全文获取类型
收费全文 | 32718篇 |
免费 | 2678篇 |
国内免费 | 76篇 |
专业分类
耳鼻咽喉 | 551篇 |
儿科学 | 1311篇 |
妇产科学 | 1061篇 |
基础医学 | 4446篇 |
口腔科学 | 854篇 |
临床医学 | 2849篇 |
内科学 | 7655篇 |
皮肤病学 | 757篇 |
神经病学 | 3444篇 |
特种医学 | 1020篇 |
外国民族医学 | 3篇 |
外科学 | 4080篇 |
综合类 | 547篇 |
一般理论 | 45篇 |
预防医学 | 2415篇 |
眼科学 | 663篇 |
药学 | 1796篇 |
中国医学 | 8篇 |
肿瘤学 | 1967篇 |
出版年
2021年 | 475篇 |
2020年 | 298篇 |
2019年 | 506篇 |
2018年 | 557篇 |
2017年 | 393篇 |
2016年 | 455篇 |
2015年 | 516篇 |
2014年 | 700篇 |
2013年 | 1025篇 |
2012年 | 1361篇 |
2011年 | 1418篇 |
2010年 | 846篇 |
2009年 | 740篇 |
2008年 | 1290篇 |
2007年 | 1382篇 |
2006年 | 1370篇 |
2005年 | 1275篇 |
2004年 | 1282篇 |
2003年 | 1166篇 |
2002年 | 1226篇 |
2001年 | 1111篇 |
2000年 | 1173篇 |
1999年 | 988篇 |
1998年 | 369篇 |
1997年 | 310篇 |
1996年 | 322篇 |
1995年 | 300篇 |
1994年 | 294篇 |
1993年 | 305篇 |
1992年 | 869篇 |
1991年 | 810篇 |
1990年 | 697篇 |
1989年 | 736篇 |
1988年 | 681篇 |
1987年 | 710篇 |
1986年 | 658篇 |
1985年 | 684篇 |
1984年 | 543篇 |
1983年 | 470篇 |
1982年 | 306篇 |
1980年 | 264篇 |
1979年 | 462篇 |
1978年 | 313篇 |
1977年 | 259篇 |
1976年 | 284篇 |
1975年 | 270篇 |
1974年 | 306篇 |
1973年 | 299篇 |
1972年 | 268篇 |
1971年 | 262篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
Julia H. Vermylen Gordon J. Wood Elaine R. Cohen Jeffrey H. Barsuk William C. McGaghie Diane B. Wayne 《Journal of pain and symptom management》2019,57(3):682-687
Introduction
Physician communication impacts patient outcomes. However, communication skills, especially around difficult conversations, remain suboptimal, and there is no clear way to determine the validity of entrustment decisions. The aims of this study were to 1) describe the development of a simulation-based mastery learning (SBML) curriculum for breaking bad news (BBN) conversation skills and 2) set a defensible minimum passing standard (MPS) to ensure uniform skill acquisition among learners.Innovation
An SBML BBN curriculum was developed for fourth-year medical students. An assessment tool was created to evaluate the acquisition of skills involved in a BBN conversation. Pilot testing was completed to confirm improvement in skill acquisition and set the MPS.Outcomes
A BBN assessment tool containing a 15-item checklist and six scaled items was developed. Students' checklist performance improved significantly at post-test compared to baseline (mean 65.33%, SD = 12.09% vs mean 88.67%, SD = 9.45%, P < 0.001). Students were also significantly more likely to have at least a score of 4 (on a five-point scale) for the six scaled questions at post-test. The MPS was set at 80%, requiring a score of 12 items on the checklist and at least 4 of 5 for each scaled item. Using the MPS, 30% of students would require additional training after post-testing.Comments
We developed a SBML curriculum with a comprehensive assessment of BBN skills and a defensible competency standard. Future efforts will expand the mastery model to larger cohorts and assess the impact of rigorous education on patient care outcomes. 相似文献4.
