全文获取类型
收费全文 | 20000篇 |
免费 | 1488篇 |
国内免费 | 82篇 |
专业分类
耳鼻咽喉 | 210篇 |
儿科学 | 715篇 |
妇产科学 | 346篇 |
基础医学 | 3219篇 |
口腔科学 | 509篇 |
临床医学 | 1583篇 |
内科学 | 4599篇 |
皮肤病学 | 463篇 |
神经病学 | 2361篇 |
特种医学 | 467篇 |
外科学 | 2230篇 |
综合类 | 83篇 |
一般理论 | 10篇 |
预防医学 | 1623篇 |
眼科学 | 227篇 |
药学 | 1365篇 |
中国医学 | 68篇 |
肿瘤学 | 1492篇 |
出版年
2023年 | 149篇 |
2022年 | 373篇 |
2021年 | 784篇 |
2020年 | 422篇 |
2019年 | 628篇 |
2018年 | 705篇 |
2017年 | 522篇 |
2016年 | 547篇 |
2015年 | 612篇 |
2014年 | 753篇 |
2013年 | 931篇 |
2012年 | 1471篇 |
2011年 | 1568篇 |
2010年 | 888篇 |
2009年 | 780篇 |
2008年 | 1209篇 |
2007年 | 1252篇 |
2006年 | 1143篇 |
2005年 | 1136篇 |
2004年 | 1074篇 |
2003年 | 961篇 |
2002年 | 865篇 |
2001年 | 346篇 |
2000年 | 343篇 |
1999年 | 318篇 |
1998年 | 174篇 |
1997年 | 157篇 |
1996年 | 125篇 |
1995年 | 103篇 |
1994年 | 75篇 |
1993年 | 70篇 |
1992年 | 156篇 |
1991年 | 114篇 |
1990年 | 111篇 |
1989年 | 77篇 |
1988年 | 63篇 |
1987年 | 51篇 |
1986年 | 55篇 |
1985年 | 58篇 |
1984年 | 46篇 |
1983年 | 35篇 |
1982年 | 28篇 |
1981年 | 22篇 |
1979年 | 29篇 |
1978年 | 28篇 |
1976年 | 24篇 |
1975年 | 24篇 |
1974年 | 17篇 |
1973年 | 23篇 |
1967年 | 15篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Ariel Paracampo Marina Solis Carlos Bonetto 《International journal of environmental health research》2015,25(1):96-103
Chlorpyrifos is the most used insecticide in Argentina. Cnesterodon decemmaculatus is a widely distributed, endemic fish from Neotropical America. It attains high densities in the shallow water assemblages of Argentina and Brazil. The aim of this study was to assess the acute toxicity of chlorpyrifos to C. decemmaculatus. The mean 96-h LC50 of three independent determinations was 105.3 (±?3.1) μg/L. Sublethal effects were observed. Swimming behavioral changes at each chlorpyrifos exposure concentration were reported. C. decemmaculatus represents a good model for ecotoxicological risk assessment. 相似文献
5.
Ana Lopez Alonso 《Platelets》2015,26(4):317-323
AbstractWhile the interactions between Gram-positive bacteria and platelets have been well characterized, there is a paucity of data on the interaction between other pathogens and platelets. However, thrombocytopenia is a common feature with many infections especially viral hemorrhagic fever. The little available data on these interactions indicate a similarity with bacteria-platelet interactions with receptors such as FcγRIIa and Toll-Like Receptors (TLR) playing key roles with many pathogens. This review summarizes the known interactions between platelets and pathogens such as viruses, fungi and parasites. 相似文献
6.
7.
