma with an unusual appearance on computed tomographic (CT) scans. 相似文献