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T. OKUYAMA S. HOKA M.D. H. OKAMOTO T. KAWASAKI K. YAMAURA S. TAKAHASHI 《Acta anaesthesiologica Scandinavica》1997,41(7):939-944
Background: Stimulation of myocardial α1 -adrenoceptors has been shown to exert positive inotropic effects through a cyclic AMP-independent mechanism. The purpose of this study was to examine if α1 -adrenoceptor stimulation is able to attenuate myocardial depression produced by exposure to halothane, and to test if α1 -adrenoceptor stimulation alters myocardial oxygen supply-demand balance in hearts exposed to halothane.
Methods: The effects of phenylephrine were examined in 7 isolated perfused rat hearts. Variables measured were: heart rate, isovolumetric peak left ventricular pressure (LVP), LV dP/dt, coronary arterial flow, myocardial O2 delivery (DO2 ), myocardial O2 consumption (MVO2 ) and the ratio of DO2 /MVO2 . Each heart was exposed to phenylephrine cumulatively 0.1 μM, 0.3 μM, 1 μM and 3 μM under the administration of 1% halothane in the presence of propranolol 1μM.
Results: Halothane 1% decreased the heart rate by 9±3%, LVP by 37±3%, and LV dP/dt by 35±2%. Phenylephrine restored these decreases to the baseline levels. Phenylephrine maintained or further enhanced the reductions in coronary flow and DO2 produced by halothane, resulting in a decrease in the DO2 / MVO2 ratio.
Conclusion: α1 adrenoceptor stimulation is capable of restoring direct cardiac depressant effects of halothane with a possible impairment of the oxygen supply-demand balance. 相似文献
Methods: The effects of phenylephrine were examined in 7 isolated perfused rat hearts. Variables measured were: heart rate, isovolumetric peak left ventricular pressure (LVP), LV dP/dt, coronary arterial flow, myocardial O
Results: Halothane 1% decreased the heart rate by 9±3%, LVP by 37±3%, and LV dP/dt by 35±2%. Phenylephrine restored these decreases to the baseline levels. Phenylephrine maintained or further enhanced the reductions in coronary flow and DO
Conclusion: α
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HOKA S.; KAWASAKI T.; OKAMOTO H.; OKUYAMA T.; TAKAHASHI S. 《British journal of anaesthesia》1995,74(4):438-442
We have investigated the effects of phenylephrine alone andcombined with prostaglandin E1 (PGE1) on ventriculo-arterialmatching during halothane anaesthesia in dogs. The ratio ofleft ventricular end-systolic elastance (Ees) to effective arterialelastance (Ea) was used as an index of ventriculo-arterial matching.In group 1 (n = 7), measurements were performed at control,1.5% halothane, halothane+phenylephrine 110 µgkg1 min1, and halothane + phenylephrine + PGE1,0.21.0 or 1.02.0 µg kg1 min1.In group 2 (n = 5), dobutamine 2 and 5 µg kg1 min1was infused during halothane anaesthesia. Halothane 1.5% decreasedmean arterial pressure (MAP), cardiac output and Ees. Phenylephrinerestored MAP, but further decreased cardiac output. The decreasein Ees produced by halothane was reversed by phenylephrine.PGE1 increased cardiac output and reversed the increases inEa and Ea/Ees during phenylephrine infusion. Dobutamine alsoreversed halothane-induced decreases in MAP, cardiac outputand Ees, and improved Ea/Ees. Our results indicate that combineduse of PGE1 with phenylephrine can eliminate the vasoconstrictiveproperty of phenylephrine, resulting in an improvement in ventriculo-arterialmatching. 相似文献
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