We present the case of 7‐year‐old African American girl with loose anagen syndrome. Although this is a common cause of hair loss in Caucasian children, and there have been reports of cases occurring in dark‐skinned children of North African and Middle Eastern descent, to our knowledge there have been no cases reported in black children of sub‐Saharan African ancestry. We present this case to broaden the differential diagnosis of hair loss in African Americans. 相似文献
5.
6.
Greaney Mary L. Cohen Steven A. Blissmer Bryan J. Earp Jacob E. Xu Furong 《Quality of life research》2019,28(12):3249-3257
Quality of Life Research - Health-related quality of life (HRQoL) is an important indicator of population health, yet no age-specific trend analyses in HRQoL have been conducted with a nationally... 相似文献
7.
G. Shalom K. Kridin M. Babaev E. Magen S. Tiosano J. Dreiher A. Horev R. Khury D. Comaneshter N. Agmon-Levin A.D. Cohen 《The British journal of dermatology》2019,180(5):1077-1082
Osteoporosis is a condition in which the bones are thinner and more liable to fracture. It is commoner in women and in people over 50. It cannot be cured so the focus is on prevention, which means identifying and addressing risk factors such as obesity, low vitamin D, chronic inflammation and prolonged steroid medication. Chronic urticaria (hives, CU) is an inflammatory condition, so one might expect it to be linked with osteoporosis, but that has never been investigated. If people with CU are indeed more likely to develop osteoporosis, they could be advised about preventative measures. To study this, doctors from Israel identified 11,944 patients diagnosed with CU in a large medical database covering 4.5 million people. A potential difficulty was that people with CU are more likely to be female, obese and to have been treated with systemic steroids, all of which also increase the risk of osteoporosis. Therefore for each CU patient they studied 5 age- and sex-matched control patients (people of the same age and sex but without CU) and their analyses took into account other known risk factors for osteoporosis. During a 16 year period 8.7% of the patients with CU were diagnosed with osteoporosis compared with 6.8% of the controls. They concluded that CU is a small but significant additional risk factor for osteoporosis. An accompanying editorial cautions against basing conclusions on routine health records which may not have all the information required. Nonetheless, doctors treating chronic urticaria might bear in mind the risk of osteoporosis in their patients, and counsel accordingly. 相似文献
8.
9.
Role of intracortical mechanisms in the late part of the silent period to transcranial stimulation of the human motor cortex 总被引:3,自引:0,他引:3
J.P. Brasil-Neto A. Cammarota J. Valls-Solé A. Pascual-Leone M. Hallett L. G. Cohen 《Acta neurologica Scandinavica》1995,92(5):383-386
Transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (TES) of the human motor cortex produce a silent period (SP) following motor evoked potentials (MEPs). The early part of the SP can be explained by decreased alpha motor neuron excitability, whereas the late part is presumably due to suprasegmental mechanisms. In order to determine the level of the suprasegmental contribution to the generation of SPs, we recorded excitatory and inhibitory responses to TMS, TES, and percutaneous electrical brainstem stimulation (PBS) in the voluntarily activated first dorsal interosseous muscle of the hand. Stimulus intensities were set so that PBS and TES induced MEPs with areas equal to or larger than those of MEPs obtained with TMS. This procedure revealed that SPs were 49% and 83% shorter with TES and PBS, respectively, than with TMS. As TMS is more effective than TES or PBS in activating cortical interneurons, these findings support the idea that a significant component of the SP arises from intracortical mechanisms. 相似文献
10.
Rik C. Schoemaker Joop M. A. van Gerven Adam F. Cohen 《Journal of pharmacokinetics and pharmacodynamics》1998,26(5):581-593
The most widely applied model relating drug concentrations to effects is the Emax
model. In practice, concentration–effect relationships often deviate from a simple linear relationship but without reaching a clear maximum because a further increase in concentration might be associated with unacceptable or distorting side effects. The parameters for the Emax
model can only be estimated with reasonable precision if the curve shows sign of reaching a maximum, otherwise both EC50
and Emax
estimates may be extremely imprecise. This paper provides a solution by introducing a new parameter (S0
) equal to Emax/EC50
that can be used to characterize potency adequately even if there are no signs of a clear maximum. Simulations are presented to investigate the nature of the new parameter and published examples are used as illustration. 相似文献