Enrique Luengo Izaskun Buendia Cristina Fernndez‐Mendívil Paula Trigo‐Alonso Pilar Negredo Patrycja Michalska Borja Hernndez‐García Cristina Snchez‐Ramos Juan A. Bernal Tsuneya Ikezu Rafael Len Manuela G. Lpez 《Journal of pineal research》2019,67(1)
Alterations in autophagy are increasingly being recognized in the pathogenesis of proteinopathies like Alzheimer's disease (AD). This study was conducted to evaluate whether melatonin treatment could provide beneficial effects in an Alzheimer model related to tauopathy by improving the autophagic flux and, thereby, prevent cognitive decline. The injection of AAV‐hTauP301L viral vectors and treatment/injection with okadaic acid were used to achieve mouse and human ex vivo, and in vivo tau‐related models. Melatonin (10 μmol/L) impeded oxidative stress, tau hyperphosphorylation, and cell death by restoring autophagy flux in the ex vivo models. In the in vivo studies, intracerebroventricular injection of AAV‐hTauP301L increased oxidative stress, neuroinflammation, and tau hyperphosphorylation in the hippocampus 7 days after the injection, without inducing cognitive impairment; however, when animals were maintained for 28 days, cognitive decline was apparent. Interestingly, late melatonin treatment (10 mg/kg), starting once the alterations mentioned above were established (from day 7 to day 28), reduced oxidative stress, neuroinflammation, tau hyperphosphorylation, and caspase‐3 activation; these observations correlated with restoration of the autophagy flux and memory improvement. This study highlights the importance of autophagic dysregulation in tauopathy and how administration of pharmacological doses of melatonin, once tauopathy is initiated, can restore the autophagy flux, reduce proteinopathy, and prevent cognitive decline. We therefore propose exogenous melatonin supplementation or the development of melatonin derivatives to improve autophagy flux for the treatment of proteinopathies like AD. 相似文献
8.
9.
José Antonio Pereira Miguel Pera Manuel López-Cano Marta Pascual Sandra Alonso Silvia Salvans Marta Jiménez-Toscano Alba González-Martín Luis Grande-Posa 《Cirugía espa?ola》2019,97(1):20-26
Objectives
To determine the incidence of incisional hernia (IH) in the extraction incision (EI) in colorectal resection for cancer. To analyze whether the location of the incision has any relationship with the incidence of hernias and whether mesh could be useful for prevention in high-risk patients.Methods
Retrospective review of the colon and rectal surgery database from January 2015 to December 2016. Data were classified into 2 groups, transverse (TI) and midline incision (MI), and the latter was divided into 2 subgroups (mesh [MIM] and suture [MIS]). Patients were classified using the HERNIAscore. Hernias were diagnosed by clinical and/or CT examination.Results
A total of 182 out of 210 surgical patients were included. After a median follow-up of 13.0 months, 39 IH (21.9%) were detected, 23 of which (13.4%) were in the EI; their frequency was lower in the TI group (3.4%) and in the MIM group (5.9%) than in the MIS group (29.5%; p = 0.007). The probability of developing IH in the MIS group showed an OR = 11.7 (95%CI: 3.3-42.0) compared to the TI group and 4.3 (IC 95%: 1.1-16.3) versus the MIM group.Conclusions
The location of the incision is relevant to avoid incisional hernias. Transverse incisions should be used as the first option. When a midline incision is needed, a prophylactic mesh could be considered in high risk patients because it is safe and associated with low morbidity. 相似文献10.
Hagop Kantarjian Tapan Kadia Courtney DiNardo Naval Daver Gautam Borthakur Elias Jabbour Guillermo Garcia-Manero Marina Konopleva Farhad Ravandi 《Blood cancer journal》2021,11(2)
Progress in the understanding of the biology and therapy of acute myeloid leukemia (AML) is occurring rapidly. Since 2017, nine agents have been approved for various indications in AML. These included several targeted therapies like venetoclax, FLT3 inhibitors, IDH inhibitors, and others. The management of AML is complicated, highlighting the need for expertise in order to deliver optimal therapy and achieve optimal outcomes. The multiple subentities in AML require very different therapies. In this review, we summarize the important pathophysiologies driving AML, review current therapies in standard practice, and address present and future research directions.Subject terms: Prognosis, Health services 相似文献