全文获取类型
收费全文 | 28123篇 |
免费 | 1569篇 |
国内免费 | 68篇 |
专业分类
耳鼻咽喉 | 416篇 |
儿科学 | 1116篇 |
妇产科学 | 916篇 |
基础医学 | 4517篇 |
口腔科学 | 616篇 |
临床医学 | 2331篇 |
内科学 | 5630篇 |
皮肤病学 | 618篇 |
神经病学 | 2759篇 |
特种医学 | 1251篇 |
外国民族医学 | 14篇 |
外科学 | 4139篇 |
综合类 | 129篇 |
一般理论 | 3篇 |
预防医学 | 1444篇 |
眼科学 | 539篇 |
药学 | 1437篇 |
中国医学 | 22篇 |
肿瘤学 | 1863篇 |
出版年
2022年 | 225篇 |
2021年 | 464篇 |
2020年 | 286篇 |
2019年 | 394篇 |
2018年 | 497篇 |
2017年 | 406篇 |
2016年 | 559篇 |
2015年 | 543篇 |
2014年 | 713篇 |
2013年 | 924篇 |
2012年 | 1335篇 |
2011年 | 1410篇 |
2010年 | 725篇 |
2009年 | 749篇 |
2008年 | 1275篇 |
2007年 | 1346篇 |
2006年 | 1285篇 |
2005年 | 1319篇 |
2004年 | 1074篇 |
2003年 | 1045篇 |
2002年 | 973篇 |
2001年 | 920篇 |
2000年 | 936篇 |
1999年 | 807篇 |
1998年 | 351篇 |
1997年 | 276篇 |
1996年 | 228篇 |
1995年 | 209篇 |
1994年 | 187篇 |
1993年 | 182篇 |
1992年 | 482篇 |
1991年 | 510篇 |
1990年 | 494篇 |
1989年 | 408篇 |
1988年 | 390篇 |
1987年 | 405篇 |
1986年 | 403篇 |
1985年 | 393篇 |
1984年 | 275篇 |
1983年 | 223篇 |
1982年 | 139篇 |
1981年 | 147篇 |
1979年 | 265篇 |
1978年 | 187篇 |
1977年 | 156篇 |
1976年 | 155篇 |
1975年 | 169篇 |
1974年 | 195篇 |
1973年 | 172篇 |
1972年 | 159篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Mette Nissen Tiina‐Mari Ikheimo Jukka Huttunen Ville Leinonen Henna‐Kaisa Jyrkknen Mikael von und zu Fraunberg 《Neuromodulation》2021,24(1):102-111
ObjectiveSpinal cord stimulation (SCS) is an effective treatment in failed back surgery syndrome (FBSS). We studied the effect of preimplantation opioid use on SCS outcome and the effect of SCS on opioid use during a two-year follow-up period.Materials and methodsThe study cohort included 211 consecutive FBSS patients who underwent an SCS trial from January 1997 to March 2014. Participants were divided into groups, which were as follows: 1) SCS trial only (n = 47), 2) successful SCS (implanted and in use throughout the two-year follow-up period, n = 131), and 3) unsuccessful SCS (implanted but later explanted or revised due to inadequate pain relief, n = 29). Patients who underwent explantation for other reasons (n = 4) were excluded. Opioid purchase data from January 1995 to March 2016 were retrieved from national registries.ResultsHigher preimplantation opioid doses associated with unsuccessful SCS (ROC: AUC = 0.66, p = 0.009), with 35 morphine milligram equivalents (MME)/day as the optimal cutoff value. All opioids were discontinued in 23% of patients with successful SCS, but in none of the patients with unsuccessful SCS (p = 0.004). Strong opioids were discontinued in 39% of patients with successful SCS, but in none of the patients with unsuccessful SCS (p = 0.04). Mean opioid dose escalated from 18 ± 4 MME/day to 36 ± 6 MME/day with successful SCS and from 22 ± 8 MME/day to 82 ± 21 MME/day with unsuccessful SCS (p < 0.001).ConclusionsHigher preimplantation opioid doses were associated with SCS failure, suggesting the need for opioid tapering before implantation. With continuous SCS therapy and no explantation or revision due to inadequate pain relief, 39% of FBSS patients discontinued strong opioids, and 23% discontinued all opioids. This indicates that SCS should be considered before detrimental dose escalation. 相似文献
2.
Schneider Ralph Dettmer Marius Peters Nora Lamdark Tenzin Luedi Markus M. Adamina Michel Doll Dietrich 《European Surgery》2022,54(2):117-125
European Surgery - Treatment of pilonidal sinus disease (PSD) requires a tailored approach. A national guideline was published in 2014. The current status of surgical PSD therapy... 相似文献
3.
Hommes Franziska Mohsenpour Amir Kropff Dana Pilgram Lisa Matusall Svenja von Philipsborn Peter Sell Kerstin 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2022,65(1):96-106
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Akteure der öffentlichen Gesundheit (Public Health) tragen wesentlich zu Gesundheitsschutz, -förderung und... 相似文献
4.
5.
Erika Cecon Anna Ivanova Marine Luka Florence Gbahou Anne Friederich Jean‐Luc Guillaume Patrick Keller Klaus Knoch Raise Ahmad Philippe Delagrange Michele Solimena Ralf Jockers 《Journal of pineal research》2019,66(2)
Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression, and type 2 diabetes development. Melatonin receptors are approved drug targets for insomnia, non‐24‐hour sleep‐wake disorders, and major depressive disorders. In mammals, two melatonin receptors (MTRs) exist, MT1 and MT2, belonging to the G protein‐coupled receptor (GPCR) superfamily. Similar to most other GPCRs, reliable antibodies recognizing melatonin receptors proved to be difficult to obtain. Here, we describe the development of the first monoclonal antibodies (mABs) for mouse MT1 and MT2. Purified antibodies were extensively characterized for specific reactivity with mouse, rat, and human MT1 and MT2 by Western blot, immunoprecipitation, immunofluorescence, and proximity ligation assay. Several mABs were specific for either mouse MT1 or MT2. None of the mABs cross‐reacted with rat MTRs, and some were able to react with human MTRs. The specificity of the selected mABs was validated by immunofluorescence microscopy in three established locations (retina, suprachiasmatic nuclei, pituitary gland) for MTR expression in mice using MTR‐KO mice as control. MT2 expression was not detected in mouse insulinoma MIN6 cells or pancreatic beta‐cells. Collectively, we report the first monoclonal antibodies recognizing recombinant and native mouse melatonin receptors that will be valuable tools for future studies. 相似文献
6.
7.
Die Unfallchirurgie - Zur Diagnostik von Schultergelenkerkrankungen wird routinemäßig die Magnetresonanztomographie (MRT) durchgeführt. Diese kann entsprechend der klinischen... 相似文献
8.
9.
10.