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Akman-Demir G Tüzün E Waters P Içöz S Kürtüncü M Jarius S Yapıcı Z Mutlu M Yeşilot N Vincent A Eraksoy M 《Journal of neurology》2011,258(3):464-470
Neuromyelitis optica (NMO) is an inflammatory/demyelinating disorder predominantly affecting the optic nerves and spinal cord.
Recent findings showed an underlying humoral abnormality in NMO, characterized by a serum antibody against aquaporin-4 (Aqp-4-Ab).
In this study, we evaluated the Aqp-4-Ab status among Turkish patients with NMO to determine the clinical and prognostic relevance.
Serum samples from 35 consecutive patients with NMO followed at a single center and diagnosed according to the 2006 revised
criteria, were evaluated for Aqp-4-Ab. All samples were obtained during a relapse prior to any immunosuppressive treatment.
Aqp-4-Ab was positive in 21/35 (60%) patients. Among these cases, 11 had an EDSS of 6.0 or more, whereas only two patients
in the seronegative group had such severe disability (p < 0.05). Overall, seropositive cases had a mean EDSS score of 5.1 ± 2.2 compared with 3.5 ± 1.7 in seronegative cases (p < 0.01). There were trends towards female predominance in seropositive cases and a monophasic course predominance in seronegative
cases. Disease duration, age at onset, number of attacks and time to definite NMO did not differ between groups. Our findings
in this single-center cohort suggest that the presence of Aqp-4-Ab might have a prognostic significance indicating a more
severe disease course. 相似文献
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