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Rafael Lucas Costa de Carvalho Miguel Lia Tedde Jose Ribas Milanese de Campos Niura Noro Hamilton Gustavo Falavigna Guilherme Vanessa Moreira Sousa Vitor Floriano Salomao Junior Flavio Henrique Savazzi Paulo Manuel Pego-Fernandes 《Journal of pediatric surgery》2021,56(3):545-549
Background/PurposeThe aim of the study was to evaluate the postoperative quality of life (QoL) of patients who underwent minimally invasive repair of pectus excavatum (MIRPE) with a newly designed bar and bar stabilizers.MethodsWe conducted a prospective randomized study in which patients were operated either with standard perpendicular stabilizers (control group) or with the newly designed oblique stabilizers (intervention group). All patients were evaluated 6 months after the operation with the Pectus Excavatum Evaluation Questionnaire (PEEQ).ResultsThere were 16 patients in the control group and 14 in the intervention group. Mean age was 17 (SD: 3.3, range 14–27) years. There were no demographic differences between groups. Two patients in the control group and one in the intervention group were repaired with two bars instead of one. There was one reoperation in each group. There was a significant difference between the pre- and postoperative scores, in both groups, in the patient body image domain (control group: 9.5 to 3; p < 0.01; intervention group 10 to 3; p < 0.01), as well as in the psychosocial domain (control group: 13.5 to 24, p < 0.01; intervention group: 15 to 24, p < 0.01). With regards to the patients' perception of physical difficulties before and after MIRPE, the difference between pre- and postoperative scores was greater in the intervention group (8 to 12, p < 0.01) than in the control group (10 to 11, p = 0.04). The mean length of stay was 4.5 and 5 days in the intervention group and the control group, respectively.ConclusionOur study showed that patients who underwent MIRPE with the newly designed bars and stabilizers had non-inferior outcomes than patients reported in the literature who underwent MIRPE with standard bars and stabilizers. We found slightly better outcomes in patients in the intervention group compared to the control group, but larger studies will be needed to confirm if those differences are statistically significant.Level of evidenceII 相似文献
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K V Shepard J Faintuch J D Bitran D L Sweet E Robin B Levin 《Cancer treatment reports》1985,69(1):123-124
Twenty patients with measurable metastatic colorectal carcinoma were treated every 3 weeks with cisplatin (100 mg/m2 iv) on Day 1 and 5-FU (1000 mg/m2/day by iv infusion over 24 hours) on Days 1-5. Seven patients were previously treated with chemotherapy. The mean performance status for all of the patients was 1.5 (Eastern Cooperative Oncology Group). None of the patients had an objective response to the chemotherapy; 11 patients had stable disease and nine had no response. This study demonstrates that the combination of cisplatin and 5-FU, administered at this dose and schedule, has minimal activity in patients with metastatic colorectal cancer. 相似文献
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Karla V. G. Lima Raquel P. A. Lima Maria C. R. Gonçalves Joel Faintuch Liana C. S. L. Morais Luiza S. R. Asciutti Maria J. C. Costa 《Obesity surgery》2014,24(5):771-776
Background
To our knowledge, the frequency of serum chromium deficiency in patients awaiting bariatric surgery has not been determined. This study was designed to assess chromium concentration and its association with glycemic levels and lipid profile in patients prior to bariatric surgery.Methods
This study recruited 73 candidates for bariatric surgery between March and September 2012. Their sociodemographic, anthropometric, and biochemical data were collected.Results
Of the 73 patients, 55 (75.3 %) were women (75.34 %). Mean patient age was 37.20?±?9.92 years, and mean body mass index was 47.48 kg/m2 (range, 43.59 to 52.50 kg/m2). Chromium deficiency was observed in 64 patients (87.7 %). Correlation analysis showed significant negative relationships between chromium concentration and BMI and zinc concentration and a significant positive relationship between chromium and glycated hemoglobin. Multiple linear regression analysis showed that serum chromium concentration was significantly associated with total cholesterol (β?=?0.171, p?=?0.048) and triglyceride (β?=??0.181, p?=?0.039) concentrations.Conclusions
Serum chromium deficiency is frequent in candidates for bariatric surgery and is associated with total cholesterol and triglyceride concentrations. Early nutritional interventions are needed to reduce nutritional deficiencies and improve the lipid profile of these patients. 相似文献9.
S.C. Silva G.L. Baggio-Zappia M.K.C. Brunialti M.S.C. Assun?ao L.C.P. Azevedo F.R. Machado R. Salomao 《Brazilian journal of medical and biological research》2014,47(5):384-393
Recognition of pathogens is performed by specific receptors in cells of the innate
immune system, which may undergo modulation during the continuum of clinical
manifestations of sepsis. Monocytes and neutrophils play a key role in host defense
by sensing and destroying microorganisms. This study aimed to evaluate the expression
of CD14 receptors on monocytes; CD66b and CXCR2 receptors on neutrophils; and TLR2,
TLR4, TLR5, TLR9, and CD11b receptors on both cell types of septic patients.
Seventy-seven septic patients (SP) and 40 healthy volunteers (HV) were included in
the study, and blood samples were collected on day zero (D0) and after 7 days of
therapy (D7). Evaluation of the cellular receptors was carried out by flow cytometry.
Expression of CD14 on monocytes and of CD11b and CXCR2 on neutrophils from SP was
lower than that from HV. Conversely, expression of TLR5 on monocytes and neutrophils
was higher in SP compared with HV. Expression of TLR2 on the surface of neutrophils
and that of TLR5 on monocytes and neutrophils of SP was lower at D7 than at D0. In
addition, SP who survived showed reduced expression of TLR2 and TLR4 on the surface
of neutrophils at D7 compared to D0. Expression of CXCR2 for surviving patients was
higher at follow-up compared to baseline. We conclude that expression of recognition
and cell signaling receptors is differentially regulated between SP and HV depending
on the receptor being evaluated. 相似文献
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Two patients with inflammatory bowel disease and no history of bilio-pancreatic disorders or alcoholism developed acute pancreatitis after therapy with sulfasalazine. The treatment lasted two months in the first case and four days in the second. The onset of pancreatic complications was heralded by jaundice; abdominal pain was a late symptom. The clinical course was dramatic in both cases, and one patient died. These findings agree with the hypothesis that sulfasalazine like other sulfonamidic compounds is a potentially pancreotoxic drug. 相似文献