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排序方式: 共有3128条查询结果,搜索用时 0 毫秒
1.
Israel Liberzon Stephan F Taylor K Luan Phan Jennifer C Britton Lorraine M Fig Joshua A Bueller Robert A Koeppe Jon-Kar Zubieta 《Neuropsychopharmacology》2007,61(9):1030-1038
BACKGROUND: Functional neuroimaging studies have detected abnormal limbic and paralimbic activation to emotional probes in posttraumatic stress disorder (PTSD), but few studies have examined neurochemical mechanisms that underlie functional alterations in regional cerebral blood flow. The mu-opioid neurotransmitter system, implicated in responses to stress and suppression of pain, is distributed in and is thought to regulate the function of brain regions that are implicated in affective processing. METHODS: Here we examined the micro-opioid system with positron emission tomography and the micro-opioid receptor-selective radiotracer [11C] carfentanil in 16 male patients with PTSD and two non-PTSD male control groups, with (n = 14) and without combat exposure (n = 15). Differences in micro-opioid receptor binding potential (BP2) were detected within discrete limbic and paralimbic regions. RESULTS: Relative to healthy controls, both trauma-exposed groups had lower micro-opioid receptor BP2 in extended amygdala, nucleus accumbens, and dorsal frontal and insular cortex but had higher BP2 in the orbitofrontal cortex. PTSD patients exhibited reduced BP2 in anterior cingulate cortex compared with both control groups. Micro-opioid receptor BP2 in combat-exposed subjects without PTSD was lower in the amygdala but higher in the orbitofrontal cortex compared with both PTSD patients and healthy controls. CONCLUSIONS: These findings differentiate the general response of the micro-opioid system to trauma from more specific changes associated with PTSD. 相似文献
2.
AIM: To determine the incidence of Type 2 diabetes and to examine the effect of different cut-points for impaired fasting glucose (IFG) on diabetes incidence. METHODS: Population-based longitudinal study (1990-2000) with clinical, anthropometric and biochemical measurements, including an oral glucose tolerance test (OGTT), in 1040 non-diabetic adults aged 40-69 years at baseline. Baseline glucose status was defined as normoglycaemia < 5.6, IFG-lower 5.6-6.0 and IFG-original 6.1-6.9 mmol/l. The all-IFG group included fasting glucose values of 5.6-6.9 mmol/l. RESULTS: The 10-year cumulative incidence of diabetes was 7.3 per 1000 person-years. Diabetes incidence was 2.4 [95% confidence interval (CI) 1.2, 4.8], 6.2 (4.0, 9.8) and 17.5 (12.5, 24.5) per 1000 person-years in those with normoglycaemia, IFG-lower and IFG-original, respectively. Compared with normoglycaemia, the age/sex-adjusted risk [hazard ratio (HR) and 95% CI] for incident diabetes was greatest in the IFG-original category (HR 6.9; 3.1, 15.2) and increased to a lesser degree in the IFG-lower (HR 2.5; 1.1, 5.7) and all-IFG categories (HR 4.1; 1.9, 8.7). When adjusted for confounding factors, the magnitude and direction of associations persisted, with HR 1.9, 4.4 and 2.9, for the categories IFG-lower, IFG-original and all-IFG, respectively. CONCLUSIONS: Diabetes incidence is more strongly related to IFG defined as fasting glucose between 6.1 and 6.9 mmol/l than to the lower category of 5.6-6.0 mmol/l, or entire range of 5.6-6.9 mmol/l. Future studies should examine the association of IFG with cardiovascular outcomes, but for diabetes risk our study supports the use of the IFG cut-point at 6.1 mmol/l. 相似文献
3.
