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A. Kiss Á. Csontai M. Merksz P. Szónyi Gy. Gorácz 《International urology and nephrology》1996,28(6):787-792
A retrospective study was performed between 1985 and 1994 on paediatric patients operated for asymptomatic intrascrotal or
testicular palpable masses. Tumour was suspected in each case and it was surgically explored. Twenty-six children were affected,
their age ranging between 9 days and 14 years. In 11 cases testicular torsion, in 4 epididymitis and in another 2 dystrophic
calcification were found. Tumours, including rather rare alterations, were observed in only 9 children. The present results
draw attention to the tumour-like occurrence of testicular torsions and other benign alterations of the scrotum. 相似文献
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Gor DO Ding X Li Q Schreiber JR Dubinsky M Greenspan NS 《Infection and immunity》2002,70(10):5589-5595
Immunization of mice with pneumococcal surface adhesin A (PsaA) emulsified in complete Freund's adjuvant (CFA) provides protection against systemic infection with Streptococcus pneumoniae. Because the use of CFA is not acceptable in humans, we sought to develop alternative means of enhancing the immunogenicity of protein antigens of potential use in pneumococcal vaccines. We designed a series of genetic constructs in which coding sequences for PsaA were linked to sequences encoding either murine interleukin-2 (mIL-2), mIL-4, or two copies of an immunostimulatory nonapeptide derived from mIL-1beta. The PsaA-cytokine constructs were cloned and expressed in Escherichia coli. Mice immunized twice with PsaA-IL-2, or PsaA-IL-4 responded with PsaA-specific antibody production comparable in magnitude to that of mice primed with PsaA in CFA and boosted with PsaA in incomplete Freund's adjuvant (PsaA-Adj). Antibodies elicited by PsaA-Adj were predominantly of the immunoglobulin G1 (IgG1) subclass, while PsaA-IL-2 and PsaA-IL-4 elicited substantial amounts of IgG2a in addition to IgG1. Mice immunized with PsaA-Adj or PsaA-IL-4 were partially protected against intraperitoneal challenge with virulent S. pneumoniae (30% overall survival beyond 15 days postchallenge). Mice immunized with PsaA and no adjuvant or PsaA-IL-2 exhibited 0 or 5% survival rates, respectively, following challenge. In contrast, mice immunized twice with capsular polysaccharide were 100% protected. The modest levels of protection seen in mice immunized with PsaA and its more immunogenic derivatives may be explained in part by the relative inaccessibility of antibody to PsaA on the surface of encapsulated S. pneumoniae. 相似文献
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Mohammad Jalali Marzieh Mahmoodi Seyedeh Parisa Moosavian Ronak Jalali Gordon Ferns Abdolhamid Mosallanezhad Mohammad Hadi Imanieh Zahra Mosallanezhad 《Phytotherapy research : PTR》2020,34(8):1723-1733
The present systematic review and meta‐analysis was conducted to investigate the effects of ginger supplementation on markers of inflammatory and oxidative stress. PubMed, Embase, Scopus, and Web of Science were systematically searched to identify relevant clinical trials evaluating the effects of ginger on serum CRP (C‐reactive protein), TNF‐α (tumor necrosis factor‐alpha), IL‐6 (interleukin‐6), PGE2 (prostaglandin E2), TAC (total antioxidant capacity), and MDA (malondialdehyde) from inception up to September 2019. Mean difference and 95% confidence intervals were pooled using a random‐effects model. Potential publication bias was assessed using visual inspection of funnel plot and Egger's weighted regression tests. After excluding irrelevant records, 20 full‐text articles that included 25 separate studies were included to the meta‐analysis. Pooled results of this study indicated a statistically significant effect of ginger on serum CRP, TNF‐α, IL‐6, TAC, and MDA levels following ginger supplementation in compared to the controls. Also, the effects of ginger on serum PGE2 was marginally significant. Moreover, the high heterogeneity was disappeared in subgroup analysis performed by age, duration, dosage, and quality. This current analysis indicates that ginger supplementation has a significant effects on serum inflammatory and oxidative stress markers. 相似文献
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Case report and review of nonischemic spontaneous papillary muscle rupture reports between 2000 and 2015 下载免费PDF全文
Pishoy Gouda MB BCh BAO Lisa Weilovitch MD Ronak Kanani MD Bryan Har MD 《Echocardiography (Mount Kisco, N.Y.)》2017,34(5):786-790
Spontaneous papillary muscle rupture (PMR) is a rare cardiovascular emergency. We present a 63‐year‐old male who presents with acute dyspnea who was found to have an anterior PMR, with no evidence of coronary artery disease, infection, or trauma. A review of cases of nonischemic spontaneous PMR published in 2000–2015 identified 11 additional cases of spontaneous PMR. Posterior and anterior papillary muscles involvement was identified in 54.5% and 45.5% of cases, respectively. Rapid identification due to advances in imaging modalities and improved surgical management has led to optimal outcomes in patients with spontaneous PMR. 相似文献
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Wieneke Vlastra MD PhD Astrid C. van Nieuwkerk MD Anne-Sophie G.T. Bronzwaer PhD Adriaan Versteeg BSc Esther E. Bron PhD Wiro J. Niessen MD PhD Henk J.M.M. Mutsaerts MD PhD Björn J.P. van der Ster MSc Charles B.L.M. Majoie MD PhD Geert J. Biessels MD PhD Aart J. Nederveen MD PhD Mat J.A.P. Daemen MD PhD Matthias J.P. van Osch PhD Jan Baan MD PhD Jan J. Piek MD PhD Johannes J. Van Lieshout MD PhD Ronak Delewi MD PhD 《Journal of the American Geriatrics Society》2021,69(2):494-499
9.
Razavi Yasaman Keyhanfar Fariborz Haghparast Abbas Shabani Ronak Mehdizadeh Mehdi 《Metabolic brain disease》2021,36(6):1381-1390
Metabolic Brain Disease - Chronic methamphetamine (meth) abuse can lead to certain deficits in the hippocampal function by affecting the hippocampal neurogenesis and plasticity. To determine... 相似文献
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Kinsella Paul M. Smibert Olivia C. Whitlam John B. Steven Mark Masia Ricard Gandhi Ronak G. Kotton Camille N. Holmes Natasha E. 《European journal of clinical microbiology & infectious diseases》2021,40(12):2627-2631
European Journal of Clinical Microbiology & Infectious Diseases - Malakoplakia is a chronic granulomatous disease associated with incomplete clearance of bacterial pathogens. A multimodal... 相似文献