Luan Shu Zi- Chun Hua 《中国药理通讯》2006,23(3):30-30
Triptolide is potent immunosuppressive has been reported to inhibit autoimmunity, compound isolated from Chinese herbal medicine. Triptolide allograft attributed to the suppression of T cells via NF - kB rejection and GVHD, and its efficacy was previously pathway and apoptosis. In the present study, we detailedly analyzed Triptolide' s function on murine primary T cell. We found that Triptolide could inhibit T cell activation and proliferation by dramatically down - regulating cell division and cell cycle. Triptolide inhibited T cell activation in a dose- dependent manner, and the inhibition was mediated by both NF- kB pathway and AP - 1 pathway. 相似文献
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应用声振仪对1992年2个月~1993年6个月单胎36~43周妊娠孕妇150例进行了声音振动刺激试验(VAS-T)并与无负荷试验(NST)对照。对此结果VAS-T(+)146例,(-)4例,NST反应型96例,无反应型54例。NST无反应型预测价值8%,假阴性率92%。NST无反应型经声音刺激后50例成VAS-T(+)。VAS-T预测价值99.3%。NST有效率66%,VAS-T有效率99%。NST至少需做20min,VAS-T95%在3min内达到标准,最长15min。为避免NST假无反应型,应进行VAS-T。 相似文献
6.
11例TH胶胃冠状静脉栓塞术临床治疗结果表明:(1)11例中的4例急性上消化道大出血患者均在12h左右出血基本停止,随访近一年未再发生出血现象。(2)10例半年后复查肝功能均有不同程度改善。(3)一年后复查食道钡餐透视X线平片发现8例患者食道静脉曲张有不同程度减轻。(4)11例中1例因术中急性肝功能衰竭死亡。因此我们认为此术式操作简便,手术创伤小、较易推广,是治疗门脉高压症合并食管胃底静脉曲张出血的一种有效方法。 相似文献
7.
在传统蒙成药的配制中需要很多名贵药材,而药源稀少,价格昂贵,供货紧张,以及实用代用品或以假乱真的现象极为普遍。这不仅影响临床效果,而严重伤害广大人民群众用药安全。所以试述三种蒙药药材鉴别的方法,该法简便易行,准确可靠,而不需特殊仪器设备,可快速鉴定,切合实用等。 相似文献
8.
目的 了解不同阶段重症监护病房(ICU)患者家属的需求状况。方法 选取符合入选标准的25名患者家属。分别在患者入CU24h内和72h后采用急危重患者家属需求量表(CCFN1)进行调查。结果 ICU患者家属72h后在接近患者需求、信息需求、情感及物质支持需求、舒适需求方面得分低于24h内的评分,且差异有显著性意义(P〈0.05,P〈0.01);而在保证患者安全方面的需求有升高趋势,但两者差异无显著性意义。结论患者入院初期,其家属处于极度应激状态,对各项需求都较高。72h后,随着应激水平的下降,其需求也相应有所降低,但保证患者安全的需求没有下降。提示医护人员要在患者八院初期,高度重视、满足家属的各种需求,以帮助其渡过急性应激期;同时要在整个治疗过程中时刻注意满足家属对患者安全和治疗的需求。 相似文献
9.
抗人甲状腺过氧化物酶抗体与其他自身抗体的关系 总被引:1,自引:1,他引:0
甲状腺过氧化物酶(TPO)是甲状腺微粒体的抗原成分。在纯化抗原建立测定抗TPO抗体ELISA法的基础上,并对抗TPO与其他自身抗体的伴随关系作了研究。发现除自身免疫性甲状腺病有较高阳性率外,SLE等患者抗TPO检出率也很高(10% ̄52.1%),且抗TPO阳性者,抗核抗体等其他自身抗体的阳性率也高达30.8% ̄95.2%。抗TPO抗体与其他自身抗体的相关系数r=0.7467(P〈0.01)。 相似文献
10.
Kermit Zhang Eleina Cox Samuel Strom Zhuo Luan Xu Alexis Disilvestro Kelly Usrey 《American journal of medical genetics. Part A》2020,182(9):2124-2128
Baraitser‐Winter cerebrofrontofacial syndrome (BWCFF) is a rare autosomal dominant developmental disorder associated with missense mutations in the genes ACTB or ACTG1. The classic presentation of BWCFF is discerned by the combination of unique craniofacial characteristics including ocular coloboma, intellectual disability, and hypertelorism. Congenital contractures and organ malformations are often present, including structural defects in the brain, heart, renal, and musculoskeletal system. However, there is limited documentation regarding its prenatal presentation that may encourage healthcare providers to be aware of this disorder when presented throughout pregnancy. Herein we describe a case of a pregnancy with large cystic hygroma and omphalocele. Whole exome sequencing (WES) was performed and a de novo, heterozygous, likely pathogenic mutation in ACTB was detected, c.1004G>A (p.Arg335His), conferring a diagnosis of BWCFF. 相似文献